FMR1 and NUFIP1

Number of citations of the paper that reports this interaction (PubMedID 10556305)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		FMR1	NUFIP1
Description		fragile X messenger ribonucleoprotein 1	nuclear FMR1 interacting protein 1
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Plasma Membrane Chromocenter Cytoplasmic Stress Granule Postsynaptic Density Cajal Body Membrane Axon Dendrite Growth Cone Filopodium Tip SMN Complex Cytoplasmic Ribonucleoprotein Granule Presynaptic Membrane Cell Projection Neuron Projection Dendritic Spine Perikaryon Intracellular Membraneless Organelle Axon Terminus Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Neuronal Ribonucleoprotein Granule Glial Cell Projection Presynapse Postsynapse Dendritic Filopodium Growth Cone Filopodium Ribonucleoprotein Complex	Fibrillar Center Nucleus Nucleoplasm Perichromatin Fibrils Nucleolus Transcription Elongation Factor Complex Nuclear Matrix Protein-containing Complex Synapse Presynaptic Active Zone Pre-snoRNP Complex
	Molecular Function	G-quadruplex RNA Binding Nucleic Acid Binding Chromatin Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Microtubule Binding Poly(U) RNA Binding Translation Repressor Activity Translation Initiation Factor Binding RNA Strand Annealing Activity Poly(G) Binding SiRNA Binding MiRNA Binding Signaling Adaptor Activity RNA Stem-loop Binding Identical Protein Binding Protein Homodimerization Activity Ribosome Binding Transmembrane Transporter Binding Protein-containing Complex Binding Translation Regulator Activity Protein Heterodimerization Activity MRNA 5'-UTR Binding Dynein Complex Binding Histone H3 Reader Activity Molecular Condensate Scaffold Activity N6-methyladenosine-containing RNA Reader Activity Sequence-specific MRNA Binding	DNA Binding RNA Binding Protein Binding Zinc Ion Binding SnoRNA Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Metal Ion Binding ATPase Binding
	Biological Process	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Receptor Internalization DNA Repair Chromatin Organization MRNA Processing MRNA Export From Nucleus Regulation Of Translation DNA Damage Response Glutamate Receptor Signaling Pathway Nervous System Development RNA Splicing Regulation Of Cell Communication Negative Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing Stress Granule Assembly Regulation Of MRNA Stability Host-mediated Perturbation Of Viral RNA Genome Replication Positive Regulation Of Translation Negative Regulation Of Translational Initiation Regulation Of Neurotransmitter Secretion Positive Regulation Of Long-term Neuronal Synaptic Plasticity Animal Organ Development MRNA Transport Positive Regulation Of Cellular Component Organization Regulation Of Filopodium Assembly Positive Regulation Of Filopodium Assembly Negative Regulation Of MiRNA-mediated Gene Silencing Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Development Regulation Of Biological Quality Cellular Response To Virus Regulation Of Neuronal Action Potential Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Membraneless Organelle Assembly Negative Regulation Of Long-term Synaptic Depression Positive Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Cytoplasmic Translation	Box C/D SnoRNP Assembly RNA Processing Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases		Premature ovarian failure Fragile X Syndrome, including: Fragile X Syndrome (FXS); Fragile X tremor/ataxia syndrome (FXTAS)
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Fragile X syndrome ( 30531935)	Body mass index ( 25760438) HDL cholesterol levels ( 32203549) Oleic acid (18:1n-9) levels ( 23362303) Refractive error ( 32231278) Rosacea symptom severity ( 29771307)
Interacting Genes		49 interacting genes: AKAP9 ALDOC ATG5 BEX4 CALCOCO2 CAMK2B CASK CCAR2 CWC25 CYFIP1 CYFIP2 DCTPP1 DGKD EFHC1 FSD2 FXR1 FXR2 GRIP2 H19 HOMER3 INCA1 LIMS1 MAGI3 MEOX1 MVP NCL NECAB2 NUFIP1 NUFIP2 PICK1 POLR1C PPP1R12C PSME3 RANBP9 RBM14 SF3B2 SFPQ SHARPIN SPAG5 STAU1 SUOX TACC2 UBE2I USP7 WEE2-AS1 YBX1 ZBTB42 ZFPM2 ZMYND8	12 interacting genes: BRCA1 CCNT1 DDX20 FMR1 GEMIN2 GEMIN4 GEMIN6 KLF6 OGT SNU13 TAF9 TTC3
Entrez ID		2332	26747
HPRD ID		02398	05073
Ensembl ID		ENSG00000102081	ENSG00000083635
Uniprot IDs		Q06787	Q9UHK0
PDB IDs		2BKD 2FMR 2LA5 2QND 4OVA 4QVZ 4QW2 5DE5 5DE8 5DEA 5UWJ 5UWO	5L85
Enriched GO Terms of Interacting Partners?		Cytoplasm Modulation Of Chemical Synaptic Transmission Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Metabolic Process Cytosol Negative Regulation Of Protein Metabolic Process Cytoplasmic Stress Granule Synapse Negative Regulation Of Macromolecule Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Perinuclear Region Of Cytoplasm Negative Regulation Of Metabolic Process Neuron Projection Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cellular Component Organization Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Cytoplasmic Ribonucleoprotein Granule Regulation Of Organelle Organization Negative Regulation Of Biosynthetic Process Cytoskeleton Positive Regulation Of Long-term Neuronal Synaptic Plasticity GMP Kinase Activity Regulation Of Synaptic Plasticity Regulation Of Circadian Rhythm Regulation Of Macromolecule Metabolic Process Dendrite Extension Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Primary Metabolic Process GDP Metabolic Process SCAR Complex Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Deacetylation Microtubule-based Process Regulation Of Signal Transduction Postsynapse Regulation Of Neuronal Synaptic Plasticity Regulation Of Metabolic Process RNA Splicing Positive Regulation Of Organelle Organization Transferase Complex RNA 7-methylguanosine Cap Binding Positive Regulation Of Cellular Component Biogenesis Nuclear Body Nucleoplasm MRNA Binding	SMN Complex Gemini Of Cajal Bodies SMN-Sm Protein Complex Protein-RNA Complex Assembly Spliceosomal SnRNP Assembly Nucleoplasm MRNA Metabolic Process RNA Splicing MRNA Processing Nucleic Acid Metabolic Process RNA Metabolic Process Nucleolus Nuclear Body Nucleobase-containing Compound Metabolic Process Protein-containing Complex Assembly Nucleus Macromolecule Metabolic Process RNA Processing Protein-containing Complex Organization Box C/D SnoRNP Assembly Cellular Component Assembly RNA Polymerase Binding DNA-binding Transcription Factor Binding Regulation Of Lipid Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process RNA Splicing, Via Transesterification Reactions Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Spliceosomal Complex Assembly Molecular Condensate Scaffold Activity Transcription Cis-regulatory Region Binding Positive Regulation Of Intracellular Transport Of Viral Material Box C/D Sno(s)RNA Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Cajal Body Positive Regulation Of Transcription By RNA Polymerase II P53 Binding Regulation Of Lipid Metabolic Process Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Host-mediated Perturbation Of Viral Process P-TEFb Complex Dendritic Filopodium Histone H3 Reader Activity U4atac SnRNP Dense Fibrillar Component
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