EAF1 and GTF2H4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EAF1	GTF2H4
Description		ELL associated factor 1	general transcription factor IIH subunit 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Elongation Factor Complex Cajal Body Nuclear Body Nuclear Speck Super Elongation Complex Intercellular Bridge	Core TFIIH Complex Portion Of Holo TFIIH Complex Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Nuclear Speck
	Molecular Function	Transcription Elongation Factor Activity Protein Binding	ATPase Activator Activity Double-stranded DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity
	Biological Process	Transcription Elongation By RNA Polymerase II Regulation Of Transcription Elongation By RNA Polymerase II	DNA Repair Nucleotide-excision Repair Transcription By RNA Polymerase II DNA Damage Response
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Conotruncal heart defects (maternal effects) ( 28468790) Malaria ( 31844061) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 28991256) Ulcerative colitis ( 20848476)
Interacting Genes		54 interacting genes: AP2M1 APP ARID4B BEND7 CCDC150 CCDC33 CDK9 CEP70 CEP76 DNTTIP1 DPPA4 DRC4 ELL ELL2 FAM228A GADD45GIP1 GCSAML GOLGA6L9 GPRASP3 GRHL3 GTF2H1 GTF2H4 HOMER3 HSF2BP KEAP1 KIAA1328 MAB21L3 MIPOL1 NUMB PAX6 PICK1 PIH1D1 PSME3 RYBP SDCBP SEMG1 SH3RF1 SRP14 STAC3 TCEA2 TFCP2 TFPT TLE5 TNFAIP8 TNNI1 TRAF2 TRIM28 TRIM62 VAX1 YAF2 ZBTB14 ZNF143 ZNF202 ZNF620	13 interacting genes: EAF1 EIF1AD ERCC3 ERCC5 GTF2B GTF2E1 GTF2F1 POLR2A SREK1IP1 TBP TP53 UBC XBP1P1
Entrez ID		85403	2968
HPRD ID		12209	03456
Ensembl ID		ENSG00000144597	ENSG00000213780
Uniprot IDs		Q96JC9	A0A1U9X7S4 Q92759
PDB IDs		7OKX 7OKY	5IVW 5IY6 5IY7 5IY8 5IY9 5OF4 6NMI 6O9L 6O9M 6RO4 7AD8 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVV 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		Transcription By RNA Polymerase II DNA-templated Transcription Transcription Elongation Factor Complex Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Receptor Internalization TORC1 Complex Assembly Regulation Of RNA Metabolic Process Transcription Elongation By RNA Polymerase II DNA-templated Transcription Elongation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Regulation Of Receptor-mediated Endocytosis Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Receptor Internalization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Elongation Neuroblast Proliferation SnRNA Transcription By RNA Polymerase II Positive Regulation Of Receptor-mediated Endocytosis Transcription Factor TFIIH Core Complex Regulation Of Macromolecule Metabolic Process Transcription Factor TFIIH Holo Complex Negative Regulation Of Neuroblast Proliferation Nucleus Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process SnRNA Transcription Regulation Of Gene Expression Chromatin Remodeling Positive Regulation Of DNA-templated Transcription, Elongation RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of JNK Cascade Regulation Of Macromolecule Biosynthetic Process Central Nervous System Development Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase III	Transcription Factor TFIID Complex Transcription Initiation At RNA Polymerase II Promoter Promoter-specific Chromatin Binding DNA-templated Transcription Initiation DNA-templated Transcription RNA Polymerase II General Transcription Initiation Factor Activity Transcription Elongation By RNA Polymerase II Transcription By RNA Polymerase II DNA-templated Transcription Elongation Nucleobase-containing Compound Biosynthetic Process Nucleoplasm RNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Nucleotide-excision Repair RNA Polymerase II General Transcription Initiation Factor Binding MRNA Transcription Macromolecule Metabolic Process Transcription-coupled Nucleotide-excision Repair Transcription Preinitiation Complex Response To UV-C Nucleus Ubiquitin Protein Ligase Binding Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Nuclear Body Response To UV RNA Polymerase II Complex Binding 14-3-3 Protein Binding Protein-DNA Complex Assembly RNA Polymerase II-specific DNA-binding Transcription Factor Binding Molecular Condensate Scaffold Activity Nucleotide-excision Repair Factor 3 Complex Transcriptional Start Site Selection At RNA Polymerase II Promoter RNA Polymerase II Preinitiation Complex Assembly MRNA Transcription By RNA Polymerase II Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition DNA Binding Transcription Preinitiation Complex Assembly Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress P53 Binding Cellular Response To Diamide Damaged DNA Binding RNA Polymerase II Core Complex Assembly Transcription Factor TFIIE Complex TFIIF-class Transcription Factor Complex Binding Transcription Factor TFIIF Complex MRNA Metabolic Process
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