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KRAS and MT-CYB
Number of citations of the paper that reports this interaction (PubMedID
25640309
)
0
Data Source:
BioGRID
(two hybrid)
KRAS
MT-CYB
Description
KRAS proto-oncogene, GTPase
cytochrome b
Image
GO Annotations
Cellular Component
Golgi Membrane
Cytoplasm
Mitochondrial Outer Membrane
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Focal Adhesion
Cytoplasmic Side Of Plasma Membrane
Endomembrane System
Membrane
Mitochondrion
Mitochondrial Inner Membrane
Membrane
Protein-containing Complex
Respiratory Chain Complex III
Molecular Function
Nucleotide Binding
GTPase Activity
G Protein Activity
Protein Binding
GTP Binding
Hydrolase Activity
GMP Binding
GDP Binding
LRR Domain Binding
Identical Protein Binding
Protein-membrane Adaptor Activity
Protein-containing Complex Binding
Quinol-cytochrome-c Reductase Activity
Electron Transfer Activity
Oxidoreductase Activity
Protein-containing Complex Binding
Metal Ion Binding
Biological Process
MAPK Cascade
Liver Development
Signal Transduction
Ras Protein Signal Transduction
Female Pregnancy
Cell Population Proliferation
Visual Learning
Response To Gravity
Gene Expression
Positive Regulation Of Gene Expression
Glial Cell Proliferation
Rac Protein Signal Transduction
Cytokine-mediated Signaling Pathway
Forebrain Astrocyte Development
Actin Cytoskeleton Organization
Negative Regulation Of Epithelial Cell Differentiation
Regulation Of Synaptic Transmission, GABAergic
Positive Regulation Of Rac Protein Signal Transduction
Response To Isolation Stress
Skeletal Muscle Cell Differentiation
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Long-term Neuronal Synaptic Plasticity
Homeostasis Of Number Of Cells Within A Tissue
Striated Muscle Cell Differentiation
Response To Glucocorticoid
Response To Mineralocorticoid
Neuron Apoptotic Process
Myoblast Proliferation
Cardiac Muscle Cell Proliferation
Positive Regulation Of Glial Cell Proliferation
Epithelial Tube Branching Involved In Lung Morphogenesis
Type I Pneumocyte Differentiation
Positive Regulation Of Cellular Senescence
Response To Hypoxia
Mitochondrial Electron Transport, Ubiquinol To Cytochrome C
Response To Nutrient
Response To Xenobiotic Stimulus
Response To Toxic Substance
Response To Hormone
Electron Transport Coupled Proton Transport
Respiratory Electron Transport Chain
Animal Organ Regeneration
Response To Cobalamin
Response To Glucagon
Cellular Respiration
Response To Ethanol
Response To Cadmium Ion
Response To Copper Ion
Response To Mercury Ion
Response To Calcium Ion
Response To Hyperoxia
Response To D-galactosamine
Pathways
Signaling by moderate kinase activity BRAF mutants
Paradoxical activation of RAF signaling by kinase inactive BRAF
RUNX3 regulates p14-ARF
RAS processing
Signaling downstream of RAS mutants
Signaling by CSF3 (G-CSF)
Signaling by CSF1 (M-CSF) in myeloid cells
Signaling by RAS GAP mutants
Signaling by RAS GTPase mutants
Mitochondrial translation termination
Respiratory electron transport
Complex III assembly
Complex III assembly
Drugs
[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID
Farnesyl diphosphate
Adagrasib
Sotorasib
2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol
6-Hydroxy-5-undecyl-4,7-benzothiazoledione
Azoxystrobin
5-Heptyl-6-hydroxy-1,3-benzothiazole-4,7-dione
(5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE
