KRAS and SHOC2

Number of citations of the paper that reports this interaction (PMID 9674433)
37

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		KRAS	SHOC2
Gene Name		Kirsten rat sarcoma viral oncogene homolog	soc-2 suppressor of clear homolog (C. elegans)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Focal Adhesion Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Membrane Raft	Protein Phosphatase Type 1 Complex Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding GTP Binding GMP Binding GDP Binding LRR Domain Binding Protein Complex Binding	Protein Phosphatase Regulator Activity Protein Phosphatase Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Positive Regulation Of Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Actin Cytoskeleton Organization Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Rac Protein Signal Transduction Social Behavior Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Negative Regulation Of Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Leukocyte Migration Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Striated Muscle Cell Differentiation Response To Glucocorticoid Response To Mineralocorticoid Epithelial Tube Branching Involved In Lung Morphogenesis	Ras Protein Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Ras Protein Signal Transduction Regulation Of Catalytic Activity
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease SHC-mediated cascade MEK activation FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Gastrin-CREB signalling pathway via PKC and MAPK p38MAPK events SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Downstream signal transduction Signalling to RAS Signaling by FGFR mutants Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Adaptive Immune System Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R EGFR Transactivation by Gastrin GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation RAF phosphorylates MEK Downstream signaling of activated FGFR NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR ARMS-mediated activation RAF activation SHC1 events in EGFR signaling IRS-mediated signalling Activation of RAS in B cells FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Constitutive Signaling by EGFRvIII
Drugs
Diseases
GWAS
Protein-Protein Interactions		35 interactors: ADH6 APP ARAF BCL2 CALM1 CCT7 DDX47 DDX50 DNAJA3 EEF1A1 EGLN1 EPB42 FNTA FNTB HNRNPC IGSF21 LPAR1 MDFI PDE4DIP PGGT1B PIK3CA PIK3CG PIK3R2 PSMA3 RAF1 RALGDS RAP1GDS1 RASGRF2 RASGRP2 RASSF2 RASSF5 RBPMS RGL2 SHOC2 ZDHHC17	6 interactors: APP ERBB2IP HRAS KRAS NRAS RAF1
Entrez ID		3845	8036
HPRD ID		01817	04144
Ensembl ID		ENSG00000133703	ENSG00000108061
Uniprot IDs		L7RSL8 P01116	Q9UQ13
PDB IDs		1D8D 1D8E 1KZO 1KZP 3GFT 4DSN 4DSO 4EPR 4EPT 4EPV 4EPW 4EPX 4EPY
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Stimulus Signal Transduction Regulation Of Phosphorus Metabolic Process Signaling Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Cell Communication Response To Stimulus Regulation Of Phosphorylation Response To Growth Factor Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Platelet Activation Response To Wounding Positive Regulation Of Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Cellular Metabolic Process Neurotrophin Signaling Pathway Programmed Cell Death Positive Regulation Of Hydrolase Activity Regulation Of Kinase Activity Regulation Of Cellular Amino Acid Metabolic Process Cell Death Death Protein Prenylation Wound Healing Blood Coagulation Small GTPase Mediated Signal Transduction Hemostasis Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Response To Organic Substance Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process	Positive Regulation Of Rac Protein Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Visual Learning Visual Behavior Activation Of MAPKK Activity Associative Learning Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Guidance Blood Coagulation Hemostasis Learning Insulin Receptor Signaling Pathway Axonogenesis Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Synaptic Transmission, GABAergic Wound Healing Chemotaxis Response To Fibroblast Growth Factor Regulation Of Rac Protein Signal Transduction Neuron Projection Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway MAPK Cascade Response To Wounding Epithelial Tube Branching Involved In Lung Morphogenesis Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Learning Or Memory Positive Regulation Of Ras Protein Signal Transduction Fc Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Neuronal Synaptic Plasticity Activation Of Protein Kinase Activity Innate Immune Response Signal Transduction By Phosphorylation Neuron Projection Development Response To Insulin Cognition Positive Regulation Of Small GTPase Mediated Signal Transduction
Tagcloud ?		bitransgenic coexpressed coexpression contributions cooperate crypt d11137 dedifferentiation describing dysplastic enterocyte enterocytes expresses geographically oncoproteins organized p107 perturb postmitotic reenter retains simian sv40 tag tagd11137 tagwt val val12 villus	aortic associates biopsies cardiac cardiomyocytes clear clearly constriction decompensated died elucidated erbb2 erbin erk explored failing heart hearts homolog hypertrophy interacting isoproterenol modulating overload participates raf rapidly soc widely
Tagcloud (Difference) ?		bitransgenic coexpressed coexpression contributions cooperate crypt d11137 dedifferentiation describing dysplastic enterocyte enterocytes expresses geographically oncoproteins organized p107 perturb postmitotic reenter retains simian sv40 tag tagd11137 tagwt val val12 villus	aortic associates biopsies cardiac cardiomyocytes clear clearly constriction decompensated died elucidated erbb2 erbin erk explored failing heart hearts homolog hypertrophy interacting isoproterenol modulating overload participates raf rapidly soc widely
Tagcloud (Intersection) ?