KRAS and RAF1

Number of citations of the paper that reports this interaction (PubMedID 9446616)
0

Data Source:
HPRD (in vitro)

		KRAS	RAF1
Description		KRAS proto-oncogene, GTPase	Raf-1 proto-oncogene, serine/threonine kinase
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Side Of Plasma Membrane Endomembrane System Membrane	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane Pseudopodium
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GMP Binding GDP Binding LRR Domain Binding Identical Protein Binding Protein-membrane Adaptor Activity Protein-containing Complex Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Adenylate Cyclase Activator Activity Kinase Activity Transferase Activity Enzyme Binding Small GTPase Binding Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Liver Development Signal Transduction Ras Protein Signal Transduction Female Pregnancy Cell Population Proliferation Visual Learning Response To Gravity Gene Expression Positive Regulation Of Gene Expression Glial Cell Proliferation Rac Protein Signal Transduction Cytokine-mediated Signaling Pathway Forebrain Astrocyte Development Actin Cytoskeleton Organization Negative Regulation Of Epithelial Cell Differentiation Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Rac Protein Signal Transduction Response To Isolation Stress Skeletal Muscle Cell Differentiation Negative Regulation Of Neuron Apoptotic Process Regulation Of Long-term Neuronal Synaptic Plasticity Homeostasis Of Number Of Cells Within A Tissue Striated Muscle Cell Differentiation Response To Glucocorticoid Response To Mineralocorticoid Neuron Apoptotic Process Myoblast Proliferation Cardiac Muscle Cell Proliferation Positive Regulation Of Glial Cell Proliferation Epithelial Tube Branching Involved In Lung Morphogenesis Type I Pneumocyte Differentiation Positive Regulation Of Cellular Senescence	MAPK Cascade Intracellular Glucose Homeostasis Protein Phosphorylation Apoptotic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Schwann Cell Development Cell Differentiation Thyroid Gland Development Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Somatic Stem Cell Population Maintenance Regulation Of Rho Protein Signal Transduction Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Muscle Stretch ERBB2-ERBB3 Signaling Pathway Wound Healing Myelination Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Type B Pancreatic Cell Proliferation Intermediate Filament Cytoskeleton Organization Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Insulin-like Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Thymus Development Face Development Type II Interferon-mediated Signaling Pathway Death-inducing Signaling Complex Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF RUNX3 regulates p14-ARF RAS processing Signaling downstream of RAS mutants Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells Signaling by RAS GAP mutants Signaling by RAS GTPase mutants	Stimuli-sensing channels Rap1 signalling GP1b-IX-V activation signalling CD209 (DC-SIGN) signaling RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling IFNG signaling activates MAPKs
Drugs		[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Farnesyl diphosphate Adagrasib Sotorasib	Sorafenib LErafAON XL281 iCo-007 Cholecystokinin Regorafenib Dabrafenib Fostamatinib
Diseases		Acute myeloid leukemia (AML) Oral cancer Non-small cell lung cancer Multiple myeloma Cervical cancer Kaposi's sarcoma Cholangiocarcinoma Gallbladder cancer Gastric cancer Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS) Ovarian cancer Hepatocellular carcinoma Thyroid cancer Squamous cell carcinoma Colorectal cancer Endometrial Cancer Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome Pancreatic cancer
