MCM4 and SSRP1

Number of citations of the paper that reports this interaction (PubMedID 16902406)
38

Data Source:
HPRD (in vivo)

		MCM4	SSRP1
Description		minichromosome maintenance complex component 4	structure specific recognition protein 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Membrane MCM Complex CMG Complex	Nucleus Nucleoplasm Chromosome Nucleolus FACT Complex
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity	DNA Binding Chromatin Binding RNA Binding Protein Binding Nucleosome Binding Histone Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Regulation Of DNA-templated DNA Replication Initiation Mitotic DNA Replication Initiation	DNA Replication DNA Repair Nucleosome Assembly Nucleosome Disassembly DNA Damage Response Regulation Of Chromatin Organization
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Eosinophil percentage of white cells ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252) Reticulocyte count ( 32888494)
Interacting Genes		28 interacting genes: CCNA1 CDC5L CDC7 CDK1 CDK2 CDT1 CEBPA DBF4 EP300 ESCO2 LIG4 MCM2 MCM3 MCM6 MCM7 MCM8 MCMBP ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 SSRP1 SUMO2 SUPT16H TLX2 UBE3A	19 interacting genes: AURKA CEBPA CHD1 CHMP1B CSNK2A1 DHX9 EXOSC10 H3-3A MCM4 MYCBP NEK9 PTEN RAN ROBO2 SPI1 SREK1 SRF SUMO2 UBE2I
Entrez ID		4173	6749
HPRD ID		09094	05061
Ensembl ID		ENSG00000104738	ENSG00000149136
Uniprot IDs		B3KMX0 B4DLA6 P33991	Q08945
PDB IDs		6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ	4IFS 5UMR 5UMS 5VWE 6L1E 6L1R 6L34 6UPK 6UPL 9EH2
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Metabolic Process DNA Replication Initiation Nuclear Origin Of Replication Recognition Complex Regulation Of DNA Replication Nucleic Acid Metabolic Process Origin Recognition Complex Chromosome, Telomeric Region Nucleobase-containing Compound Metabolic Process MCM Complex Nucleoplasm Regulation Of DNA-templated DNA Replication Initiation DNA Replication Origin Binding DNA Repair Nucleus Macromolecule Metabolic Process DNA Damage Response Regulation Of DNA Metabolic Process Double-strand Break Repair Via Break-induced Replication Chromosome CMG Complex Double-strand Break Repair Cellular Response To Stress Positive Regulation Of DNA Replication Positive Regulation Of DNA-templated DNA Replication DNA Binding Single-stranded DNA Helicase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination DNA Recombination Recombinational Repair G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Chromatin Binding ATP Binding Single-stranded DNA Binding Regulation Of Nuclear Cell Cycle DNA Replication DNA-templated DNA Replication Helicase Activity Cyclin A1-CDK1 Complex Cyclin A1-CDK2 Complex Regulation Of Primary Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Division Nucleotide Binding Mitotic DNA Replication Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex	Nucleoplasm Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleus Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Proteolysis Nucleotide Binding Importin-alpha Family Protein Binding Membrane Assembly Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process STAT Family Protein Binding Positive Regulation Of Protein Catabolic Process Spindle Assembly Involved In Female Meiosis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Nuclear Pore Chromatin DNA Binding Meiotic Spindle Assembly Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process Interleukin-6-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cell Development Membraneless Organelle Assembly SUMO Transferase Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Meiotic Spindle Organization Positive Regulation Of Catabolic Process Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Nuclear Membrane Reassembly Histone Deacetylase Binding Positive Regulation Of RNA Metabolic Process Osteoblast Differentiation Presynaptic Cytosol Granulocyte Differentiation Protein Heterodimerization Activity ATP Binding Mitotic Cell Cycle Postsynaptic Cytosol Regulation Of Axonogenesis Viral Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process
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