VPS39 and RILP

Number of citations of the paper that reports this interaction (PubMedID 25445562)
46

Data Source:
BioGRID (pull down)

		VPS39	RILP
Description		VPS39 subunit of HOPS complex	Rab interacting lysosomal protein
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Endosome Membrane Endomembrane System Membrane AP-3 Adaptor Complex HOPS Complex Late Endosome Membrane Lysosomal HOPS Complex	Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Protein-containing Complex Ciliary Basal Body
	Molecular Function	Protein Binding	Protein Binding Small GTPase Binding Protein Dimerization Activity Dynein Light Intermediate Chain Binding
	Biological Process	Intracellular Protein Transport Autophagy Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Endocytic Recycling Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Autophagosome-lysosome Fusion Late Endosome To Lysosome Transport	Endosome To Lysosome Transport Protein Transport Endosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Protein Catabolic Process Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Cilium Assembly Intralumenal Vesicle Formation
Pathways		SARS-CoV-2 modulates autophagy	MHC class II antigen presentation
Drugs
Diseases
GWAS
Interacting Genes		7 interacting genes: HOOK1 MECOM RILP RUNX1 SNW1 STAT3 TFIP11	12 interacting genes: KPNA2 LDB2 RAB34 RAB7A RCHY1 SNF8 VPS11 VPS16 VPS18 VPS36 VPS39 VPS41
Entrez ID		23339	83547
HPRD ID		10300	09706
Ensembl ID		ENSG00000166887	ENSG00000167705
Uniprot IDs		Q96JC1	Q96NA2
PDB IDs		6ZE9	1YHN
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Extracellular Matrix Organization Hematopoietic Stem Cell Proliferation Nuclear Speck Early Endosome To Late Endosome Transport Dynein Light Intermediate Chain Binding Negative Regulation Of DNA-templated Transcription Protein Homodimerization Activity Negative Regulation Of RNA Biosynthetic Process Endosome To Lysosome Transport Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Extracellular Matrix Organization Negative Regulation Of Biosynthetic Process Core-binding Factor Complex Negative Regulation Of Transcription By RNA Polymerase II Stem Cell Proliferation Positive Regulation Of Myeloid Cell Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Pericentric Heterochromatin Organization CENP-A Recruiting Complex Catalytic Step 2 Spliceosome Spliceosomal Complex Disassembly U2-type Post-mRNA Release Spliceosomal Complex Endosome Organization Intralumenal Vesicle Formation Cardiac Muscle Tissue Regeneration Nucleoplasm RNA Sequestering Activity Maintenance Of Cell Number Stem Cell Population Maintenance Lysosomal Transport Positive Regulation Of Vasculature Development Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Angiogenesis Regulation Of Macromolecule Metabolic Process Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation DNA-binding Transcription Factor Binding DNA Binding Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Regulation Of Metabolic Process Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Histone H3K9me2 Methyltransferase Activity	Vesicle Organization Late Endosome Membrane Vacuolar Transport Organelle Membrane Fusion Vesicle Fusion Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion HOPS Complex Endosome To Lysosome Transport Organelle Fusion Autophagy Late Endosome Membrane Fusion Intracellular Protein Transport Membrane Organization Protein Transport Lysosomal Transport Endosome Membrane Establishment Of Protein Localization Cellular Localization Vesicle-mediated Transport Endosome Intracellular Transport Intracellular Protein Localization Lysosome CORVET Complex AP-3 Adaptor Complex Establishment Of Localization In Cell Establishment Of Protein Localization To Vacuole Lysosomal Membrane Clathrin-coated Vesicle Organelle Organization Endosome Organization Protein Localization To Vacuole Catabolic Process Lysosomal HOPS Complex Endosomal Transport ESCRT II Complex Vesicle-mediated Transport To The Plasma Membrane Establishment Of Protein Localization To Organelle Vesicle Tethering Complex Macroautophagy Vacuole Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Catabolic Process Cytoplasmic Vesicle Endocytic Recycling Autophagosome Phagosome Maturation Membrane Docking
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