GWAS		Alanine aminotransferase levels ( 33547301) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Dysmenorrheic pain ( 27454463) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)	A body shape index ( 34021172) Asthma ( 32296059) Cardiac hypertrophy ( 21348951) Carotid intima media thickness x smoking interaction ( 32117412) Cholesterol, total ( 20686565 24097068) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol levels ( 32203549) Hip index ( 34021172) Total cholesterol levels ( 28334899) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		63 interacting genes: ADH6 ARL6IP5 BCAS3 BCL2 CALM1 CCL5 CCT7 CDK8 DDX47 DDX50 DIRAS3 DNAJA3 EGLN1 EPB42 FANCC FNTA FNTB FRAT2 HEMGN HNRNPC HRAS IGFBP3 IGSF21 IL24 LPAR1 LYPD4 LZTR1 MDFI MOCS2 MT-CO3 MT-CYB NDUFA13 NEDD4 OSGIN1 PDE4DIP PGGT1B PIK3CA PIK3CG PIK3R2 PIP5K1A PPP2CB PSMA3 QDPR RAF1 RALGDS RAP1GDS1 RASGRF2 RASGRP2 RASSF2 RASSF5 RBPMS RGL2 RNF141 SERPINB5 SHOC2 SOX4 STX17 THRSP TNFSF13 UQCRC1 WDR76 ZDHHC17 ZNF189	161 interacting genes: ABCB5 ADCY6 AGTR1 AKT1 AR ARNT ARRB2 BAD BAG1 BCL2 BCL2L1 BCL6 BECN1 BIRC2 BIRC3 BRAF CASZ1 CBLC CCND2 CCT3 CD44 CDC25A CDC37 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CFLAR CNKSR1 COPS3 COPS7A CPS1 DCAF8 DMPK EFEMP1 ERBB2 ERBIN FGFR4 FYCO1 FYN GLIS2 GNB2 GNG4 GRB10 GRM1 HECTD3 HERC1 HGF HRAS HSP90AA1 HSP90AB1 HSPA4 HSPA8 IL2RB INSR INTS10 ITCH JAK1 JAK2 KEAP1 KRAS KRT18 KRT8 KSR1 KSR2 LATS2 LCK LRPAP1 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MAP2K6 MAP3K1 MAP3K5 MAPK1 MAPK3 MAPK7 MAPK8 MAPK8IP3 MBP MET MRAS MRC2 MYBPC1 MYC NEDD4 NF1 NF2 NPLOC4 NR3C1 NRAS NUDT14 OIP5 PACSIN3 PAK1 PAK2 PAK3 PBK PDGFRA PDGFRB PDLIM2 PEBP1 PEBP4 PEX5L PHB1 PHKA2 PIN1 PKM PPP1CC PPP2CB PRKAA1 PRKACA PRKAR1A PRKCA PRKCD PRKCE PRKCZ PRKG1 PRPF6 RANBP9 RAP1A RAP2A RASD2 RASSF1 RB1 RBBP8 RBL2 RFXANK RHEB RRAS RRAS2 RSU1 SFN SHOC2 SPRY2 SPRY4 SRC STK26 STK3 STUB1 TBXA2R TEAD2 TERT TIMM50 TMEM70 TRIM22 TSC22D3 UBE2D2 USP7 VAV1 VDAC1 WEE2-AS1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAZ YY1
Entrez ID		3845	5894
HPRD ID		01817	01265
Ensembl ID		ENSG00000133703	ENSG00000132155
Uniprot IDs		I1SRC5 L7RSL8 P01116	A0A0S2Z4L5 A0A0S2Z559 B4E0X2 L7RRS6 P04049
PDB IDs		1D8D 1D8E 1KZO 1KZP 1N4P 1N4Q 1N4R 1N4S 2MSC 2MSD 2MSE 3GFT 4DSN 4DSO 4EPR 4EPT 4EPV 4EPW 4EPX 4EPY 4L8G 4LDJ 4LPK 4LRW 4LUC 4LV6 4LYF 4LYH 4LYJ 4M1O 4M1S 4M1T 4M1W 4M1Y 4M21 4M22 4NMM 4OBE 4PZY 4PZZ 4Q01 4Q02 4Q03 4QL3 4TQ9 4TQA 4WA7 5F2E 5KYK 5MLA 5MLB 5O2S 5O2T 5OCG 5OCO 5OCT 5TAR 5TB5 5UFE 5UFQ 5UK9 5UQW 5US4 5USJ 5V6S 5V6V 5V71 5V9L 5V9O 5V9U 5VBM 5VP7 5VPI 5VPY 5VPZ 5VQ0 5VQ1 5VQ2 5VQ6 5VQ8 5W22 5WHA 5WHB 5WHD 5WHE 5WLB 5WPM 5XCO 5YXZ 5YY1 6ARK 6ASA 6ASE 6B0V 6B0Y 6BOF 6BP1 6CC9 6CCH 6CCX 6CU6 6E6F 6E6G 6EPL 6EPM 6EPN 6EPO 6EPP 6F76 6FA1 6FA2 6FA3 6FA4 6GJ5 6GJ6 6GJ7 6GJ8 6GOD 6GOE 6GOF 6GOG 6GOM 6GQT 6GQW 6GQX 6GQY 6H46 6H47 6JTN 6JTO 6JTP 6M9W 6MBQ 6MBT 6MBU 6MNX 6MQG 6MQN 6MS9 6MTA 6N2J 6N2K 6O36 6O46 6O4Y 6O4Z 6O51 6O53 6OB2 6OB3 6OIM 6P0Z 6P8W 6P8X 6P8Y 6P8Z 6PGO 6PGP 6PQ3 6PTS 6PTW 6QUU 6QUV 6QUW 6QUX 6T5B 6T5U 6T5V 6TAM 6TAN 6USX 6USZ 6UT0 6V5L 6V65 6V6F 6VC8 6VJJ 6W4E 6W4F 6WGN 6WS2 6WS4 6XGU 6XGV 6XHA 6XHB 6YR8 6YXW 6ZL5 6ZLI 7A1W 7A1X 7A1Y 7A47 7ACA 7ACF 7ACH 7ACQ 7C40 7C41 7EW9 7EWA 7EWB 7EYX 7F0W 7KFZ 7KMR 7KYZ 7LC1 7LC2 7LGI 7LZ5 7MDP 7MQU 7NY8 7O70 7OK3 7OK4 7OO7 7Q9U 7R0M 7R0N 7R0Q 7ROV 7RP2 7RP3 7RP4 7RPZ 7RSC 7RSE 7RT1 7RT2 7RT3 7RT4 7RT5 7SCW 7SCX 7STF 