KRAS and RBPMS

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KRAS	RBPMS
Description		KRAS proto-oncogene, GTPase	RNA binding protein, mRNA processing factor
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Side Of Plasma Membrane Endomembrane System Membrane	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GMP Binding GDP Binding LRR Domain Binding Identical Protein Binding Protein-membrane Adaptor Activity Protein-containing Complex Binding	Nucleic Acid Binding Transcription Coactivator Activity RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Pre-mRNA Binding Identical Protein Binding Protein Homodimerization Activity Molecular Adaptor Activity Pre-mRNA Intronic Binding MRNA CDS Binding
	Biological Process	MAPK Cascade Liver Development Signal Transduction Ras Protein Signal Transduction Female Pregnancy Cell Population Proliferation Visual Learning Response To Gravity Gene Expression Positive Regulation Of Gene Expression Glial Cell Proliferation Rac Protein Signal Transduction Cytokine-mediated Signaling Pathway Forebrain Astrocyte Development Actin Cytoskeleton Organization Negative Regulation Of Epithelial Cell Differentiation Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Rac Protein Signal Transduction Response To Isolation Stress Skeletal Muscle Cell Differentiation Negative Regulation Of Neuron Apoptotic Process Regulation Of Long-term Neuronal Synaptic Plasticity Homeostasis Of Number Of Cells Within A Tissue Striated Muscle Cell Differentiation Response To Glucocorticoid Response To Mineralocorticoid Neuron Apoptotic Process Myoblast Proliferation Cardiac Muscle Cell Proliferation Positive Regulation Of Glial Cell Proliferation Epithelial Tube Branching Involved In Lung Morphogenesis Type I Pneumocyte Differentiation Positive Regulation Of Cellular Senescence	Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Processing Response To Oxidative Stress Positive Regulation Of DNA-templated Transcription SMAD Protein Signal Transduction Protein-containing Complex Assembly
Pathways		Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF RUNX3 regulates p14-ARF RAS processing Signaling downstream of RAS mutants Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells Signaling by RAS GAP mutants Signaling by RAS GTPase mutants
Drugs		[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Farnesyl diphosphate Adagrasib Sotorasib
Diseases		Acute myeloid leukemia (AML) Oral cancer Non-small cell lung cancer Multiple myeloma Cervical cancer Kaposi's sarcoma Cholangiocarcinoma Gallbladder cancer Gastric cancer Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS) Ovarian cancer Hepatocellular carcinoma Thyroid cancer Squamous cell carcinoma Colorectal cancer Endometrial Cancer Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome Pancreatic cancer
GWAS		Alanine aminotransferase levels ( 33547301) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Dysmenorrheic pain ( 27454463) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)	Blood urea nitrogen levels ( 31152163) Breast size ( 27182965) Eosinophil count ( 32888494) Granulocyte count ( 27863252) Heart rate variability traits ( 22174390) Lymphocyte percentage of white cells ( 27863252 32888494) Mean corpuscular hemoglobin ( 27863252 32888494 28017375) Mean corpuscular volume ( 29403010 32888494 28017375 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) PR interval ( 32439900) Serum alkaline phosphatase levels ( 33547301) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 30224653) Total grey matter volume ( 31530798) White blood cell count ( 32888494)
