NSFL1C and SRP14

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		NSFL1C	SRP14
Description		NSFL1 cofactor	signal recognition particle 14
Image
GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Golgi Apparatus Golgi Stack Centrosome Cytosol Cytoskeleton VCP-NSFL1C Complex	Extracellular Region Nucleus Cytoplasm Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Secretory Granule Lumen Signal Recognition Particle Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex
	Molecular Function	Protein Binding Lipid Binding Ubiquitin Binding	RNA Binding Protein Binding 7S RNA Binding Endoplasmic Reticulum Signal Peptide Binding
	Biological Process	Autophagosome Assembly Establishment Of Mitotic Spindle Orientation Ubiquitin-dependent Protein Catabolic Process Golgi Organization Nuclear Membrane Reassembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Centrosome Separation Membrane Fusion Negative Regulation Of Protein Localization To Centrosome	Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane Protein Targeting To ER
Pathways		RHOH GTPase cycle	SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Neutrophil degranulation
Drugs			Artenimol
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Ewing sarcoma ( 22327514) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Obesity-related traits ( 23251661) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		19 interacting genes: ANP32A CDK1 CEBPA DBI FAM32A GLMN GSK3B LIPE NEDD8 NGLY1 PBK PHAX PRKACA RPL22 SRP14 STX5 TARDBP UBC VCP	10 interacting genes: CALM1 CEBPA EAF1 FOXP1 IL7R NSFL1C PTEN SPANXN2 SRP9 UBC
Entrez ID		55968	6727
HPRD ID		09425	02831
Ensembl ID		ENSG00000088833	ENSG00000140319
Uniprot IDs		Q53FE8 Q9UNZ2	P37108
PDB IDs		1SS6 8HRZ	1E8O 1E8S 1RY1 4UYJ 4UYK 5AOX 7NFX
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Nucleocytoplasmic Transport Ubiquitin Protein Ligase Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Protein Transport Regulation Of Nucleocytoplasmic Transport Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Intracellular Transport Golgi Disassembly Regulation Of Intracellular Protein Transport RNA Binding Modification-dependent Protein Catabolic Process Negative Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Organelle Disassembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Metabolic Process Protein Tag Activity Positive Regulation Of Protein Transport Regulation Of Intracellular Transport Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Export From Nucleus Regulation Of Circadian Rhythm Positive Regulation Of Proteasomal Protein Catabolic Process Intracellular Signaling Cassette Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Glutamatergic Synapse Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Catabolic Process Protein Serine Kinase Activity Protein Phosphorylation Macromolecule Metabolic Process Nucleus Regulation Of Osteoblast Differentiation Regulation Of Primary Metabolic Process Regulation Of Protein Localization To Nucleus Negative Regulation Of Smoothened Signaling Pathway Regulation Of Protein Export From Nucleus Phosphorylation Catabolic Process Positive Regulation Of Protein Import Into Nucleus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Receptor Signaling Pathway Via JAK-STAT Nucleoplasm Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Mononuclear Cell Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Regulation Of Cell Size Regulation Of Lymphocyte Apoptotic Process Negative Regulation Of Lymphocyte Apoptotic Process Negative Regulation Of Leukocyte Apoptotic Process Interleukin-7 Receptor Activity Negative Regulation Of Synaptic Vesicle Clustering Membrane Assembly Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Negative Regulation Of Organ Growth Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Interleukin-21 Production VCP-NSFL1C Complex Negative Regulation Of Protein Localization To Centrosome Regulation Of Cell Development
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