E2F6 and ZFPM2

Number of citations of the paper that reports this interaction (PubMedID 23082233)
45

Data Source:
BioGRID (two hybrid)

		E2F6	ZFPM2
Description		E2F transcription factor 6	zinc finger protein, FOG family member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex MLL1 Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Dimerization Activity	DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis In Utero Embryonic Development Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Right Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Transcription By RNA Polymerase II Gonadal Mesoderm Development Heart Development Cell Differentiation Lung Development Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development
Pathways		G1/S-Specific Transcription Transcriptional Regulation by E2F6	Transcriptional regulation of testis differentiation Factors involved in megakaryocyte development and platelet production
Drugs
Diseases			Tetralogy of Fallot
GWAS		Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Sudden cardiac arrest ( 21658281)	Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Basophil count ( 32888494) Birth weight ( 31043758) Brugada syndrome ( 35210625) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Coronary artery calcification ( 23870195) Coronary artery disease ( 29212778 33020668) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Daytime nap ( 33568662) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma (primary open-angle) ( 22570617) HDL cholesterol levels ( 32203549) HOMA-B (corrected for HOMA-IR) ( 30369944) Impulsivity (attentional) ( 30718321) Mean platelet volume ( 27863252 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Myocardial infarction ( 33532862) Neutrophil count ( 32888494) Platelet count ( 32888494 29403010 33545615 27863252 26805783 22139419) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 27863252 32888494) PR interval ( 30046033 32439900) Red blood cell count ( 32888494) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 28739976) Takayasu arteritis ( 25604533) Tuberculosis ( 24057671) Vascular endothelial growth factor levels ( 21757650 26910538) Venous thromboembolism ( 31676865 31420334 28373160 25772935) White blood cell count ( 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		27 interacting genes: APP ARAF BMI1 BRDT CENPU DNMT1 DNMT3L DNTTIP1 E2F1 EPC1 EZH1 EZH2 HMG20B INO80B KRTAP10-7 NFYA PCGF6 PIK3R3 RING1 RYBP SMARCA4 TFDP1 TFDP2 ZBTB17 ZBTB32 ZFPM2 ZMYND11	13 interacting genes: CTBP1 CTBP2 E2F6 EP300 FMR1 GATA1 GATA3 GATA4 IL32 ITSN1 PRPF3 STAT3 UBQLN4
Entrez ID		1876	23414
HPRD ID		04251	04737
Ensembl ID		ENSG00000169016	ENSG00000169946
Uniprot IDs		A0A0S2Z3K8 O75461 Q53YM3 Q6Q9Z5	E7ET52 Q8WW38 Q9NPQ0
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Biosynthetic Process Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Metabolic Process DNA Binding Constitutive Heterochromatin Formation Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Heterochromatin Formation PcG Protein Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process DNA Methylation-dependent Constitutive Heterochromatin Formation Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Heterochromatin ESC/E(Z) Complex Positive Regulation Of Transcription By RNA Polymerase II PRC1 Complex Regulation Of Cell Cycle Histone H3K27 Trimethyltransferase Activity Nucleosome Binding Negative Regulation Of Fat Cell Proliferation Rb-E2F Complex Zinc Ion Binding	RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Coregulator Binding Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Cell Fate Commitment Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Autophagy Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Male Gonad Development Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Gonad Development Negative Regulation Of Metabolic Process Transcription Coactivator Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Reproductive Structure Development Transcription Repressor Complex Identical Protein Binding Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Positive Regulation Of Developmental Process Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Chromatin DNA Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction T-helper 17 Cell Lineage Commitment Transcription Cis-regulatory Region Binding Cardiac Right Ventricle Morphogenesis Nucleic Acid Metabolic Process Transcription By RNA Polymerase II Negative Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA White Fat Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process T-helper Cell Lineage Commitment Chromatin Viral Genome Replication DNA-binding Transcription Factor Activity CD4-positive, Alpha-beta T Cell Lineage Commitment Fat Cell Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulator Complex Platelet Formation Alpha-beta T Cell Lineage Commitment Embryonic Hemopoiesis
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