MCM4 and TLX2

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		MCM4	TLX2
Gene Name		minichromosome maintenance complex component 4	T-cell leukemia homeobox 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Membrane MCM Complex	Cellular_component Nucleus Cytoplasm
	Molecular Function	Single-stranded DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding	Molecular_function Sequence-specific DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication	Mesoderm Formation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Biological_process Enteric Nervous System Development Negative Regulation Of Dendrite Morphogenesis
Pathways		Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: CCNA1 CDC5L CDC7 CDK1 CDK2 CDT1 DBF4 LIG4 MCM2 MCM3 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 RPA1 RPA2 SSRP1 SUPT16H TLX2	9 interactors: GTF2A1L IRF6 IRF9 MCM4 MEIS1 POU2F1 TLE1 YWHAH ZNF502
Entrez ID		4173	3196
HPRD ID		09094	07254
Ensembl ID		ENSG00000104738	ENSG00000115297
Uniprot IDs		B3KMX0 B4DLA6 P33991	F1T0F2 O43763
PDB IDs			3A03
Enriched GO Terms of Interacting Partners?		DNA Replication G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Metabolic Process DNA-dependent DNA Replication Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Cell Cycle DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus DNA Repair Chromosome Organization Cellular Response To Stress Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Metabolic Process DNA Unwinding Involved In DNA Replication Double-strand Break Repair Nucleotide-excision Repair, DNA Gap Filling DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition DNA Recombination DNA Conformation Change Regulation Of Cell Cycle Process Regulation Of DNA Replication DNA Recombinase Assembly Organelle Organization DNA Damage Checkpoint Regulation Of DNA-dependent DNA Replication Initiation Regulation Of Cell Cycle Metabolic Process Response To Stress Positive Regulation Of DNA Replication Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Mitotic Cell Cycle	Cellular Macromolecule Biosynthetic Process Transcription, DNA-templated Macromolecule Biosynthetic Process RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Lens Morphogenesis In Camera-type Eye Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Glucocorticoid Catabolic Process Lens Development In Camera-type Eye Regulation Of Metabolic Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Positive Regulation Of Transcription, DNA-templated Interferon-gamma-mediated Signaling Pathway Camera-type Eye Morphogenesis Cellular Response To Interferon-gamma Positive Regulation Of Macromolecule Biosynthetic Process Eye Morphogenesis Response To Interferon-gamma Positive Regulation Of Cellular Biosynthetic Process Olfactory Placode Formation Negative Regulation Of Neuron Differentiation Organ Development Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Dendrite Morphogenesis Lens Induction In Camera-type Eye Type I Interferon Biosynthetic Process DNA Unwinding Involved In DNA Replication Positive Regulation Of Metabolic Process Negative Regulation Of Neurogenesis Organ Morphogenesis Keratinocyte Proliferation Negative Regulation Of Anoikis Type I Interferon Production Negative Regulation Of Dendrite Development
Tagcloud ?		adh8l alveolus bmp16 clu1 clu2 coho col1a1 col1a2 cyp19a1a dcn ddit4l droplet fishes fn1 fsh fshr inha ivns1abpa maturing oogenesis perinucleolus pim1 salmon smad5l steroidogenesis suite vitellogenic wapl wt2l	atoh1 atoh1a atoh1and conditional coregulate crest determinant ear elusive eya2 fate fgf fgfr fgfs ganglia hair ontogeny otic postfertilization sag segmentation seq sox9 sox9a specify statoacoustic ultricular uncovered zebrafish
Tagcloud (Difference) ?		adh8l alveolus bmp16 clu1 clu2 coho col1a1 col1a2 cyp19a1a dcn ddit4l droplet fishes fn1 fsh fshr inha ivns1abpa maturing oogenesis perinucleolus pim1 salmon smad5l steroidogenesis suite vitellogenic wapl wt2l	atoh1 atoh1a atoh1and conditional coregulate crest determinant ear elusive eya2 fate fgf fgfr fgfs ganglia hair ontogeny otic postfertilization sag segmentation seq sox9 sox9a specify statoacoustic ultricular uncovered zebrafish
Tagcloud (Intersection) ?