MCM4 and ORC2

Number of citations of the paper that reports this interaction (PubMedID 12614612)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vitro)

		MCM4	ORC2
Description		minichromosome maintenance complex component 4	origin recognition complex subunit 2
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Membrane MCM Complex CMG Complex	Chromosome, Telomeric Region Chromatin Heterochromatin Origin Recognition Complex Inner Kinetochore Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Centrosome Membrane
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity	DNA Replication Origin Binding Protein Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Regulation Of DNA-templated DNA Replication Initiation Mitotic DNA Replication Initiation	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA Replication Initiation
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Eosinophil percentage of white cells ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252) Reticulocyte count ( 32888494)	Plasma parathyroid hormone levels ( 30134803) Triptolide cytotoxicity ( 26121980)
Interacting Genes		28 interacting genes: CCNA1 CDC5L CDC7 CDK1 CDK2 CDT1 CEBPA DBF4 EP300 ESCO2 LIG4 MCM2 MCM3 MCM6 MCM7 MCM8 MCMBP ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 SSRP1 SUMO2 SUPT16H TLX2 UBE3A	29 interacting genes: CDC45 CDC5L CDC6 CDK2 CDT1 CTNNA3 DBF4 EP300 H3-4 H4C16 KAT7 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6 RAD18 RFWD3 RIPPLY3 RPA1 RPA2 XRCC5
Entrez ID		4173	4999
HPRD ID		09094	03112
Ensembl ID		ENSG00000104738	ENSG00000115942
Uniprot IDs		B3KMX0 B4DLA6 P33991	Q13416
PDB IDs		6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ	5C8H 5UJ8 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Metabolic Process DNA Replication Initiation Nuclear Origin Of Replication Recognition Complex Regulation Of DNA Replication Nucleic Acid Metabolic Process Origin Recognition Complex Chromosome, Telomeric Region Nucleobase-containing Compound Metabolic Process MCM Complex Nucleoplasm Regulation Of DNA-templated DNA Replication Initiation DNA Replication Origin Binding DNA Repair Nucleus Macromolecule Metabolic Process DNA Damage Response Regulation Of DNA Metabolic Process Double-strand Break Repair Via Break-induced Replication Chromosome CMG Complex Double-strand Break Repair Cellular Response To Stress Positive Regulation Of DNA Replication Positive Regulation Of DNA-templated DNA Replication DNA Binding Single-stranded DNA Helicase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination DNA Recombination Recombinational Repair G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Chromatin Binding ATP Binding Single-stranded DNA Binding Regulation Of Nuclear Cell Cycle DNA Replication DNA-templated DNA Replication Helicase Activity Cyclin A1-CDK1 Complex Cyclin A1-CDK2 Complex Regulation Of Primary Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Division Nucleotide Binding Mitotic DNA Replication Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex	DNA Replication DNA Replication Initiation DNA Metabolic Process DNA Replication Origin Binding Chromosome, Telomeric Region Regulation Of DNA-templated DNA Replication Initiation Regulation Of DNA Replication Nucleic Acid Metabolic Process CMG Complex Double-strand Break Repair Via Break-induced Replication Single-stranded DNA Binding Nucleobase-containing Compound Metabolic Process Recombinational Repair Nuclear Origin Of Replication Recognition Complex Regulation Of DNA Metabolic Process DNA Damage Response DNA Repair Chromosome MCM Complex Double-strand Break Repair Via Homologous Recombination Nucleoplasm Origin Recognition Complex Double-strand Break Repair DNA Recombination DNA Binding Single-stranded DNA Helicase Activity Cellular Response To Stress Nucleus Macromolecule Metabolic Process Helicase Activity Negative Regulation Of Cell Cycle Phase Transition DNA Helicase Activity ATP Hydrolysis Activity Mitotic DNA Replication Initiation Negative Regulation Of Cell Cycle Process DNA Replication Checkpoint Signaling Regulation Of Cell Cycle Phase Transition Damaged DNA Binding Negative Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Signaling ATP Binding Regulation Of Cell Cycle Process Positive Regulation Of DNA Replication Site Of DNA Damage Regulation Of Cell Cycle Protein Localization To Chromosome DNA Replication Factor A Complex DNA Strand Elongation Involved In DNA Replication Positive Regulation Of DNA-templated DNA Replication Mitotic G1 DNA Damage Checkpoint Signaling
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