SIK2 and VCP

Number of citations of the paper that reports this interaction (PMID 24129571)
0

Data Source:
BioGRID (enzymatic study)

		SIK2	VCP
Gene Name		salt-inducible kinase 2	valosin containing protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Proteasome Complex Hrd1p Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Particle Cytosol Site Of Double-strand Break Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Receptor Binding Protein Binding ATP Binding Lipid Binding ATPase Activity Protein Phosphatase Binding Protein Domain Specific Binding Polyubiquitin Binding Protein Complex Binding Deubiquitinase Activator Activity Identical Protein Binding ADP Binding Poly(A) RNA Binding Ubiquitin-specific Protease Binding
	Biological Process	Protein Phosphorylation Insulin Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Insulin Receptor Signaling Pathway Protein Autophosphorylation	DNA Repair Double-strand Break Repair ER To Golgi Vesicle-mediated Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Ubiquitination Protein N-linked Glycosylation Via Asparagine Translesion Synthesis ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Hexamerization Cellular Response To Heat Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Protein Homooligomerization Aggresome Assembly Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Lys63-specific Deubiquitinase Activity
Pathways			HSF1 activation Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease Signaling by Hedgehog Cellular response to heat stress
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: APP CRTC2 GABARAPL2 HDAC5 IRS1 VCP	72 interactors: AMFR AR ASPSCR1 ATG5 ATXN1 ATXN3 ATXN7 BRCA1 BRSK2 CAV1 CEP19 CRMP1 DERL1 DGCR6 DTNB FAM104A GZMK HDAC6 HERPUD1 HTT INSIG1 INSIG2 JAK2 LNX1 MAPK8IP2 NDRG1 NF1 NFKBIA NGLY1 NPLOC4 NSFL1C NUB1 OTULIN PLAA PRKCD PSMA1 PSMA7 PSMC1 PTPN3 RNF19A RNF31 RNF8 RPL9 RPS6KA1 SH2D2A SIK2 STUB1 STX5 SUMO4 SVIP SYVN1 TOM1L1 TOMM34 UBE4A UBE4B UBOX5 UBQLN1 UBXN1 UBXN2A UBXN2B UBXN6 UFD1L VCPIP1 VCPKMT VIMP WAC WBSCR22 WDYHV1 WRN YOD1 YWHAZ ZFAND2B
Entrez ID		23235	7415
HPRD ID		12348	03013
Ensembl ID			ENSG00000165280
Uniprot IDs		Q9H0K1	P55072 Q96IF9
PDB IDs			3EBB 3HU1 3HU2 3HU3 3QC8 3QQ7 3QQ8 3QWZ 3TIW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Histone H3-K9 Modification Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Cellular Biosynthetic Process Response To Stress Regulation Of Proteolysis Histone H3-K9 Acetylation Synaptic Growth At Neuromuscular Junction Notch Signaling Pathway Cellular Component Assembly Positive Regulation Of Peptidase Activity Regulation Of Protein Binding Collateral Sprouting In Absence Of Injury Chemical Homeostasis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Metabolic Process Glucose Homeostasis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Insulin Stimulus Collateral Sprouting Axon Midline Choice Point Recognition Retrograde Protein Transport, ER To Cytosol Regulation Of Catalytic Activity Cellular Localization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Protein Deubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hydrolase Activity Axon Choice Point Recognition Protein Hexamerization Protein Homooligomerization Regulation Of Binding Golgi Vesicle Transport Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Response To Insulin Positive Regulation Of Proteolysis Neuron Remodeling Cellular Response To Peptide Hormone Stimulus Aggresome Assembly Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Peptide Positive Regulation Of Fatty Acid Beta-oxidation Translesion Synthesis Positive Regulation Of Transcription, DNA-templated Defense Response Negative Regulation Of Proteolysis	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Protein Modification By Small Protein Conjugation Protein Ubiquitination Response To Stress Catabolic Process Protein Metabolic Process Protein Polyubiquitination Cellular Metabolic Process Regulation Of Protein Ubiquitination Cellular Protein Modification Process Cellular Response To Topologically Incorrect Protein ER-nucleus Signaling Pathway Golgi Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cell Communication Regulation Of Protein Catabolic Process Response To Endoplasmic Reticulum Stress ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stimulus Negative Regulation Of Apoptotic Process Regulation Of Proteolysis Negative Regulation Of Programmed Cell Death Regulation Of Cell Death Negative Regulation Of Cellular Protein Metabolic Process Apoptotic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Metabolic Process Negative Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Cellular Response To Unfolded Protein Programmed Cell Death Negative Regulation Of Protein Metabolic Process Cell Death Death Negative Regulation Of Signal Transduction Response To Stimulus Response To Unfolded Protein Negative Regulation Of Signaling
Tagcloud ?		43delta abrogated adipocyte amp ampk autophagosome autophagosomes autophagy belonging coordinated deacetylation determinant elusive hdac6 hormones indispensable interplay k53q k53r lys lysosome mimetic nonacetylatable nutrients pool restores switch threonine uncover	17q11 3q28 9pter ap2 ap50 aps blots clapb1 clapm1 clathrin coated denoted designated dnas endocytosis lattice locations mapped maps oligonucleotide porcine primers probe q12 q34 rodent served stoichiometric triskelia
Tagcloud (Difference) ?		43delta abrogated adipocyte amp ampk autophagosome autophagosomes autophagy belonging coordinated deacetylation determinant elusive hdac6 hormones indispensable interplay k53q k53r lys lysosome mimetic nonacetylatable nutrients pool restores switch threonine uncover	17q11 3q28 9pter ap2 ap50 aps blots clapb1 clapm1 clathrin coated denoted designated dnas endocytosis lattice locations mapped maps oligonucleotide porcine primers probe q12 q34 rodent served stoichiometric triskelia
Tagcloud (Intersection) ?