Interacting Genes		63 interacting genes: ADH6 ARL6IP5 BCAS3 BCL2 CALM1 CCL5 CCT7 CDK8 DDX47 DDX50 DIRAS3 DNAJA3 EGLN1 EPB42 FANCC FNTA FNTB FRAT2 HEMGN HNRNPC HRAS IGFBP3 IGSF21 IL24 LPAR1 LYPD4 LZTR1 MDFI MOCS2 MT-CO3 MT-CYB NDUFA13 NEDD4 OSGIN1 PDE4DIP PGGT1B PIK3CA PIK3CG PIK3R2 PIP5K1A PPP2CB PSMA3 QDPR RAF1 RALGDS RAP1GDS1 RASGRF2 RASGRP2 RASSF2 RASSF5 RBPMS RGL2 RNF141 SERPINB5 SHOC2 SOX4 STX17 THRSP TNFSF13 UQCRC1 WDR76 ZDHHC17 ZNF189	311 interacting genes: ABCF3 ACTMAP ADAM15 ALG13 AMMECR1 ANAPC11 ANKHD1 ANKMY1 APLN ARHGAP9 ARHGEF39 ARID5A ATN1 ATP6V0D1 ATP6V0E2 ATXN1 ATXN7L2 BAG4 BANP BBS2 BCAS2 BCL6B BHLHE40 BOLL C10orf55 C11orf87 C1orf94 C22orf39 CAMK2A CAMK2B CCDC120 CCER1 CCL14 CCNG1 CCNK CDC23 CDC42EP1 CDK6 CEP55 CHCHD7 CIMIP1 CIMIP2B CLPP CNNM3 COL8A1 CPEB2 CPSF7 CRBN CREB5 CRX CRYBA1 CSN3 CSNK1G2-AS1 CYBA DAZAP2 DCAF8 DCDC2B DCTN5 DDX28 DMRT3 DMRTB1 DNTTIP2 DOK3 DOK6 DPYSL4 DTX2 DVL2 DYNC1I1 EAF2 EFEMP2 ENKD1 EWSR1 EXOSC1 EXOSC7 EYA2 FAM120A FAM124B FAM168A FASTK FBF1 FBXL18 FNDC11 FOXC2 FOXP3 FOXS1 FRG1 FXR2 GATA1 GATA2 GATAD2B GCM2 GLIS2 GLYCTK GPATCH2L GPS2 GRAP GRAP2 GSE1 HCK HEY2 HEYL HIVEP1 HNRNPLL HOXA1 HOXA9 HOXB9 HOXC8 HSFY1 IGF2 ILF3 INCA1 INIP IP6K2 KAT5 KCTD9 KIF1A KIR2DL4 KLHDC7B KPNA2 KRAS KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-4 KRTAP13-1 KRTAP13-3 KRTAP15-1 KRTAP19-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP23-1 KRTAP26-1 KRTAP3-1 KRTAP8-1 LARP4B LASP1 LGALS9C LINC00482 LINC00588 LINC00908 LINC01547 LINC01588 LMO4 LONRF1 LRRC41 LZTS2 MAGED1 MAZ MBNL1 MBNL2 MCM5 MCM7 MEIS2 MGAT5B MKRN3 MLLT10 MORN3 MRPL10 MRPL20-AS1 MRPL44 MSI2 MSX1 MVP MYH7B MYO1C MYOZ2 NAB2 NANOG NAPRT NEDD9 NEU4 NIP7 NKX2-5 NR1D2 NTAQ1 NXF1 NYNRIN OTX1 PATL1 PATZ1 PCBP2 PDLIM4 PER1 PGLS PHF1 PICALM PIH1D1 PIN1 PITX1 PITX2 PKP2 PLAC8 PLSCR4 POGZ POLDIP3 POLR3GL POM121 POU4F2 POU6F2 PPP1R16B PRKAA1 PRKAA2 PRKAB2 PRKRA PRPF6 PRR20A PRR20B PRR20C PRR20D PRR20E PRR35 PRRC2B PSG11 PSMF1 PTBP3 QKI R3HDM2 RABL6 RAD54L2 RAMAC RBFOX1 RBFOX2 RBM22 RBM24 RBM42 RBM46 RBM7 RBPMS2 RDH12 RDX RHOBTB3 RHOXF2 RIPPLY1 RNF20 ROR2 RPP25 RPS27A RTP5 RUSC1 SBF2 SEMA4G SERF2 SF1 SFI1 SH3RF2 SIRPB1 SLAIN1 SLC25A48 SLIRP SMAD3 SMAP1 SMARCC2 SMUG1 SNHG29 SNRPB SNRPC SNRPG SNRPN SNW1 SPATA46 SPATA8 SPG7 SPMIP6 SPMIP9 STRBP TBX6 TCEA2 TCF7L2 TEKT5 TENT2 TFG TIE1 TINAGL1 TLE5 TMEM277P TMEM42 TMSB4X TNS2 TOLLIP TOR1AIP2 TRAF4 TRIP13 TSC1 TSG101 TSGA10IP TSPYL6 TTLL10 TUSC2 TXNL4A UBAP2 UNKL VENTX VEZF1 VGLL3 VHL VHLL VPS37C WBP4 WDR54 WDR90 YPEL3 YTHDF1 ZBTB32 ZC3H10 ZIC1 ZMAT5 ZNF34 ZNF385C ZNF488 ZNF581
Entrez ID		3845	11030
HPRD ID		01817	11870
Ensembl ID		ENSG00000133703	ENSG00000157110
Uniprot IDs		I1SRC5 L7RSL8 P01116	B4E3T4 Q93062
PDB IDs		1D8D 1D8E 1KZO 1KZP 1N4P 1N4Q 1N4R 1N4S 2MSC 2MSD 2MSE 3GFT 4DSN 4DSO 4EPR 4EPT 4EPV 4EPW 4EPX 4EPY 4L8G 4LDJ 4LPK 4LRW 4LUC 4LV6 4LYF 4LYH 4LYJ 4M1O 4M1S 4M1T 4M1W 4M1Y 4M21 4M22 4NMM 4OBE 4PZY 4PZZ 4Q01 4Q02 4Q03 4QL3 4TQ9 4TQA 4WA7 5F2E 5KYK 5MLA 5MLB 5O2S 5O2T 5OCG 5OCO 5OCT 5TAR 5TB5 5UFE 5UFQ 5UK9 5UQW 5US4 5USJ 5V6S 5V6V 5V71 5V9L 5V9O 5V9U 5VBM 5VP7 5VPI 5VPY 5VPZ 5VQ0 5VQ1 5VQ2 5VQ6 5VQ8 5W22 5WHA 5WHB 5WHD 5WHE 5WLB 5WPM 5XCO 5YXZ 5YY1 6ARK 6ASA 6ASE 6B0V 6B0Y 6BOF 6BP1 6CC9 6CCH 6CCX 6CU6 6E6F 6E6G 6EPL 6EPM 6EPN 6EPO 6EPP 6F76 6FA1 6FA2 6FA3 6FA4 6GJ5 6GJ6 6GJ7 6GJ8 6GOD 6GOE 6GOF 6GOG 6GOM 6GQT 6GQW 6GQX 6GQY 6H46 6H47 6JTN 6JTO 6JTP 6M9W 6MBQ 6MBT 6MBU 6MNX 6MQG 6MQN 6MS9 