E2F6 and TFDP1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		E2F6	TFDP1
Description		E2F transcription factor 6	transcription factor Dp-1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex MLL1 Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Rb-E2F Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Dimerization Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Epidermis Development Anoikis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Negative Regulation Of Fat Cell Proliferation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Biosynthetic Process
Pathways		G1/S-Specific Transcription Transcriptional Regulation by E2F6	Activation of NOXA and translocation to mitochondria Inhibition of replication initiation of damaged DNA by RB1/E2F1 Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Activation of PUMA and translocation to mitochondria G0 and Early G1 Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Oxidative Stress Induced Senescence Oncogene Induced Senescence TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by E2F6 Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Sudden cardiac arrest ( 21658281)	Height ( 31562340) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mild influenza (H1N1) infection ( 26379185)
Interacting Genes		27 interacting genes: APP ARAF BMI1 BRDT CENPU DNMT1 DNMT3L DNTTIP1 E2F1 EPC1 EZH1 EZH2 HMG20B INO80B KRTAP10-7 NFYA PCGF6 PIK3R3 RING1 RYBP SMARCA4 TFDP1 TFDP2 ZBTB17 ZBTB32 ZFPM2 ZMYND11	20 interacting genes: CDK1 CDK2 CDK6 CDKN2A CREBBP CRYAA E2F1 E2F2 E2F3 E2F4 E2F5 E2F6 NPDC1 OGT SERTAD2 SIAH1 SOCS3 TP53 TP53BP1 UBC
Entrez ID		1876	7027
HPRD ID		04251	01792
Ensembl ID		ENSG00000169016	ENSG00000198176
Uniprot IDs		A0A0S2Z3K8 O75461 Q53YM3 Q6Q9Z5	Q14186
PDB IDs			2AZE 5GOW 5TUU 5TUV
Enriched GO Terms of Interacting Partners?		Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Biosynthetic Process Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Metabolic Process DNA Binding Constitutive Heterochromatin Formation Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Heterochromatin Formation PcG Protein Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process DNA Methylation-dependent Constitutive Heterochromatin Formation Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Heterochromatin ESC/E(Z) Complex Positive Regulation Of Transcription By RNA Polymerase II PRC1 Complex Regulation Of Cell Cycle Histone H3K27 Trimethyltransferase Activity Nucleosome Binding Negative Regulation Of Fat Cell Proliferation Rb-E2F Complex Zinc Ion Binding	Transcription Regulator Complex Nucleoplasm RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Activator Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein Dimerization Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Cell Cycle DNA Damage Checkpoint Signaling Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Signal Transduction In Response To DNA Damage P53 Binding Regulation Of Gene Expression Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Cis-regulatory Region Sequence-specific DNA Binding Cell Cycle G1/S Phase Transition Apoptotic Process Cyclin-dependent Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Cycle Phase Transition Programmed Cell Death Cell Death DNA-binding Transcription Factor Activity Negative Regulation Of Transcription By RNA Polymerase II Cyclin Binding Lens Fiber Cell Apoptotic Process Regulation Of DNA Replication Intracellular Signal Transduction Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cell Cycle Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Fat Cell Proliferation Rb-E2F Complex Negative Regulation Of Cell Cycle Process
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