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KRAS and HNRNPC
Number of citations of the paper that reports this interaction (PubMedID
37682707
)
0
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(two hybrid)
KRAS
HNRNPC
Description
KRAS proto-oncogene, GTPase
heterogeneous nuclear ribonucleoprotein C
Image
GO Annotations
Cellular Component
Golgi Membrane
Cytoplasm
Mitochondrial Outer Membrane
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Focal Adhesion
Cytoplasmic Side Of Plasma Membrane
Endomembrane System
Membrane
Chromatin
Extracellular Region
Nucleus
Nucleoplasm
Spliceosomal Complex
Telomerase Holoenzyme Complex
Cytosol
Actin Cytoskeleton
Membrane
Protein-containing Complex
Extracellular Exosome
Catalytic Step 2 Spliceosome
Ribonucleoprotein Complex
Molecular Function
Nucleotide Binding
GTPase Activity
G Protein Activity
Protein Binding
GTP Binding
Hydrolase Activity
GMP Binding
GDP Binding
LRR Domain Binding
Identical Protein Binding
Protein-membrane Adaptor Activity
Protein-containing Complex Binding
Nucleic Acid Binding
RNA Binding
MRNA 3'-UTR Binding
Protein Binding
Poly(U) RNA Binding
Nucleosomal DNA Binding
Identical Protein Binding
Telomerase RNA Binding
N6-methyladenosine-containing RNA Reader Activity
Biological Process
MAPK Cascade
Liver Development
Signal Transduction
Ras Protein Signal Transduction
Female Pregnancy
Cell Population Proliferation
Visual Learning
Response To Gravity
Gene Expression
Positive Regulation Of Gene Expression
Glial Cell Proliferation
Rac Protein Signal Transduction
Cytokine-mediated Signaling Pathway
Forebrain Astrocyte Development
Actin Cytoskeleton Organization
Negative Regulation Of Epithelial Cell Differentiation
Regulation Of Synaptic Transmission, GABAergic
Positive Regulation Of Rac Protein Signal Transduction
Response To Isolation Stress
Skeletal Muscle Cell Differentiation
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Long-term Neuronal Synaptic Plasticity
Homeostasis Of Number Of Cells Within A Tissue
Striated Muscle Cell Differentiation
Response To Glucocorticoid
Response To Mineralocorticoid
Neuron Apoptotic Process
Myoblast Proliferation
Cardiac Muscle Cell Proliferation
Positive Regulation Of Glial Cell Proliferation
Epithelial Tube Branching Involved In Lung Morphogenesis
Type I Pneumocyte Differentiation
Positive Regulation Of Cellular Senescence
MRNA Splicing, Via Spliceosome
Osteoblast Differentiation
Chromatin Remodeling
MRNA Processing
RNA Splicing
Negative Regulation Of Telomere Maintenance Via Telomerase
3'-UTR-mediated MRNA Stabilization
Pathways
Signaling by moderate kinase activity BRAF mutants
Paradoxical activation of RAF signaling by kinase inactive BRAF
RUNX3 regulates p14-ARF
RAS processing
Signaling downstream of RAS mutants
Signaling by CSF3 (G-CSF)
Signaling by CSF1 (M-CSF) in myeloid cells
Signaling by RAS GAP mutants
Signaling by RAS GTPase mutants
SUMOylation of RNA binding proteins
mRNA Splicing - Major Pathway
Processing of Capped Intron-Containing Pre-mRNA
RHOBTB2 GTPase cycle
RHOBTB1 GTPase cycle
Drugs
[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID
Farnesyl diphosphate
Adagrasib
Sotorasib
Diseases
Acute myeloid leukemia (AML)
Oral cancer
Non-small cell lung cancer
Multiple myeloma
Cervical cancer
Kaposi's sarcoma
Cholangiocarcinoma
Gallbladder cancer
