FMR1 and CALCOCO2

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		FMR1	CALCOCO2
Description		fragile X messenger ribonucleoprotein 1	calcium binding and coiled-coil domain 2
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Plasma Membrane Chromocenter Cytoplasmic Stress Granule Postsynaptic Density Cajal Body Membrane Axon Dendrite Growth Cone Filopodium Tip SMN Complex Cytoplasmic Ribonucleoprotein Granule Presynaptic Membrane Cell Projection Neuron Projection Dendritic Spine Perikaryon Intracellular Membraneless Organelle Axon Terminus Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Neuronal Ribonucleoprotein Granule Glial Cell Projection Presynapse Postsynapse Dendritic Filopodium Growth Cone Filopodium Ribonucleoprotein Complex	Autophagosome Membrane Nucleus Cytoplasm Autophagosome Cytosol Cytoskeleton Membrane PML Body Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	G-quadruplex RNA Binding Nucleic Acid Binding Chromatin Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Microtubule Binding Poly(U) RNA Binding Translation Repressor Activity Translation Initiation Factor Binding RNA Strand Annealing Activity Poly(G) Binding SiRNA Binding MiRNA Binding Signaling Adaptor Activity RNA Stem-loop Binding Identical Protein Binding Protein Homodimerization Activity Ribosome Binding Transmembrane Transporter Binding Protein-containing Complex Binding Translation Regulator Activity Protein Heterodimerization Activity MRNA 5'-UTR Binding Dynein Complex Binding Histone H3 Reader Activity Molecular Condensate Scaffold Activity N6-methyladenosine-containing RNA Reader Activity Sequence-specific MRNA Binding	Protein Binding Zinc Ion Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Receptor Internalization DNA Repair Chromatin Organization MRNA Processing MRNA Export From Nucleus Regulation Of Translation DNA Damage Response Glutamate Receptor Signaling Pathway Nervous System Development RNA Splicing Regulation Of Cell Communication Negative Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing Stress Granule Assembly Regulation Of MRNA Stability Host-mediated Perturbation Of Viral RNA Genome Replication Positive Regulation Of Translation Negative Regulation Of Translational Initiation Regulation Of Neurotransmitter Secretion Positive Regulation Of Long-term Neuronal Synaptic Plasticity Animal Organ Development MRNA Transport Positive Regulation Of Cellular Component Organization Regulation Of Filopodium Assembly Positive Regulation Of Filopodium Assembly Negative Regulation Of MiRNA-mediated Gene Silencing Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Development Regulation Of Biological Quality Cellular Response To Virus Regulation Of Neuronal Action Potential Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Membraneless Organelle Assembly Negative Regulation Of Long-term Synaptic Depression Positive Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Cytoplasmic Translation	Autophagy Viral Process Response To Type II Interferon Xenophagy Positive Regulation Of Autophagosome Maturation
Pathways
Drugs
Diseases		Premature ovarian failure Fragile X Syndrome, including: Fragile X Syndrome (FXS); Fragile X tremor/ataxia syndrome (FXTAS)
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Fragile X syndrome ( 30531935)	Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Chronotype ( 30696823) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301) Type 2 diabetes ( 29358691 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		49 interacting genes: AKAP9 ALDOC ATG5 BEX4 CALCOCO2 CAMK2B CASK CCAR2 CWC25 CYFIP1 CYFIP2 DCTPP1 DGKD EFHC1 FSD2 FXR1 FXR2 GRIP2 H19 HOMER3 INCA1 LIMS1 MAGI3 MEOX1 MVP NCL NECAB2 NUFIP1 NUFIP2 PICK1 POLR1C PPP1R12C PSME3 RANBP9 RBM14 SF3B2 SFPQ SHARPIN SPAG5 STAU1 SUOX TACC2 UBE2I USP7 WEE2-AS1 YBX1 ZBTB42 ZFPM2 ZMYND8	182 interacting genes: ABLIM1 ADSL AMMECR1 AP5B1 APEX2 ARHGEF39 