(S)-famoxadone
METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
2-Nonyl-4-quinolinol 1-oxide
Ubiquinone Q2
Diseases
Acute myeloid leukemia (AML)
Oral cancer
Non-small cell lung cancer
Multiple myeloma
Cervical cancer
Kaposi's sarcoma
Cholangiocarcinoma
Gallbladder cancer
Gastric cancer
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
Ovarian cancer
Hepatocellular carcinoma
Thyroid cancer
Squamous cell carcinoma
Colorectal cancer
Endometrial Cancer
Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
Pancreatic cancer
Leber optic atrophy; Leber hereditary optic atrophy (LHON)
GWAS
Alanine aminotransferase levels (
33547301
)
Disease progression in age-related macular degeneration (adjusted for baseline) (
29346644
)
Dysmenorrheic pain (
27454463
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Interacting Genes
63 interacting genes:
ADH6
ARL6IP5
BCAS3
BCL2
CALM1
CCL5
CCT7
CDK8
DDX47
DDX50
DIRAS3
DNAJA3
EGLN1
EPB42
FANCC
FNTA
FNTB
FRAT2
HEMGN
HNRNPC
HRAS
IGFBP3
IGSF21
IL24
LPAR1
LYPD4
LZTR1
MDFI
MOCS2
MT-CO3
MT-CYB
NDUFA13
NEDD4
OSGIN1
PDE4DIP
PGGT1B
PIK3CA
PIK3CG
PIK3R2
PIP5K1A
PPP2CB
PSMA3
QDPR
RAF1
RALGDS
RAP1GDS1
RASGRF2
RASGRP2
RASSF2
RASSF5
RBPMS
RGL2
RNF141
SERPINB5
SHOC2
SOX4
STX17
THRSP
TNFSF13
UQCRC1
WDR76
ZDHHC17
ZNF189
2 interacting genes:
KRAS
MVP
Entrez ID
3845
4519
HPRD ID
01817
02468
Ensembl ID
ENSG00000133703
ENSG00000198727
Uniprot IDs
I1SRC5
L7RSL8
P01116
P00156
Q0ZFD6
PDB IDs
1D8D
1D8E
1KZO
1KZP
1N4P
1N4Q
1N4R
1N4S
2MSC
2MSD
2MSE
3GFT
4DSN
4DSO
4EPR
4EPT
4EPV
4EPW
4EPX
4EPY
4L8G
4LDJ
4LPK
4LRW
4LUC
4LV6
4LYF
4LYH
4LYJ
4M1O
4M1S
4M1T
4M1W
4M1Y
4M21
4M22
4NMM
4OBE
4PZY
4PZZ
4Q01
4Q02
4Q03
4QL3
4TQ9
4TQA
4WA7
5F2E
5KYK
5MLA
5MLB
5O2S
5O2T
5OCG
5OCO
5OCT
5TAR
5TB5
5UFE
5UFQ
5UK9
5UQW
5US4
5USJ
5V6S
5V6V
5V71
5V9L
5V9O
5V9U
5VBM
5VP7
5VPI
5VPY
5VPZ
5VQ0
5VQ1
5VQ2
5VQ6
5VQ8
5W22
5WHA
5WHB
5WHD
5WHE
5WLB
5WPM
5XCO
5YXZ
5YY1
6ARK
6ASA
6ASE
6B0V
6B0Y
6BOF
6BP1
6CC9
6CCH
6CCX
6CU6
6E6F
6E6G
6EPL
6EPM
6EPN
6EPO
6EPP
6F76
6FA1
6FA2
6FA3
6FA4
6GJ5
6GJ6
6GJ7
6GJ8
6GOD
6GOE
6GOF
6GOG
6GOM
6GQT
6GQW
6GQX
6GQY
6H46
6H47
6JTN
6JTO
6JTP
6M9W
6MBQ
6MBT
6MBU
6MNX
6MQG
6MQN
6MS9
6MTA
6N2J
6N2K
6O36
6O46
6O4Y
6O4Z
6O51
6O53
6OB2
6OB3
6OIM
6P0Z
6P8W
6P8X
6P8Y
6P8Z
6PGO
6PGP
6PQ3
6PTS
6PTW
6QUU
6QUV
6QUW
6QUX
6T5B
6T5U
6T5V
6TAM
6TAN
6USX
6USZ
6UT0
6V5L
6V65
6V6F
6VC8
6VJJ
6W4E
6W4F
6WGN
6WS2
6WS4
6XGU
6XGV
6XHA
6XHB
6YR8
6YXW
6ZL5
6ZLI
7A1W
7A1X
7A1Y
7A47
7ACA
7ACF
7ACH
7ACQ
7C40
7C41
7EW9
7EWA
7EWB
7EYX
7F0W
7KFZ
7KMR
7KYZ
7LC1
7LC2
7LGI
7LZ5
7MDP
7MQU
7NY8
7O70
7OK3
7OK4
7OO7
7Q9U
7R0M
7R0N
7R0Q
7ROV
7RP2
7RP3
7RP4
7RPZ
7RSC
7RSE
7RT1
7RT2
7RT3
7RT4
7RT5
7SCW
7SCX
7STF
7T1F
7T47
7TLE
7TLG
7TLK
7U8H
7VVB
7W5R
7YCC
7YCE
7YUZ
7YV1
8AFB
8AFC
8AFD
8AQ5
8AQ7
8AZR
8AZV
8AZX
8AZY
8AZZ
8B00
8B69
8B6I
8B78
8BE3
8BE4
8BE5
8BLR
8CPR
8CX5
8DGS
8DGT
8DNI
8DNJ
8DNK
8DVG
8EBZ
8ECR
8EDY
8EER
8EIE
8EPW
8EZG
8F0M
8FMI
8FMJ
8FMK
8G42
8G47
8G4F
8G4H
8G9P
8G9Q
8I5C
8I5D
8I5E
8JGD
8JHL
8JJS
8K4T
8K4V
8K50
8ONV
8PI0
8PIY
8QU8
8QUG
8QVU
8QW6
8QW7
8R7W
8R7X
8RNI
8RRO
8S8C
8STM
8STN
8T4V
8T71
8T72
8T73
8T74
8T75
8TBF
8TBH
8TBJ
8TBK
8TBL
8TBM
8TBN
8TVK
8TXE
8TXG
8TXH
8TXJ
8TXK
8TY2
8TY8
8TY9
8UDR
8UN3
8UN4
8UN5
8V39
8V3A
8VGQ
8VJZ
8VR9
8VRA
8VRB
8WTE
8WUL
8X6R
8YIV
8YJ2
9AX6
9BFW
9BFY
9BFZ
9BG1
9BHO
9BHP
9BHQ
9BI1
9BI2
9C15
9E5D
9E5F
9E9H
9E9I
9KPM
9KPN
5XTE
5XTH
5XTI
Enriched GO Terms of Interacting Partners
?