Gastric cancer
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
Ovarian cancer
Hepatocellular carcinoma
Thyroid cancer
Squamous cell carcinoma
Colorectal cancer
Endometrial Cancer
Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
Pancreatic cancer
GWAS
Alanine aminotransferase levels (
33547301
)
Disease progression in age-related macular degeneration (adjusted for baseline) (
29346644
)
Dysmenorrheic pain (
27454463
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Bipolar disorder (
21738484
31043756
)
Height (
31562340
)
Interacting Genes
63 interacting genes:
ADH6
ARL6IP5
BCAS3
BCL2
CALM1
CCL5
CCT7
CDK8
DDX47
DDX50
DIRAS3
DNAJA3
EGLN1
EPB42
FANCC
FNTA
FNTB
FRAT2
HEMGN
HNRNPC
HRAS
IGFBP3
IGSF21
IL24
LPAR1
LYPD4
LZTR1
MDFI
MOCS2
MT-CO3
MT-CYB
NDUFA13
NEDD4
OSGIN1
PDE4DIP
PGGT1B
PIK3CA
PIK3CG
PIK3R2
PIP5K1A
PPP2CB
PSMA3
QDPR
RAF1
RALGDS
RAP1GDS1
RASGRF2
RASGRP2
RASSF2
RASSF5
RBPMS
RGL2
RNF141
SERPINB5
SHOC2
SOX4
STX17
THRSP
TNFSF13
UQCRC1
WDR76
ZDHHC17
ZNF189
59 interacting genes:
AP1M1
BARD1
BRCA1
BRCA2
BRIP1
CCDC85B
CDKN2A
CSNK1A1
CSNK2A1
CSNK2A2
DHX9
DISC1
DLG4
EPS8
ERG
ESR1
FAS
FXR2
GRB2
IL7R
KHDRBS3
KPNA2
KPNA3
KPNA4
KPNA5
KRAS
LMO2
LMO3
MAPT
MEOX2
NUFIP2
OGT
PALB2
PAX6
PDGFB
PHKB
PIN1
PJA1
PRKDC
PTBP2
RAD51
RALYL
RBM41
RBPMS2
SDCBP
SF3B2
SMARCD1
SREK1
SRPK2
SUMO1
SUMO1P1
TRAF3
UBE2I
USP7
WEE2-AS1
YWHAE
YWHAQ
ZFYVE26
ZNF581
Entrez ID
3845
3183
HPRD ID
01817
01243
Ensembl ID
ENSG00000133703
ENSG00000092199
Uniprot IDs
I1SRC5
L7RSL8
P01116
P07910
PDB IDs
1D8D
1D8E
1KZO
1KZP
1N4P
1N4Q
1N4R
1N4S
2MSC
2MSD
2MSE
3GFT
4DSN
4DSO
4EPR
4EPT
4EPV
4EPW
4EPX
4EPY
4L8G
4LDJ
4LPK
4LRW
4LUC
4LV6
4LYF
4LYH
4LYJ
4M1O
4M1S
4M1T
4M1W
4M1Y
4M21
4M22
4NMM
4OBE
4PZY
4PZZ
4Q01
4Q02
4Q03
4QL3
4TQ9
4TQA
4WA7
5F2E
5KYK
5MLA
5MLB
5O2S
5O2T
5OCG
5OCO
5OCT
5TAR
5TB5
5UFE
5UFQ
5UK9
5UQW
5US4
5USJ
5V6S
5V6V
5V71
5V9L
5V9O
5V9U
5VBM
5VP7
5VPI
5VPY
5VPZ
5VQ0
5VQ1
5VQ2
5VQ6
5VQ8
5W22
5WHA
5WHB
5WHD
5WHE
5WLB
5WPM
5XCO
5YXZ
5YY1
6ARK
6ASA
6ASE
6B0V
6B0Y
6BOF
6BP1
6CC9
6CCH
6CCX
6CU6
6E6F
6E6G
6EPL
6EPM
6EPN
6EPO
6EPP
6F76
6FA1
6FA2
6FA3
6FA4
6GJ5
6GJ6
6GJ7
6GJ8
6GOD
6GOE
6GOF
6GOG
6GOM
6GQT
6GQW
6GQX
6GQY
6H46
6H47
6JTN
6JTO
6JTP
6M9W
6MBQ
6MBT
6MBU
6MNX
6MQG
6MQN
6MS9
6MTA
6N2J
6N2K
6O36
6O46
6O4Y
6O4Z
6O51
6O53
6OB2
6OB3
6OIM
6P0Z
6P8W
6P8X
6P8Y
6P8Z
6PGO
6PGP
6PQ3
6PTS
6PTW
6QUU
6QUV
6QUW
6QUX
6T5B
6T5U
6T5V
6TAM
6TAN
6USX
6USZ
6UT0
6V5L
6V65
6V6F
6VC8
6VJJ
6W4E
6W4F
6WGN
6WS2
6WS4
6XGU
6XGV
6XHA
6XHB
6YR8
6YXW
6ZL5
6ZLI
7A1W
7A1X
7A1Y
7A47
7ACA
7ACF
7ACH
7ACQ
7C40
7C41
7EW9
7EWA
7EWB
7EYX
7F0W
7KFZ
7KMR
7KYZ
7LC1
7LC2
7LGI
7LZ5
7MDP
7MQU
7NY8
7O70
7OK3
7OK4
7OO7
7Q9U
7R0M
7R0N
7R0Q
7ROV
7RP2
7RP3
7RP4
7RPZ
7RSC
7RSE
7RT1
7RT2
7RT3
7RT4
7RT5
7SCW
7SCX
7STF
7T1F
7T47
7TLE
7TLG
7TLK
7U8H
7VVB
7W5R
7YCC
7YCE
7YUZ
7YV1
8AFB
8AFC
8AFD
8AQ5
8AQ7
8AZR
8AZV
8AZX
8AZY
8AZZ
8B00
8B69
8B6I
8B78
8BE3
8BE4
8BE5
8BLR
8CPR
8CX5
8DGS
8DGT
8DNI
8DNJ
8DNK
8DVG
8EBZ
8ECR
8EDY
8EER
8EIE
8EPW
8EZG
8F0M
8FMI
8FMJ
8FMK
8G42
8G47
8G4F
8G4H
8G9P
8G9Q
8I5C
8I5D
8I5E
8JGD
8JHL
8JJS
8K4T
8K4V
8K50
8ONV
8PI0
8PIY
8QU8
8QUG
8QVU
8QW6
8QW7
8R7W
8R7X
8RNI
8RRO
8S8C
8STM
8STN
8T4V
8T71
8T72
8T73
8T74
8T75
8TBF
8TBH
8TBJ
8TBK
8TBL
8TBM
8TBN
8TVK
8TXE
8TXG
8TXH
8TXJ
8TXK
8TY2
8TY8
8TY9
8UDR
8UN3
8UN4
8UN5
8V39
8V3A
8VGQ
8VJZ
8VR9
8VRA
8VRB
8WTE
8WUL
8X6R
8YIV
8YJ2
9AX6
9BFW
9BFY
9BFZ
9BG1
9BHO
9BHP
9BHQ
9BI1
