ANKS1A and RNF144B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ANKS1A	RNF144B
Description		ankyrin repeat and sterile alpha motif domain containing 1A	ring finger protein 144B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cell Projection Neuron Projection	Ubiquitin Ligase Complex Cytoplasm Mitochondrion Cytosol Membrane Organelle Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Ephrin Receptor Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Substrate-dependent Cell Migration Neuron Remodeling Ephrin Receptor Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Negative Regulation Of Apoptotic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Height ( 23563607 28552196 18391951) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean platelet volume ( 32888494) Non-small cell lung cancer ( 23144319) Obesity-related traits ( 23251661) Platelet distribution width ( 32888494) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172) Waist-hip index ( 34021172)	Adult body size ( 32376654) Age at voice drop ( 27182965) Appendicular lean mass ( 33097823) Caudal middle frontal gyrus volume ( 31530798) Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Endometriosis ( 23472165) Facial morphology ( 31763980) General risk tolerance (MTAG) ( 30643258) Gut microbiota relative abundance (Dorea) ( 33208821) Pulse pressure ( 30224653) Thiopurine S-methyltransferase activity ( 27770449) Triglyceride levels ( 32203549)
Interacting Genes		99 interacting genes: ABI2 ACTMAP ADGRL1 ALDOC ANKRD55 ARAP3 ARHGAP10 BCAR1 BLZF1 C17orf50 C22orf39 C3orf36 C9orf152 CADPS CCDC184 CCDC33 CHCHD3 CREBBP CYSRT1 DOK3 EGFR ERBB2 ERBB4 ESM1 FAM217B FAM221A FAM86C1P FCHSD2 FHL5 GOLGA2 GPRIN2 HOXA1 HOXC8 ID3 IKZF3 ISCA2 ITIH6 KCTD9 KEAP1 KIAA1328 KLF15 KLHL26 KPRP KRT31 KRT34 KRT39 KRT75 KRT83 KRTAP10-11 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP19-7 KRTAP4-2 KRTAP6-2 KRTAP9-3 LASP1 LHX2 LNX1 MBD3L1 MED20 MEOX2 MID2 MTUS2 NADSYN1 NBPF19 NEDD9 NHLRC2 NOTCH2NLA NUTM2F PIK3R3 PRDM6 PRKAR1B RANBP3 RB1 RIN1 RNF144B RORB RUSC1 SCN5A SH3KBP1 SHISA6 SLC15A2 SMARCD1 SORBS3 SPATA12 SPRED1 TOX2 TP53BP1 TRIM29 TRIT1 UBC USP54 USP7 YWHAG ZBTB32 ZBTB42 ZC2HC1C ZNF135	28 interacting genes: ANKS1A CDKN1A CHCHD2 CREB5 FOXH1 IL16 OTX1 PAN2 PAX5 PRKAB2 PROP1 PRR35 RIPPLY1 SGTA SGTB TRAF4 UBC UBE2I UBE2L3 UBE2L6 UBE2T UBE2U UBE2Z UBQLN1 USP15 USP2 VENTX ZIC1
Entrez ID		23294	255488
HPRD ID		10610	17126
Ensembl ID		ENSG00000064999	ENSG00000137393
Uniprot IDs		Q05CP0 Q92625	Q7Z419
PDB IDs		2LMR 2MYQ 6F7O
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Protein Binding Structural Constituent Of Skin Epidermis Intermediate Filament Organization Epidermal Growth Factor Receptor Activity Epidermis Development Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process	Ubiquitin Conjugating Enzyme Activity Ubiquitin-like Protein Transferase Activity Nucleus Proteolysis Involved In Protein Catabolic Process Proteolysis TRC Complex Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Positive Regulation Of Metabolic Process Post-translational Protein Modification Positive Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Modification By Small Protein Conjugation Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of ERAD Pathway Pattern Specification Process Positive Regulation Of RNA Metabolic Process Protein Ubiquitination Cysteine-type Deubiquitinase Activity Regulation Of RNA Metabolic Process Regulation Of ERAD Pathway Catabolic Process Protein Binding Protein Modification Process Protein Targeting To ER Protein Polyubiquitination Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cyclin Binding Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Establishment Of Protein Localization To Endoplasmic Reticulum Diencephalon Morphogenesis SUMO Conjugating Enzyme Activity Negative Regulation Of Store-operated Calcium Channel Activity Protein Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Protein K11-linked Ubiquitination
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