7T1F 7T47 7TLE 7TLG 7TLK 7U8H 7VVB 7W5R 7YCC 7YCE 7YUZ 7YV1 8AFB 8AFC 8AFD 8AQ5 8AQ7 8AZR 8AZV 8AZX 8AZY 8AZZ 8B00 8B69 8B6I 8B78 8BE3 8BE4 8BE5 8BLR 8CPR 8CX5 8DGS 8DGT 8DNI 8DNJ 8DNK 8DVG 8EBZ 8ECR 8EDY 8EER 8EIE 8EPW 8EZG 8F0M 8FMI 8FMJ 8FMK 8G42 8G47 8G4F 8G4H 8G9P 8G9Q 8I5C 8I5D 8I5E 8JGD 8JHL 8JJS 8K4T 8K4V 8K50 8ONV 8PI0 8PIY 8QU8 8QUG 8QVU 8QW6 8QW7 8R7W 8R7X 8RNI 8RRO 8S8C 8STM 8STN 8T4V 8T71 8T72 8T73 8T74 8T75 8TBF 8TBH 8TBJ 8TBK 8TBL 8TBM 8TBN 8TVK 8TXE 8TXG 8TXH 8TXJ 8TXK 8TY2 8TY8 8TY9 8UDR 8UN3 8UN4 8UN5 8V39 8V3A 8VGQ 8VJZ 8VR9 8VRA 8VRB 8WTE 8WUL 8X6R 8YIV 8YJ2 9AX6 9BFW 9BFY 9BFZ 9BG1 9BHO 9BHP 9BHQ 9BI1 9BI2 9C15 9E5D 9E5F 9E9H 9E9I 9KPM 9KPN	1C1Y 1FAQ 1FAR 1GUA 1RFA 3CU8 3IQJ 3IQU 3IQV 3KUC 3KUD 3NKX 3O8I 3OMV 4FJ3 4G0N 4G3X 4IEA 4IHL 6NTC 6NTD 6PTS 6PTW 6VJJ 6XGU 6XGV 6XHA 6XHB 6XI7 7JHP 7Z37 7Z38 8A68 8A6F 8A6H 8ATR 8ATS 8AV0 8CHF 8CPD 8EPW 8GAE 8GFT 8JOF 8JOG 8S42 8T74 8T75 8U1L 9AXA 9AXC 9AY7 9AYA
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Protein Prenyltransferase Activity Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of MAPK Cascade Protein Prenylation Phosphatidylinositol 3-kinase Complex, Class IA GTPase Regulator Activity Prenyltransferase Activity Acetyltransferase Activator Activity Channel Inhibitor Activity Regulation Of Cell Communication Regulation Of Signaling CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Protein Farnesyltransferase Activity Protein Farnesyltransferase Complex Ras Protein Signal Transduction Signal Transduction Protein Farnesylation Positive Regulation Of Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Programmed Cell Death Protein Geranylgeranyltransferase Activity Phosphatidylinositol 3-kinase Complex, Class IB Cytoplasm Glial Cell Development Adenylate Cyclase Activator Activity Quinol-cytochrome-c Reductase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Apoptotic Process Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Programmed Cell Death Protein Geranylgeranylation Insulin Receptor Signaling Pathway Autophagosome Membrane Docking 1-phosphatidylinositol-4-phosphate 3-kinase Activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Intracellular Glucose Homeostasis Neuromuscular Junction Development Apoptotic Process Phosphatidylinositol 3-kinase Complex Negative Regulation Of Fibroblast Apoptotic Process Protein Phosphatase Binding	Intracellular Signal Transduction Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Signal Transduction Regulation Of MAPK Cascade MAPK Cascade Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Protein Kinase Activity Cytosol Kinase Activity Nucleotide Binding Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Serine Kinase Activity Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process ATP Binding Protein Serine/threonine Kinase Activity Regulation Of Protein Metabolic Process Protein Phosphorylation Protein Kinase Binding Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Cellular Component Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphorylation Positive Regulation Of MAPK Cascade Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein Modification Process Regulation Of Metabolic Process Protein Tyrosine Kinase Activity Negative Regulation Of Intracellular Signal Transduction Transferase Activity Regulation Of Multicellular Organismal Process Cellular Response To Stress Regulation Of Developmental Process Cytoplasm Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Localization Regulation Of Primary Metabolic Process
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