9BI2
9C15
9E5D
9E5F
9E9H
9E9I
9KPM
9KPN
1TXP
1WF2
2MXY
2MZ1
3LN4
Enriched GO Terms of Interacting Partners
?
Regulation Of Intracellular Signal Transduction
Intracellular Signaling Cassette
Protein Prenyltransferase Activity
Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of MAPK Cascade
Protein Prenylation
Phosphatidylinositol 3-kinase Complex, Class IA
GTPase Regulator Activity
Prenyltransferase Activity
Acetyltransferase Activator Activity
Channel Inhibitor Activity
Regulation Of Cell Communication
Regulation Of Signaling
CAAX-protein Geranylgeranyltransferase Activity
CAAX-protein Geranylgeranyltransferase Complex
Protein Farnesyltransferase Activity
Protein Farnesyltransferase Complex
Ras Protein Signal Transduction
Signal Transduction
Protein Farnesylation
Positive Regulation Of Intracellular Signal Transduction
Small GTPase-mediated Signal Transduction
Regulation Of Programmed Cell Death
Protein Geranylgeranyltransferase Activity
Phosphatidylinositol 3-kinase Complex, Class IB
Cytoplasm
Glial Cell Development
Adenylate Cyclase Activator Activity
Quinol-cytochrome-c Reductase Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of Apoptotic Process
Regulation Of Smooth Muscle Cell Migration
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Programmed Cell Death
Protein Geranylgeranylation
Insulin Receptor Signaling Pathway
Autophagosome Membrane Docking
1-phosphatidylinositol-4-phosphate 3-kinase Activity
1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
Intracellular Glucose Homeostasis
Neuromuscular Junction Development
Apoptotic Process
Phosphatidylinositol 3-kinase Complex
Negative Regulation Of Fibroblast Apoptotic Process
Protein Phosphatase Binding
Nuclear Ubiquitin Ligase Complex
Nucleus
Macromolecule Metabolic Process
RNA Binding
Nucleic Acid Metabolic Process
Protein Localization To Organelle
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Regulation Of Primary Metabolic Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Metabolic Process
Regulation Of Signal Transduction
Regulation Of RNA Metabolic Process
NLS-dependent Protein Nuclear Import Complex
Intracellular Signal Transduction
Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Double-strand Break Repair
Regulation Of Cell Communication
Regulation Of Signaling
BRCA1-B Complex
DNA Metabolic Process
DNA Repair
DNA Recombination
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Identical Protein Binding
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
DNA Damage Response
Regulation Of Cell Cycle
Nuclear Body Organization
Double-strand Break Repair Via Homologous Recombination
Regulation Of Macromolecule Biosynthetic Process
Recombinational Repair
Nuclear Import Signal Receptor Activity
Cytosol
Regulation Of DNA Metabolic Process
Nuclear Localization Sequence Binding
Regulation Of Cell Cycle Process
Regulation Of DNA Damage Checkpoint
Regulation Of DNA-templated Transcription
Response To Stress
Regulation Of RNA Biosynthetic Process
NLS-bearing Protein Import Into Nucleus
Regulation Of Cellular Response To Stress
Cellular Component Assembly
PML Body
Cytoplasm
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Protein Localization To Nucleus
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Tagcloud (Intersection)
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