ARHGEF5 ARNT2 ATG5 ATOSB AXIN1 BAHD1 BCL6B CBX8 CCDC120 CCDC185 CCDC33 CCNH CDC7 CELA2B CEP57L1 CHCHD3 CNNM3 CPNE7 CWF19L2 DAXX DAZAP2 DBNDD2 DCTN4 DCX DDIT4L DDX6 DOCK2 DUSP12 DUSP26 EEF1E1 EFHC1 ELOA2 ENKD1 ENTREP1 EXOSC5 FAM107A FAM161A FAM168A FAM90A1 FARS2 FASTK FBF1 FBXL18 FKBPL FMR1 FNDC11 FOXD4L3 FUBP3 FXR2 GABARAPL1 GABARAPL2 GATAD2B GCA GEMIN4 GIT2 GLYCTK HDAC4 HDAC7 HLX HNRNPA1 HNRNPK HNRNPLL HOXB5 HOXB9 IL16 IQUB KANSL1 KAT7 KLHL35 KLHL42 LENG1 LGALS8 LIMS2 LITAF LMF2 LMO2 LMO4 LNX1 LONRF1 LSM4 MAGOHB MAP1LC3C MCM10 METTL17 MID2 MOS MTPAP MVP MXI1 MYH6 MYO6 NAA10 NDN NFU1 ORC5 PCGF1 PEF1 PEG10 PFDN5 PHF1 PIAS4 POLI POLR2A PPP1R18 PRKAA2 PRKAB2 PRPF18 PRPF31 PSMA1 PSME4 PTBP1 PTBP2 RAB35 RABL6 RB1CC1 RBM15 RHPN1 RIN1 RNF11 RPA2 RPL9 RPS27A RTN4IP1 RTP5 RXRB SCAND1 SCNM1 SDCBP SETD5 SHC1 SLC15A3 SMARCD1 SMCP SNRPB SPATA24 SRI STAMBPL1 STK16 TACO1 TBC1D22B TBRG4 TCL1A TEKT3 TENT2 TLE5 TNFAIP3 TP53RK TRAF2 TRAF4 TSC1 TSGA10IP TTC23L UBAC2 UBC ULK1 USP2 VARS1 VPS72 WWP2 ZBTB4 ZC2HC1C ZNF101 ZNF205 ZNF337 ZNF408 ZNF414 ZNF426 ZNF451 ZNF564 ZNF581 ZNF638 ZNF648 ZNF688 ZNF696 ZNF774 ZNF80
Entrez ID		2332	10241
HPRD ID		02398	06846
Ensembl ID		ENSG00000102081	ENSG00000136436
Uniprot IDs		Q06787	Q13137
PDB IDs		2BKD 2FMR 2LA5 2QND 4OVA 4QVZ 4QW2 5DE5 5DE8 5DEA 5UWJ 5UWO	2MXP 3VVV 3VVW 4GXL 4HAN 4XKL 5AAQ 5Z7A 5Z7L 7EAA
Enriched GO Terms of Interacting Partners?		Cytoplasm Modulation Of Chemical Synaptic Transmission Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Metabolic Process Cytosol Negative Regulation Of Protein Metabolic Process Cytoplasmic Stress Granule Synapse Negative Regulation Of Macromolecule Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Perinuclear Region Of Cytoplasm Negative Regulation Of Metabolic Process Neuron Projection Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cellular Component Organization Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Cytoplasmic Ribonucleoprotein Granule Regulation Of Organelle Organization Negative Regulation Of Biosynthetic Process Cytoskeleton Positive Regulation Of Long-term Neuronal Synaptic Plasticity GMP Kinase Activity Regulation Of Synaptic Plasticity Regulation Of Circadian Rhythm Regulation Of Macromolecule Metabolic Process Dendrite Extension Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Primary Metabolic Process GDP Metabolic Process SCAR Complex Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Deacetylation Microtubule-based Process Regulation Of Signal Transduction Postsynapse Regulation Of Neuronal Synaptic Plasticity Regulation Of Metabolic Process RNA Splicing Positive Regulation Of Organelle Organization Transferase Complex RNA 7-methylguanosine Cap Binding Positive Regulation Of Cellular Component Biogenesis Nuclear Body Nucleoplasm MRNA Binding	Protein Binding Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Zinc Ion Binding Cellular Response To Nitrogen Starvation Ubiquitin Protein Ligase Binding MRNA Processing MRNA Metabolic Process MRNA Binding Regulation Of RNA Splicing Cytoplasm RNA Splicing Negative Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process RNA Metabolic Process Metal Ion Binding Regulation Of Transcription By RNA Polymerase II DNA Binding Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Response To Nutrient Levels RNA Processing Macromolecule Metabolic Process Response To Starvation Autophagy Of Mitochondrion Spliceosomal Complex Epigenetic Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Nuclear Speck Regulation Of MRNA Metabolic Process Autophagosome Autophagosome Membrane Negative Regulation Of Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission SnRNP Binding Mitophagy Negative Regulation Of Nucleobase-containing Compound Metabolic Process Phosphatidylethanolamine Binding Negative Regulation Of Gene Expression Cytoplasmic Stress Granule
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