ANKS1A and USP7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ANKS1A	USP7
Description		ankyrin repeat and sterile alpha motif domain containing 1A	ubiquitin specific peptidase 7
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cell Projection Neuron Projection	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Body PML Body Protein-containing Complex
	Molecular Function	Protein Binding Ephrin Receptor Binding	P53 Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Deubiquitinase Activity K48-linked Deubiquitinase Activity
	Biological Process	Substrate-dependent Cell Migration Neuron Remodeling Ephrin Receptor Signaling Pathway	Autophagosome Assembly DNA Repair Transcription-coupled Nucleotide-excision Repair DNA Alkylation Repair Proteolysis DNA Damage Response Negative Regulation Of Autophagy Positive Regulation Of Autophagy Protein Ubiquitination Protein Deubiquitination Regulation Of Protein Stability Cellular Response To Nutrient Levels Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Monoubiquitinated Protein Deubiquitination TORC1 Signaling Regulation Of Circadian Rhythm Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Gluconeogenesis Rhythmic Process Protein Stabilization Regulation Of DNA-binding Transcription Factor Activity Regulation Of Establishment Of Protein Localization To Telomere Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of TORC1 Signaling Regulation Of Telomere Capping Regulation Of Retrograde Transport, Endosome To Golgi
Pathways			Ub-specific processing proteases Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Degradation Synthesis of active ubiquitin: roles of E1 and E2 enzymes Regulation of PTEN localization
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Height ( 23563607 28552196 18391951) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean platelet volume ( 32888494) Non-small cell lung cancer ( 23144319) Obesity-related traits ( 23251661) Platelet distribution width ( 32888494) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172) Waist-hip index ( 34021172)	Appendicular lean mass ( 33097823) Chronotype ( 30696823) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494)
Interacting Genes		99 interacting genes: ABI2 ACTMAP ADGRL1 ALDOC ANKRD55 ARAP3 ARHGAP10 BCAR1 BLZF1 C17orf50 C22orf39 C3orf36 C9orf152 CADPS CCDC184 CCDC33 CHCHD3 CREBBP CYSRT1 DOK3 EGFR ERBB2 ERBB4 ESM1 FAM217B FAM221A FAM86C1P FCHSD2 FHL5 GOLGA2 GPRIN2 HOXA1 HOXC8 ID3 IKZF3 ISCA2 ITIH6 KCTD9 KEAP1 KIAA1328 KLF15 KLHL26 KPRP KRT31 KRT34 KRT39 KRT75 KRT83 KRTAP10-11 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP19-7 KRTAP4-2 KRTAP6-2 KRTAP9-3 LASP1 LHX2 LNX1 MBD3L1 MED20 MEOX2 MID2 MTUS2 NADSYN1 NBPF19 NEDD9 NHLRC2 NOTCH2NLA NUTM2F PIK3R3 PRDM6 PRKAR1B RANBP3 RB1 RIN1 RNF144B RORB RUSC1 SCN5A SH3KBP1 SHISA6 SLC15A2 SMARCD1 SORBS3 SPATA12 SPRED1 TOX2 TP53BP1 TRIM29 TRIT1 UBC USP54 USP7 YWHAG ZBTB32 ZBTB42 ZC2HC1C ZNF135	349 interacting genes: ABCB1 ABRAXAS2 ACACB ACD ACLY ADAR ADARB1 AHNAK AKIRIN1 ALB ANKS1A ANXA1 ANXA9 ARHGEF17 ARMC5 ARNT2 ASPM ATXN1 AXIN1 BACH1 BCLAF1 BCOR BEND5 BRPF1 BSN CAMSAP1 CAV1 CBR1 CBX8 CCAR1 CCDC141 CCP110 CDC42BPA CDC5L CDR2L CENPE CEP250 CGNL1 CLSPN CLTC COBLL1 CREB3L3 CRY1 CSNK2A1 CTDP1 CTTN DAXX DBN1 DCD DCTPP1 DDX17 DDX21 DDX24 DDX3X DDX5 DDX50 DDX54 DDX60 DHX15 DHX30 DHX40 DHX9 DLST DMD DNAH5 DNAJA3 DNAJC16 DNHD1 DNMT3A DSP