E2F6 and BRDT

Number of citations: 45 (PubMedID 23082233)
Data Source: BioGRID (two hybrid)

		E2F6	BRDT
Name		E2F transcription factor 6	bromodomain testis associated
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex MLL1 Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Dimerization Activity	Chromatin Binding Transcription Coactivator Activity Protein Serine/threonine Kinase Activity Protein-macromolecule Adaptor Activity Histone Binding Histone H4 Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II MRNA Processing Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis RNA Splicing Positive Regulation Of Gene Expression Cell Differentiation Sperm DNA Condensation Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription Meiotic Cell Cycle
Pathways		G1/S-Specific Transcription Transcriptional Regulation by E2F6	None
GWAS		Diisocyanate-induced asthma ( 25918132 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Sudden cardiac arrest ( 21658281 )	Gestational age at birth (maternal effect) ( 28877031 ) Height ( 28552196 ) Mean corpuscular hemoglobin concentration ( 32888494 )
Novel Interactors		2 novel interactors: DRD2 MDN1	2 novel interactors: CD276 IDE
Interacting Genes		27 interacting genes: APP ARAF BMI1 BRDT CENPU DNMT1 DNMT3L DNTTIP1 E2F1 EPC1 EZH1 EZH2 HMG20B INO80B KRTAP10-7 NFYA PCGF6 PIK3R3 RING1 RYBP SMARCA4 TFDP1 TFDP2 ZBTB17 ZBTB32 ZFPM2 ZMYND11	3 interacting genes: E2F6 H4C14 VAV2
Entrez ID		1876	676
HPRD ID		04251	03684
Ensembl ID		ENSG00000169016	ENSG00000137948
Uniprot IDs		A0A0S2Z3K8 O75461 Q53YM3 Q6Q9Z5	Q58F21
PDB IDs		Not available	2RFJ 4FLP 4KCX 5VBQ 5VBR 7BJY 7L73 7L99 7L9A 7LEJ 7LEK 7LEL 7LEM 7MRC 7MRD 7MRG 7MRH 7UBO 7UUU 8CZA 8YHS
GO Terms Enriched among Interactors		Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Biosynthetic Process Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Metabolic Process DNA Binding Constitutive Heterochromatin Formation Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Heterochromatin Formation PcG Protein Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process DNA Methylation-dependent Constitutive Heterochromatin Formation Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Heterochromatin ESC/E(Z) Complex Positive Regulation Of Transcription By RNA Polymerase II PRC1 Complex Regulation Of Cell Cycle Histone H3K27 Trimethyltransferase Activity Nucleosome Binding Negative Regulation Of Fat Cell Proliferation Rb-E2F Complex Zinc Ion Binding	None