6MTA 6N2J 6N2K 6O36 6O46 6O4Y 6O4Z 6O51 6O53 6OB2 6OB3 6OIM 6P0Z 6P8W 6P8X 6P8Y 6P8Z 6PGO 6PGP 6PQ3 6PTS 6PTW 6QUU 6QUV 6QUW 6QUX 6T5B 6T5U 6T5V 6TAM 6TAN 6USX 6USZ 6UT0 6V5L 6V65 6V6F 6VC8 6VJJ 6W4E 6W4F 6WGN 6WS2 6WS4 6XGU 6XGV 6XHA 6XHB 6YR8 6YXW 6ZL5 6ZLI 7A1W 7A1X 7A1Y 7A47 7ACA 7ACF 7ACH 7ACQ 7C40 7C41 7EW9 7EWA 7EWB 7EYX 7F0W 7KFZ 7KMR 7KYZ 7LC1 7LC2 7LGI 7LZ5 7MDP 7MQU 7NY8 7O70 7OK3 7OK4 7OO7 7Q9U 7R0M 7R0N 7R0Q 7ROV 7RP2 7RP3 7RP4 7RPZ 7RSC 7RSE 7RT1 7RT2 7RT3 7RT4 7RT5 7SCW 7SCX 7STF 7T1F 7T47 7TLE 7TLG 7TLK 7U8H 7VVB 7W5R 7YCC 7YCE 7YUZ 7YV1 8AFB 8AFC 8AFD 8AQ5 8AQ7 8AZR 8AZV 8AZX 8AZY 8AZZ 8B00 8B69 8B6I 8B78 8BE3 8BE4 8BE5 8BLR 8CPR 8CX5 8DGS 8DGT 8DNI 8DNJ 8DNK 8DVG 8EBZ 8ECR 8EDY 8EER 8EIE 8EPW 8EZG 8F0M 8FMI 8FMJ 8FMK 8G42 8G47 8G4F 8G4H 8G9P 8G9Q 8I5C 8I5D 8I5E 8JGD 8JHL 8JJS 8K4T 8K4V 8K50 8ONV 8PI0 8PIY 8QU8 8QUG 8QVU 8QW6 8QW7 8R7W 8R7X 8RNI 8RRO 8S8C 8STM 8STN 8T4V 8T71 8T72 8T73 8T74 8T75 8TBF 8TBH 8TBJ 8TBK 8TBL 8TBM 8TBN 8TVK 8TXE 8TXG 8TXH 8TXJ 8TXK 8TY2 8TY8 8TY9 8UDR 8UN3 8UN4 8UN5 8V39 8V3A 8VGQ 8VJZ 8VR9 8VRA 8VRB 8WTE 8WUL 8X6R 8YIV 8YJ2 9AX6 9BFW 9BFY 9BFZ 9BG1 9BHO 9BHP 9BHQ 9BI1 9BI2 9C15 9E5D 9E5F 9E9H 9E9I 9KPM 9KPN	5CYJ 5DET
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Protein Prenyltransferase Activity Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of MAPK Cascade Protein Prenylation Phosphatidylinositol 3-kinase Complex, Class IA GTPase Regulator Activity Prenyltransferase Activity Acetyltransferase Activator Activity Channel Inhibitor Activity Regulation Of Cell Communication Regulation Of Signaling CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Protein Farnesyltransferase Activity Protein Farnesyltransferase Complex Ras Protein Signal Transduction Signal Transduction Protein Farnesylation Positive Regulation Of Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Programmed Cell Death Protein Geranylgeranyltransferase Activity Phosphatidylinositol 3-kinase Complex, Class IB Cytoplasm Glial Cell Development Adenylate Cyclase Activator Activity Quinol-cytochrome-c Reductase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Apoptotic Process Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Programmed Cell Death Protein Geranylgeranylation Insulin Receptor Signaling Pathway Autophagosome Membrane Docking 1-phosphatidylinositol-4-phosphate 3-kinase Activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Intracellular Glucose Homeostasis Neuromuscular Junction Development Apoptotic Process Phosphatidylinositol 3-kinase Complex Negative Regulation Of Fibroblast Apoptotic Process Protein Phosphatase Binding	Nucleus Protein Binding RNA Binding Nucleic Acid Binding Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Intermediate Filament MRNA Processing Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression MRNA Binding Regulation Of Primary Metabolic Process RNA Processing Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process RNA Splicing Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Splicing Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process MRNA Metabolic Process Negative Regulation Of Biosynthetic Process RNA Metabolic Process MRNA Splicing, Via Spliceosome Chromatin Regulation Of Metabolic Process Spliceosomal Complex Negative Regulation Of Metabolic Process Cytoplasmic Stress Granule RNA Splicing, Via Transesterification Reactions RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process
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