EXOC7 and EXOC4

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		EXOC7	EXOC4
Description		exocyst complex component 7	exocyst complex component 4
Image		No pdb structure
GO Annotations	Cellular Component	Exocyst Cytoplasm Microtubule Organizing Center Cytosol Plasma Membrane Membrane Midbody Growth Cone Membrane Centriolar Satellite Flemming Body	Exocyst Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Microvillus Membrane Growth Cone Membrane Myelin Sheath Abaxonal Region Cell Projection Neuron Projection Synapse Flemming Body
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein-macromolecule Adaptor Activity	Protein Binding PDZ Domain Binding
	Biological Process	Mitotic Cytokinesis Exocytosis Vesicle Docking Involved In Exocytosis Protein Transport Regulation Of Macroautophagy Protein Transmembrane Transport Membrane Fission Vesicle Tethering Involved In Exocytosis Positive Regulation Of Mitotic Cytokinetic Process Regulation Of Entry Of Bacterium Into Host Cell	Mitotic Cytokinesis Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Chemical Synaptic Transmission Protein Transport Regulation Of Macroautophagy Paraxial Mesoderm Formation Protein Transmembrane Transport Membrane Fission Vesicle Tethering Involved In Exocytosis
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654)	Age at first sexual intercourse ( 34211149) Alzheimer's disease (cognitive decline) ( 23535033) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Food allergy ( 29030101) Fruit consumption ( 32066663) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Moderate to vigorous physical activity levels ( 29899525) Mood instability ( 31168069) Peanut allergy ( 29030101) Plasma anti-thyroid peroxidase levels ( 29678681) QT interval ( 29213071) Response to selective serotonin reuptake inhibitors in depression ( 30034349) Subcortical volume (MOSTest) ( 32665545) Tonometry ( 17903302) Vigorous physical activity ( 29899525)
Interacting Genes		40 interacting genes: AKTIP ARFGEF2 ARPC1A BBS1 BBS2 BBS4 CCDC85B CCHCR1 CDC5L CT55 DISC1 DLG3 EXOC2 EXOC4 FBXO28 GRIN2B HGS IFT20 KDM1A KIFC3 KXD1 MSGN1 NRIP1 OLIG2 PKNOX1 PLEKHF2 PRPF19 RALA RALY RHOQ RTN4IP1 SAPCD2 SMARCE1 SNAPIN SSC5D TRAF4 TRIM54 USHBP1 YAE1 ZC3H14	16 interacting genes: BIRC6 CCHCR1 CEP63 DISC1 DLG3 DLG4 DLGAP4 EXOC7 GOLGA1 GRIN2B ING1 MBD3 RALA SMARCE1 TTC3 WEE2-AS1
Entrez ID		23265	60412
HPRD ID		16292	12185
Ensembl ID		ENSG00000182473	ENSG00000131558
Uniprot IDs		B4DJ07 B5MCY9 Q9UPT5	Q6NX51 Q96A65
PDB IDs			7PC5
Enriched GO Terms of Interacting Partners?		BBSome Golgi To Plasma Membrane Transport Vesicle-mediated Transport To The Plasma Membrane Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Vesicle-mediated Transport Localization Within Membrane Cytoskeleton Intracellular Protein Localization Cellular Localization Protein Transport Establishment Of Protein Localization Post-Golgi Vesicle-mediated Transport Striatum Development Regulation Of Cilium Beat Frequency Non-motile Cilium Assembly Microtubule-based Process Brain Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Endosome Organization Cerebral Cortex Development Flemming Body Protein Binding Regulation Of Cilium Movement Organelle Localization Exocytosis Centrosome Photoreceptor Cell Maintenance Motile Cilium Regulation Of Lysosome Size BORC Complex Membrane Fission Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Projection Organization Cytoplasm Vesicle Tethering Involved In Exocytosis Lysosomal Transport Leptin-mediated Signaling Pathway Regulation Of Microtubule-based Movement Ciliary Membrane Regulation Of Endosome Size Endosome To Lysosome Transport Cilium Assembly Negative Regulation Of Appetite Establishment Of Organelle Localization Protein Localization To Cilium DNA Replication Factor A Complex Cytoplasmic Side Of Lysosomal Membrane Golgi Vesicle Transport	Flemming Body Synaptic Membrane Neuromuscular Junction Microtubule Organizing Center Postsynaptic Density Membrane Ionotropic Glutamate Receptor Binding AMPA Glutamate Receptor Complex Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Synapse Maturation Positive Regulation Of Excitatory Postsynaptic Potential Response To Methotrexate Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Clustering Receptor Localization To Synapse P2Y1 Nucleotide Receptor Binding Glutamate Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Modulation Of Chemical Synaptic Transmission Positive Regulation Of Stem Cell Population Maintenance Nucleosomal DNA Binding Molecular Adaptor Activity Protein Localization To Synapse Regulation Of Neuronal Synaptic Plasticity
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