EXOC7 and ARFGEF2

Number of citations of the paper that reports this interaction (PubMedID 15705715)
26

Data Source:
HPRD (two hybrid)

		EXOC7	ARFGEF2
Description		exocyst complex component 7	ARF guanine nucleotide exchange factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Exocyst Cytoplasm Microtubule Organizing Center Cytosol Plasma Membrane Membrane Midbody Growth Cone Membrane Centriolar Satellite Flemming Body	Golgi Membrane Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Axonemal Microtubule Membrane Dendrite Cytoplasmic Vesicle Asymmetric Synapse Symmetric Synapse Cell Projection Dendritic Spine Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein-macromolecule Adaptor Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Myosin Binding Protein Kinase A Regulatory Subunit Binding GABA Receptor Binding
	Biological Process	Mitotic Cytokinesis Exocytosis Vesicle Docking Involved In Exocytosis Protein Transport Regulation Of Macroautophagy Protein Transmembrane Transport Membrane Fission Vesicle Tethering Involved In Exocytosis Positive Regulation Of Mitotic Cytokinetic Process Regulation Of Entry Of Bacterium Into Host Cell	Receptor Recycling Exocytosis Golgi To Plasma Membrane Transport Endosome Organization Endomembrane System Organization Protein Transport Vesicle-mediated Transport Regulation Of ARF Protein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium	Association of TriC/CCT with target proteins during biosynthesis
Drugs
Diseases			Periventricular nodular heterotopia (PVNH)
GWAS		Body size at age 10 ( 32376654)	Adult body size ( 32376654) Anger ( 24489884) Birth weight ( 31043758) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Offspring birth weight ( 31043758) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		40 interacting genes: AKTIP ARFGEF2 ARPC1A BBS1 BBS2 BBS4 CCDC85B CCHCR1 CDC5L CT55 DISC1 DLG3 EXOC2 EXOC4 FBXO28 GRIN2B HGS IFT20 KDM1A KIFC3 KXD1 MSGN1 NRIP1 OLIG2 PKNOX1 PLEKHF2 PRPF19 RALA RALY RHOQ RTN4IP1 SAPCD2 SMARCE1 SNAPIN SSC5D TRAF4 TRIM54 USHBP1 YAE1 ZC3H14	10 interacting genes: ARFGEF1 EXOC7 GABRB1 GABRB2 GABRB3 LCOR PNPLA2 PRKAR1A PRKAR2A PRPF40A
Entrez ID		23265	10564
HPRD ID		16292	09250
Ensembl ID		ENSG00000182473	ENSG00000124198
Uniprot IDs		B4DJ07 B5MCY9 Q9UPT5	A0A7P0T7Z2 Q59FR3 Q86TH5 Q9Y6D5
PDB IDs			3L8N 3SWV
Enriched GO Terms of Interacting Partners?		BBSome Golgi To Plasma Membrane Transport Vesicle-mediated Transport To The Plasma Membrane Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Vesicle-mediated Transport Localization Within Membrane Cytoskeleton Intracellular Protein Localization Cellular Localization Protein Transport Establishment Of Protein Localization Post-Golgi Vesicle-mediated Transport Striatum Development Regulation Of Cilium Beat Frequency Non-motile Cilium Assembly Microtubule-based Process Brain Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Endosome Organization Cerebral Cortex Development Flemming Body Protein Binding Regulation Of Cilium Movement Organelle Localization Exocytosis Centrosome Photoreceptor Cell Maintenance Motile Cilium Regulation Of Lysosome Size BORC Complex Membrane Fission Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Projection Organization Cytoplasm Vesicle Tethering Involved In Exocytosis Lysosomal Transport Leptin-mediated Signaling Pathway Regulation Of Microtubule-based Movement Ciliary Membrane Regulation Of Endosome Size Endosome To Lysosome Transport Cilium Assembly Negative Regulation Of Appetite Establishment Of Organelle Localization Protein Localization To Cilium DNA Replication Factor A Complex Cytoplasmic Side Of Lysosomal Membrane Golgi Vesicle Transport	Cellular Response To Histamine Response To Histamine GABA-A Receptor Activity GABA-gated Chloride Ion Channel Activity GABA-A Receptor Complex Gamma-aminobutyric Acid Signaling Pathway Postsynaptic Specialization Membrane Synaptic Transmission, GABAergic Extracellular Ligand-gated Monoatomic Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Chloride Channel Complex CAMP-dependent Protein Kinase Regulator Activity Chloride Channel Activity CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Nucleotide-activated Protein Kinase Complex Inner Ear Receptor Cell Development Chloride Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Protein Kinase A Catalytic Subunit Binding GABA-ergic Synapse Chloride Transport Inorganic Anion Transmembrane Transport Regulation Of Biological Quality Innervation CAMP Binding Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Inhibitory Synapse Assembly Negative Regulation Of CAMP/PKA Signal Transduction Monoatomic Ion Channel Activity Neuron Development Cochlea Development Plasma Membrane Raft Membrane Ciliary Base Transmembrane Signaling Receptor Activity Regulation Of CAMP/PKA Signal Transduction Postsynaptic Membrane Transmembrane Transport Circadian Sleep/wake Cycle, REM Sleep Prostaglandin-I Synthase Activity Inorganic Ion Transmembrane Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Membrane Potential Trans-synaptic Signaling Synaptic Signaling Regulation Of Cytokinesis
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