ANKS1A and ZNF135

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ANKS1A	ZNF135
Description		ankyrin repeat and sterile alpha motif domain containing 1A	zinc finger protein 135
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cell Projection Neuron Projection	Nucleus
	Molecular Function	Protein Binding Ephrin Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Substrate-dependent Cell Migration Neuron Remodeling Ephrin Receptor Signaling Pathway	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell Morphogenesis
Pathways			Generic Transcription Pathway
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Height ( 23563607 28552196 18391951) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean platelet volume ( 32888494) Non-small cell lung cancer ( 23144319) Obesity-related traits ( 23251661) Platelet distribution width ( 32888494) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172) Waist-hip index ( 34021172)
Interacting Genes		99 interacting genes: ABI2 ACTMAP ADGRL1 ALDOC ANKRD55 ARAP3 ARHGAP10 BCAR1 BLZF1 C17orf50 C22orf39 C3orf36 C9orf152 CADPS CCDC184 CCDC33 CHCHD3 CREBBP CYSRT1 DOK3 EGFR ERBB2 ERBB4 ESM1 FAM217B FAM221A FAM86C1P FCHSD2 FHL5 GOLGA2 GPRIN2 HOXA1 HOXC8 ID3 IKZF3 ISCA2 ITIH6 KCTD9 KEAP1 KIAA1328 KLF15 KLHL26 KPRP KRT31 KRT34 KRT39 KRT75 KRT83 KRTAP10-11 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP19-7 KRTAP4-2 KRTAP6-2 KRTAP9-3 LASP1 LHX2 LNX1 MBD3L1 MED20 MEOX2 MID2 MTUS2 NADSYN1 NBPF19 NEDD9 NHLRC2 NOTCH2NLA NUTM2F PIK3R3 PRDM6 PRKAR1B RANBP3 RB1 RIN1 RNF144B RORB RUSC1 SCN5A SH3KBP1 SHISA6 SLC15A2 SMARCD1 SORBS3 SPATA12 SPRED1 TOX2 TP53BP1 TRIM29 TRIT1 UBC USP54 USP7 YWHAG ZBTB32 ZBTB42 ZC2HC1C ZNF135	10 interacting genes: ANKS1A ANXA7 CDKN1A GADD45A GSK3B LMO4 RAP1B RCC1 SCNM1 WWOX
Entrez ID		23294	7694
HPRD ID		10610	07242
Ensembl ID		ENSG00000064999	ENSG00000176293
Uniprot IDs		Q05CP0 Q92625	B4DLZ7 P52742 Q8N9M3
PDB IDs		2LMR 2MYQ 6F7O
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Protein Binding Structural Constituent Of Skin Epidermis Intermediate Filament Organization Epidermal Growth Factor Receptor Activity Epidermis Development Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process	Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Negative Regulation Of Catalytic Activity Cell Cycle Phase Transition Positive Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Cellular Developmental Process Regulation Of Kinase Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Regulation Of Microtubule Anchoring At Centrosome Apoptotic Signaling Pathway Cellular Response To Ionizing Radiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Protein Phosphorylation Signal Transduction By P53 Class Mediator Regulation Of Phosphorylation Regulation Of Protein-containing Complex Assembly Ventral Spinal Cord Interneuron Differentiation Intracellular Signal Transduction Negative Regulation Of Phosphorylation Regulation Of Cell Cycle Cellular Response To Cell-matrix Adhesion Extrinsic Apoptotic Signaling Pathway Negative Regulation Of TORC2 Signaling Negative Regulation Of Dopaminergic Neuron Differentiation Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Kinase Activity Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Protein-containing Complex Assembly RNA Polymerase II Transcription Regulator Complex Sulfate Binding Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Response To Ionizing Radiation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Phosphate Metabolic Process Oncogene-induced Cell Senescence Stress-induced Premature Senescence Signal Transduction In Response To DNA Damage Negative Regulation Of Protein Metabolic Process
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