FMR1 and DCTPP1

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		FMR1	DCTPP1
Description		fragile X messenger ribonucleoprotein 1	dCTP pyrophosphatase 1
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Plasma Membrane Chromocenter Cytoplasmic Stress Granule Postsynaptic Density Cajal Body Membrane Axon Dendrite Growth Cone Filopodium Tip SMN Complex Cytoplasmic Ribonucleoprotein Granule Presynaptic Membrane Cell Projection Neuron Projection Dendritic Spine Perikaryon Intracellular Membraneless Organelle Axon Terminus Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Neuronal Ribonucleoprotein Granule Glial Cell Projection Presynapse Postsynapse Dendritic Filopodium Growth Cone Filopodium Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	G-quadruplex RNA Binding Nucleic Acid Binding Chromatin Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Microtubule Binding Poly(U) RNA Binding Translation Repressor Activity Translation Initiation Factor Binding RNA Strand Annealing Activity Poly(G) Binding SiRNA Binding MiRNA Binding Signaling Adaptor Activity RNA Stem-loop Binding Identical Protein Binding Protein Homodimerization Activity Ribosome Binding Transmembrane Transporter Binding Protein-containing Complex Binding Translation Regulator Activity Protein Heterodimerization Activity MRNA 5'-UTR Binding Dynein Complex Binding Histone H3 Reader Activity Molecular Condensate Scaffold Activity N6-methyladenosine-containing RNA Reader Activity Sequence-specific MRNA Binding	Nucleotide Binding Magnesium Ion Binding Protein Binding Pyrophosphatase Activity Hydrolase Activity Pyrimidine Deoxyribonucleotide Binding Identical Protein Binding Metal Ion Binding Nucleoside Triphosphate Diphosphatase Activity DCTP Diphosphatase Activity
	Biological Process	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Receptor Internalization DNA Repair Chromatin Organization MRNA Processing MRNA Export From Nucleus Regulation Of Translation DNA Damage Response Glutamate Receptor Signaling Pathway Nervous System Development RNA Splicing Regulation Of Cell Communication Negative Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing Stress Granule Assembly Regulation Of MRNA Stability Host-mediated Perturbation Of Viral RNA Genome Replication Positive Regulation Of Translation Negative Regulation Of Translational Initiation Regulation Of Neurotransmitter Secretion Positive Regulation Of Long-term Neuronal Synaptic Plasticity Animal Organ Development MRNA Transport Positive Regulation Of Cellular Component Organization Regulation Of Filopodium Assembly Positive Regulation Of Filopodium Assembly Negative Regulation Of MiRNA-mediated Gene Silencing Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Development Regulation Of Biological Quality Cellular Response To Virus Regulation Of Neuronal Action Potential Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Membraneless Organelle Assembly Negative Regulation Of Long-term Synaptic Depression Positive Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Cytoplasmic Translation	DCTP Catabolic Process Nucleoside Triphosphate Catabolic Process DNA Protection DTTP Catabolic Process
Pathways			Interconversion of nucleotide di- and triphosphates
Drugs
Diseases		Premature ovarian failure Fragile X Syndrome, including: Fragile X Syndrome (FXS); Fragile X tremor/ataxia syndrome (FXTAS)
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Fragile X syndrome ( 30531935)	Urinary sodium excretion ( 31409800)
Interacting Genes		49 interacting genes: AKAP9 ALDOC ATG5 BEX4 CALCOCO2 CAMK2B CASK CCAR2 CWC25 CYFIP1 CYFIP2 DCTPP1 DGKD EFHC1 FSD2 FXR1 FXR2 GRIP2 H19 HOMER3 INCA1 LIMS1 MAGI3 MEOX1 MVP NCL NECAB2 NUFIP1 NUFIP2 PICK1 POLR1C PPP1R12C PSME3 RANBP9 RBM14 SF3B2 SFPQ SHARPIN SPAG5 STAU1 SUOX TACC2 UBE2I USP7 WEE2-AS1 YBX1 ZBTB42 ZFPM2 ZMYND8	12 interacting genes: APP FMR1 FXR1 FXR2 LNX1 NIF3L1 NOA1 NTAQ1 PSMA1 SDCBP SPG21 USP7
Entrez ID		2332	79077
HPRD ID		02398	18310
Ensembl ID		ENSG00000102081	ENSG00000179958
Uniprot IDs		Q06787	Q9H773
PDB IDs		2BKD 2FMR 2LA5 2QND 4OVA 4QVZ 4QW2 5DE5 5DE8 5DEA 5UWJ 5UWO	7MU5
Enriched GO Terms of Interacting Partners?		Cytoplasm Modulation Of Chemical Synaptic Transmission Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Metabolic Process Cytosol Negative Regulation Of Protein Metabolic Process Cytoplasmic Stress Granule Synapse Negative Regulation Of Macromolecule Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Perinuclear Region Of Cytoplasm Negative Regulation Of Metabolic Process Neuron Projection Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cellular Component Organization Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Cytoplasmic Ribonucleoprotein Granule Regulation Of Organelle Organization Negative Regulation Of Biosynthetic Process Cytoskeleton Positive Regulation Of Long-term Neuronal Synaptic Plasticity GMP Kinase Activity Regulation Of Synaptic Plasticity Regulation Of Circadian Rhythm Regulation Of Macromolecule Metabolic Process Dendrite Extension Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Primary Metabolic Process GDP Metabolic Process SCAR Complex Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Deacetylation Microtubule-based Process Regulation Of Signal Transduction Postsynapse Regulation Of Neuronal Synaptic Plasticity Regulation Of Metabolic Process RNA Splicing Positive Regulation Of Organelle Organization Transferase Complex RNA 7-methylguanosine Cap Binding Positive Regulation Of Cellular Component Biogenesis Nuclear Body Nucleoplasm MRNA Binding	Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Translation Regulator Activity Growth Cone Filopodium Postsynapse RNA Strand Annealing Activity Presynaptic Modulation Of Chemical Synaptic Transmission Intracellular Membraneless Organelle Protein Heterodimerization Activity Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing Regulation Of Synaptic Plasticity Regulation Of Receptor Internalization Cytoplasmic Ribonucleoprotein Granule Presynapse Collateral Sprouting Cytoplasmic Stress Granule DNA Repair Positive Regulation Of Catabolic Process Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Receptor Internalization MRNA Transport MRNA 3'-UTR Binding Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Dentate Gyrus Development Neuron Maturation Regulation Of Nucleobase-containing Compound Metabolic Process Neuron Projection Frizzled Binding Dendritic Spine RNA Transport Positive Regulation Of Translation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Intracellular Transport Of Viral Material Interleukin-5 Receptor Complex Protein-N-terminal Glutamine Amidohydrolase Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Adrenal Cortex Development Regulation Of Long-term Synaptic Potentiation Chromosome Regulation Of RNA Metabolic Process Regulation Of Translation Molecular Condensate Scaffold Activity
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