Regulation Of Intracellular Signal Transduction
Intracellular Signaling Cassette
Protein Prenyltransferase Activity
Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of MAPK Cascade
Protein Prenylation
Phosphatidylinositol 3-kinase Complex, Class IA
GTPase Regulator Activity
Prenyltransferase Activity
Acetyltransferase Activator Activity
Channel Inhibitor Activity
Regulation Of Cell Communication
Regulation Of Signaling
CAAX-protein Geranylgeranyltransferase Activity
CAAX-protein Geranylgeranyltransferase Complex
Protein Farnesyltransferase Activity
Protein Farnesyltransferase Complex
Ras Protein Signal Transduction
Signal Transduction
Protein Farnesylation
Positive Regulation Of Intracellular Signal Transduction
Small GTPase-mediated Signal Transduction
Regulation Of Programmed Cell Death
Protein Geranylgeranyltransferase Activity
Phosphatidylinositol 3-kinase Complex, Class IB
Cytoplasm
Glial Cell Development
Adenylate Cyclase Activator Activity
Quinol-cytochrome-c Reductase Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of Apoptotic Process
Regulation Of Smooth Muscle Cell Migration
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Programmed Cell Death
Protein Geranylgeranylation
Insulin Receptor Signaling Pathway
Autophagosome Membrane Docking
1-phosphatidylinositol-4-phosphate 3-kinase Activity
1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
Intracellular Glucose Homeostasis
Neuromuscular Junction Development
Apoptotic Process
Phosphatidylinositol 3-kinase Complex
Negative Regulation Of Fibroblast Apoptotic Process
Protein Phosphatase Binding
Response To Isolation Stress
GMP Binding
Forebrain Astrocyte Development
Negative Regulation Of Protein Autophosphorylation
LRR Domain Binding
Cardiac Muscle Cell Proliferation
Lung Epithelial Cell Differentiation
Positive Regulation Of Cellular Senescence
Rac Protein Signal Transduction
Myoblast Proliferation
Type I Pneumocyte Differentiation
Positive Regulation Of Rac Protein Signal Transduction
Positive Regulation Of Glial Cell Proliferation
Response To Gravity
Astrocyte Development
Glial Cell Proliferation
Lung Cell Differentiation
Epithelial Tube Branching Involved In Lung Morphogenesis
Cell Population Proliferation
Regulation Of Long-term Neuronal Synaptic Plasticity
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
Protein Activation Cascade
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Protein Tyrosine Kinase Activity
Regulation Of Protein Tyrosine Kinase Activity
Regulation Of Protein Autophosphorylation
Regulation Of Synaptic Transmission, GABAergic
Regulation Of Rac Protein Signal Transduction
Protein-membrane Adaptor Activity
Negative Regulation Of ERBB Signaling Pathway
Response To Mineralocorticoid
Homeostasis Of Number Of Cells Within A Tissue
Regulation Of Glial Cell Proliferation
Muscle Cell Proliferation
Regulation Of Cellular Senescence
Negative Regulation Of Epithelial Cell Differentiation
Visual Learning
Visual Behavior
Regulation Of Neuronal Synaptic Plasticity
GDP Binding
Positive Regulation Of Gliogenesis
G Protein Activity
Skeletal Muscle Cell Differentiation
Glial Cell Development
Striated Muscle Cell Differentiation
Female Pregnancy
Positive Regulation Of Small GTPase Mediated Signal Transduction
Ras Protein Signal Transduction
Negative Regulation Of Kinase Activity
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
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