EAF1 and SEMG1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EAF1	SEMG1
Description		ELL associated factor 1	semenogelin 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Elongation Factor Complex Cajal Body Nuclear Body Nuclear Speck Super Elongation Complex Intercellular Bridge	Acrosomal Vesicle Extracellular Region Extracellular Space Nucleus Protein-containing Complex Extracellular Exosome
	Molecular Function	Transcription Elongation Factor Activity Protein Binding	Protein Binding Zinc Ion Binding
	Biological Process	Transcription Elongation By RNA Polymerase II Regulation Of Transcription Elongation By RNA Polymerase II	Insemination Antibacterial Humoral Response Killing Of Cells Of Another Organism Sperm Capacitation Coagulation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Calcium Ion Import Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Flagellated Sperm Motility
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation	Antimicrobial peptides Amyloid fiber formation
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Bipolar disorder ( 31043756) Malaria ( 31844061)
Interacting Genes		54 interacting genes: AP2M1 APP ARID4B BEND7 CCDC150 CCDC33 CDK9 CEP70 CEP76 DNTTIP1 DPPA4 DRC4 ELL ELL2 FAM228A GADD45GIP1 GCSAML GOLGA6L9 GPRASP3 GRHL3 GTF2H1 GTF2H4 HOMER3 HSF2BP KEAP1 KIAA1328 MAB21L3 MIPOL1 NUMB PAX6 PICK1 PIH1D1 PSME3 RYBP SDCBP SEMG1 SH3RF1 SRP14 STAC3 TCEA2 TFCP2 TFPT TLE5 TNFAIP8 TNNI1 TRAF2 TRIM28 TRIM62 VAX1 YAF2 ZBTB14 ZNF143 ZNF202 ZNF620	9 interacting genes: EAF1 KLK2 KLK3 PRKCA PTPRF SEMG2 TGM1 UBQLN2 UBQLN4
Entrez ID		85403	6406
HPRD ID		12209	01641
Ensembl ID		ENSG00000144597	ENSG00000124233
Uniprot IDs		Q96JC9	P04279
PDB IDs		7OKX 7OKY	7ZRF 7ZRO 8BOO 8BVZ
Enriched GO Terms of Interacting Partners?		Transcription By RNA Polymerase II DNA-templated Transcription Transcription Elongation Factor Complex Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Receptor Internalization TORC1 Complex Assembly Regulation Of RNA Metabolic Process Transcription Elongation By RNA Polymerase II DNA-templated Transcription Elongation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Regulation Of Receptor-mediated Endocytosis Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Receptor Internalization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Elongation Neuroblast Proliferation SnRNA Transcription By RNA Polymerase II Positive Regulation Of Receptor-mediated Endocytosis Transcription Factor TFIIH Core Complex Regulation Of Macromolecule Metabolic Process Transcription Factor TFIIH Holo Complex Negative Regulation Of Neuroblast Proliferation Nucleus Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process SnRNA Transcription Regulation Of Gene Expression Chromatin Remodeling Positive Regulation Of DNA-templated Transcription, Elongation RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of JNK Cascade Regulation Of Macromolecule Biosynthetic Process Central Nervous System Development Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase III	Zymogen Activation Extracellular Exosome Proteolysis Protein Metabolic Process Polyubiquitin Modification-dependent Protein Binding Regulation Of Systemic Arterial Blood Pressure Macromolecule Metabolic Process Secretory Granule Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex Chondroitin Sulfate Proteoglycan Binding Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Regulation Of Proteolysis Cell Envelope Organization Autophagosome Negative Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Positive Regulation Of Antibacterial Peptide Production Serine-type Peptidase Activity Protein Kinase C Signaling Negative Regulation Of Receptor Binding Negative Regulation Of Clathrin-dependent Endocytosis Serine-type Endopeptidase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Cellular Response To Stress Cytosolic Proteasome Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Antibacterial Peptide Production Positive Regulation Of Antimicrobial Peptide Production Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Super Elongation Complex Regulation Of Blood Pressure Positive Regulation Of Antimicrobial Humoral Response Desmosome Assembly Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Protein-glutamine Gamma-glutamyltransferase Activity Protein Processing Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Endopeptidase Activity Regulation Of Macroautophagy Transcription Elongation Factor Activity Positive Regulation Of Epithelial Cell Proliferation Regulation Of Proteasomal Protein Catabolic Process
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