EAF1 and HOMER3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, two hybrid)

		EAF1	HOMER3
Description		ELL associated factor 1	homer scaffold protein 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Elongation Factor Complex Cajal Body Nuclear Body Nuclear Speck Super Elongation Complex Intercellular Bridge	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Dendrite Basal Part Of Cell Synapse Glutamatergic Synapse
	Molecular Function	Transcription Elongation Factor Activity Protein Binding	Protein Binding Protein Domain Specific Binding G Protein-coupled Glutamate Receptor Binding Identical Protein Binding
	Biological Process	Transcription Elongation By RNA Polymerase II Regulation Of Transcription Elongation By RNA Polymerase II	Protein Targeting G Protein-coupled Glutamate Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Store-operated Calcium Entry
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS
Interacting Genes		54 interacting genes: AP2M1 APP ARID4B BEND7 CCDC150 CCDC33 CDK9 CEP70 CEP76 DNTTIP1 DPPA4 DRC4 ELL ELL2 FAM228A GADD45GIP1 GCSAML GOLGA6L9 GPRASP3 GRHL3 GTF2H1 GTF2H4 HOMER3 HSF2BP KEAP1 KIAA1328 MAB21L3 MIPOL1 NUMB PAX6 PICK1 PIH1D1 PSME3 RYBP SDCBP SEMG1 SH3RF1 SRP14 STAC3 TCEA2 TFCP2 TFPT TLE5 TNFAIP8 TNNI1 TRAF2 TRIM28 TRIM62 VAX1 YAF2 ZBTB14 ZNF143 ZNF202 ZNF620	90 interacting genes: ABI1 ABI2 ABI3 APP ARL13B C1orf116 C4orf17 CCDC120 CCDC141 CCDC187 CDC37 CDK18 CEBPA CEBPB CFTR CWF19L2 DRC4 DVL3 DYNLL1 DYNLL2 EAF1 EFHC1 EIF3D FAM161B FAM90A1 FAT1 FMR1 FXR1 FXR2 GGN GRM5 HOMER1 HOXB5 INCA1 ITPR1 KANK2 KANK4 KDM1A KRTAP19-7 LHX2 LNX1 LRRC7 LSM14B MDM1 MEOX1 MFAP1 MIA3 MOS MSS51 NEBL NTAQ1 OTX2 PAX6 PAX7 PKN1 PLAAT5 POLI POM121 PPP1R18 PRCC PRR35 PSMA1 PSMA2 PSMC5 PSORS1C2 RBM14 RBM22 RUNX1T1 RYR1 SAXO1 SAXO4 SCNM1 SDCBP SHANK3 SLAIN1 SMR3B SNCA SNRPF SRPK2 TBC1D22B TOX2 TRPC1 TSC1 USP2 WIPF1 ZBTB4 ZNF19 ZNF35 ZNF414 ZNF655
Entrez ID		85403	9454
HPRD ID		12209	07270
Ensembl ID		ENSG00000144597	ENSG00000051128
Uniprot IDs		Q96JC9	Q9NSC5
PDB IDs		7OKX 7OKY	2P8V 3CVF
Enriched GO Terms of Interacting Partners?		Transcription By RNA Polymerase II DNA-templated Transcription Transcription Elongation Factor Complex Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Receptor Internalization TORC1 Complex Assembly Regulation Of RNA Metabolic Process Transcription Elongation By RNA Polymerase II DNA-templated Transcription Elongation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Regulation Of Receptor-mediated Endocytosis Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Receptor Internalization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Elongation Neuroblast Proliferation SnRNA Transcription By RNA Polymerase II Positive Regulation Of Receptor-mediated Endocytosis Transcription Factor TFIIH Core Complex Regulation Of Macromolecule Metabolic Process Transcription Factor TFIIH Holo Complex Negative Regulation Of Neuroblast Proliferation Nucleus Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process SnRNA Transcription Regulation Of Gene Expression Chromatin Remodeling Positive Regulation Of DNA-templated Transcription, Elongation RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of JNK Cascade Regulation Of Macromolecule Biosynthetic Process Central Nervous System Development Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase III	Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Dendritic Spine Cytoplasm Postsynapse Actin-based Cell Projection Postsynaptic Density SCAR Complex C/EBP Complex HMG Box Domain Binding Signaling Adaptor Activity Neuron Projection Growth Cone Filopodium CHOP-C/EBP Complex Cytoplasmic Ribonucleoprotein Granule Filopodium Tip Growth Cone Regulation Of Synaptic Plasticity Translation Regulator Activity Protein Tetramerization Glutamate Receptor Signaling Pathway Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Neurogenesis Cytoskeleton Cytoskeletal Anchor Activity Regulation Of Cytosolic Calcium Ion Concentration RNA Strand Annealing Activity Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Synapse Organization Telencephalon Regionalization Dorsal/ventral Pattern Formation Regulation Of Nervous System Process Regulation Of Cytoskeleton Organization Regulation Of Nervous System Development Intracellular Membraneless Organelle Scaffold Protein Binding Negative Regulation Of Centriole Replication Positive Regulation Of Nervous System Development Regulation Of Synaptic Transmission, Glutamatergic 14-3-3 Protein Binding RNA Splicing Regulation Of Neurogenesis MRNA Splicing, Via Spliceosome Proteasome Core Complex, Alpha-subunit Complex Neuron Spine Regulation Of Cell Projection Organization Developmental Maturation
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