VPS39 and HOOK1

Number of citations of the paper that reports this interaction (PubMedID 18799622)
36

Data Source:
HPRD (in vivo)

		VPS39	HOOK1
Description		VPS39 subunit of HOPS complex	hook microtubule tethering protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Endosome Membrane Endomembrane System Membrane AP-3 Adaptor Complex HOPS Complex Late Endosome Membrane Lysosomal HOPS Complex	Cytoplasm Centrosome Cytoskeleton Microtubule Microtubule Cytoskeleton HOPS Complex FHF Complex
	Molecular Function	Protein Binding	Actin Binding Protein Binding Microtubule Binding Identical Protein Binding Protein Homodimerization Activity Dynein Light Intermediate Chain Binding
	Biological Process	Intracellular Protein Transport Autophagy Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Endocytic Recycling Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Autophagosome-lysosome Fusion Late Endosome To Lysosome Transport	Golgi Organization Endosome Organization Lysosome Organization Spermatogenesis Spermatid Development Endosome To Lysosome Transport Protein Transport Cell Differentiation Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport Manchette Assembly Protein Localization To Perinuclear Region Of Cytoplasm
Pathways		SARS-CoV-2 modulates autophagy
Drugs
Diseases
GWAS			Alcoholic chronic pancreatitis ( 28754779) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		7 interacting genes: HOOK1 MECOM RILP RUNX1 SNW1 STAT3 TFIP11	46 interacting genes: AKTIP ANK3 ANKRD23 AP1M1 AP4M1 CCDC9 CDC5L CDK4 CUL1 CWF19L2 DENND1B ESS2 EXOSC7 FAM161A FHIP1B HNRNPLL HOOK2 HOOK3 KAT5 LENG1 LMO2 MEOX2 PIAS2 PRPF6 RBM22 RNF10 RPS7 SNW1 TBC1D7 TFIP11 UNKL USP2 UTP14A UTP14C VPS16 VPS18 VPS39 VPS41 ZBTB47 ZNF250 ZNF35 ZNF572 ZNF655 ZNF764 ZNF785 ZNF80
Entrez ID		23339	51361
HPRD ID		10300	07428
Ensembl ID		ENSG00000166887	ENSG00000134709
Uniprot IDs		Q96JC1	Q9UJC3
PDB IDs		6ZE9
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Extracellular Matrix Organization Hematopoietic Stem Cell Proliferation Nuclear Speck Early Endosome To Late Endosome Transport Dynein Light Intermediate Chain Binding Negative Regulation Of DNA-templated Transcription Protein Homodimerization Activity Negative Regulation Of RNA Biosynthetic Process Endosome To Lysosome Transport Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Extracellular Matrix Organization Negative Regulation Of Biosynthetic Process Core-binding Factor Complex Negative Regulation Of Transcription By RNA Polymerase II Stem Cell Proliferation Positive Regulation Of Myeloid Cell Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Pericentric Heterochromatin Organization CENP-A Recruiting Complex Catalytic Step 2 Spliceosome Spliceosomal Complex Disassembly U2-type Post-mRNA Release Spliceosomal Complex Endosome Organization Intralumenal Vesicle Formation Cardiac Muscle Tissue Regeneration Nucleoplasm RNA Sequestering Activity Maintenance Of Cell Number Stem Cell Population Maintenance Lysosomal Transport Positive Regulation Of Vasculature Development Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Angiogenesis Regulation Of Macromolecule Metabolic Process Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation DNA-binding Transcription Factor Binding DNA Binding Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Regulation Of Metabolic Process Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Histone H3K9me2 Methyltransferase Activity	HOPS Complex Endosome To Lysosome Transport Vacuolar Transport Lysosomal Transport FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Lysosome Organization Vacuole Organization Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Catalytic Step 2 Spliceosome Vesicle Organization Early Endosome To Late Endosome Transport MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Clathrin-coated Vesicle AP-3 Adaptor Complex Endosome Organization RNA Processing Regulation Of Transcription By RNA Polymerase II Lysosomal HOPS Complex Protein Transport Endosomal Transport Spliceosomal Complex MRNA Processing Establishment Of Protein Localization MRNA Metabolic Process Zinc Ion Binding RNA Splicing U2-type Catalytic Step 2 Spliceosome Vesicle-mediated Transport Nucleus Intracellular Transport Regulation Of Macromolecule Metabolic Process RNA Metabolic Process CORVET Complex Regulation Of Gene Expression Vesicle Fusion Regulation Of Metabolic Process Nuclear Speck Organelle Membrane Fusion Regulation Of DNA-templated Transcription Positive Regulation Of RNA Splicing Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Cellular Localization Regulation Of Primary Metabolic Process Nucleic Acid Metabolic Process Protein Targeting To Vacuole Clathrin Adaptor Complex
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