DST DUSP2 DYRK1A ECT2 EEA1 EEF1B2 EEF1D EEF1G EFCAB5 EFTUD2 ERCC6 ETS2 EWSR1 EXOSC10 FAM120C FAM186A FANCD2 FAT2 FAT3 FBXO38 FER1L6 FLG2 FMR1 FOXM1 FOXN2 FXR1 GATA1 GIGYF2 GMPS GNL3 GOLGB1 GON4L GRM1 GRWD1 GTF2I GTPBP4 H2AC20 H2BC26 H2BC3 H3C1 HECW1 HERC1 HERPUD1 HMOX1 HNRNPC HNRNPL HNRNPM HNRNPR HRNR HSPA9 HTRA2 IFNAR1 IGF2BP1 IGF2BP3 IGHG1 IKZF1 ILF3 IPCEF1 KDR KHDRBS1 KIAA1549L KIF13A KLF12 KLHL5 KLHL8 KMT2D KRI1 LAMA1 LEPR LIMA1 LINC02582 LINGO2 LPIN3 LRBA LTF LTV1 LUC7L3 MACF1 MAGEE1 MAL MARCHF7 MAST2 MATR3 MCMBP MDC1 MDM2 MDM4 MDN1 MEX3B MINK1 MLF2 MPRIP MTREX MYBBP1A MYC MYD88 MYH13 MYO1B MYO5A MYO7B NAT10 NEB NECAB2 NEDD4L NGEF NKRF NLRP11 NOM1 NOP2 NSD1 NUMA1 OGDH OTOF OTUD4 OVCH1 PABPC1 PARP1 PBRM1 PC PCARE PCGF2 PCLAF PDE3A PEG3 PELP1 PEPD PES1 PHLDB2 PICK1 PIP PKM PLA2G2A PLCH1 PLEC PLEKHO1 PLK1 PNN PNPLA4 POLI POP1 PPARG PPFIA1 PPIP5K1 PPL PPP1R12A PRDM16 PRPF19 PRPF40A PRPF8 PSIP1 PTEN PWP1 RAD18 RAD50 RADIL RAF1 RAI14 RALY RARA RB1 RBBP4 RBCK1 RBM15 RBM39 RCC2 RELA RFC1 RFFL RGPD8 RNF168 RNF220 RPL7A RPLP0 RPS3 RPS4X RPS6 RSL1D1 RSPH1 SALL1 SAMHD1 SAP130 SAP30BP SCML2 SDK2 SENP1 SERBP1 SF3B1 SF3B2 SF3B3 SHOC2 SIRT5 SLC15A1 SLC38A6 SLC4A5 SLIT2 SMAD3 SMARCA4 SMARCA5 SMARCC1 SMARCC2 SNCA SNRNP200 SNRNP70 SNX25 SOX9 SP4 SRPK1 SRRM2 SRSF4 STAU1 SUMO2 SUPT16H SYCP1 SYNE1 SYT14 SYVN1 TANK TBCB TERT TEX15 TFIP11 THOC2 THRAP3 TMPO TNPO3 TOP2A TOP2B TP53 TPM4 TPR TPX2 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM22 TRIM31 TRIM54 TRIM55 TRIM63 TRIM8 TRO TSC22D2 TTN U2AF2 UBA52 UBAP2 UBC UBE2D3 UBE2E1 UBE2S UBN1 UBTF UHRF1 UMPS USP21 USP28 UTP14C UTY VARS1 VCP VIM VIRMA VPS13B VPS35 WWP2 XPC XRN2 YY1 ZC3HAV1 ZFR ZGRF1 ZMYM1 ZMYND8 ZNF335 ZNF423 ZNF76
Entrez ID		23294	7874
HPRD ID		10610	03950
Ensembl ID		ENSG00000064999	ENSG00000187555
Uniprot IDs		Q05CP0 Q92625	B7Z855 B7ZAX6 Q6U8A4 Q93009
PDB IDs		2LMR 2MYQ 6F7O	1NB8 1NBF 1YY6 1YZE 2F1W 2F1X 2F1Y 2F1Z 2FOJ 2FOO 2FOP 2KVR 2XXN 2YLM 3MQR 3MQS 4JJQ 4KG9 4M5W 4M5X 4PYZ 4WPH 4WPI 4YOC 4YSI 4Z96 4Z97 5C56 5C6D 5FWI 5GG4 5J7T 5JTJ 5JTV 5KYB 5KYC 5KYD 5KYE 5KYF 5N9R 5N9T 5NGE 5NGF 5UQV 5UQX 5VS6 5VSB 5VSK 5WHC 6F5H 6M1K 6P5L 6VN2 6VN3 6VN4 6VN5 6VN6 7CM2 7VIJ 7XHH 7XHK 7XPY 8D4Z 9DEK 9DEL 9DEM 9DEN 9DEO 9DEP 9FIO 9FIP 9FIQ 9FIR 9FIS 9FIT 9FIU 9FIV 9IJU 9IML
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Protein Binding Structural Constituent Of Skin Epidermis Intermediate Filament Organization Epidermal Growth Factor Receptor Activity Epidermis Development Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process	Nucleus RNA Binding Nucleoplasm Nucleic Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Nucleolus Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription RNA Processing Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process MRNA Processing MRNA Metabolic Process Chromatin Organization RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Positive Regulation Of RNA Biosynthetic Process RNA Splicing Catalytic Step 2 Spliceosome Positive Regulation Of DNA-templated Transcription Nucleic Acid Binding Cellular Response To Stress MRNA Binding Negative Regulation Of DNA-templated Transcription Response To Stress Negative Regulation Of RNA Biosynthetic Process DNA Damage Response DNA Metabolic Process Chromatin Remodeling Protein-containing Complex Spliceosomal Complex
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