SIK2 and CRTC2

Number of citations of the paper that reports this interaction (PMID 15454081)
140

Data Source:
BioGRID (affinity chromatography technology, enzymatic study, enzymatic study)
HPRD (in vitro, in vivo)

		SIK2	CRTC2
Gene Name		salt-inducible kinase 2	CREB regulated transcription coactivator 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleoplasm Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Binding CAMP Response Element Binding Protein Binding
	Biological Process	Protein Phosphorylation Insulin Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Insulin Receptor Signaling Pathway Protein Autophosphorylation	Gluconeogenesis Transcription, DNA-templated Viral Process Positive Regulation Of CREB Transcription Factor Activity Glucose Homeostasis Histone H3-K9 Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Homotetramerization Toxin Transport
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: APP CRTC2 GABARAPL2 HDAC5 IRS1 VCP	9 interactors: PPP3CA PRKAA1 SIK1 SIK2 SIK3 UBC YWHAB YWHAG YWHAZ
Entrez ID		23235	200186
HPRD ID		12348	12347
Ensembl ID			ENSG00000160741
Uniprot IDs		Q9H0K1	Q53ET0
PDB IDs			4HTM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Histone H3-K9 Modification Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Cellular Biosynthetic Process Response To Stress Regulation Of Proteolysis Histone H3-K9 Acetylation Synaptic Growth At Neuromuscular Junction Notch Signaling Pathway Cellular Component Assembly Positive Regulation Of Peptidase Activity Regulation Of Protein Binding Collateral Sprouting In Absence Of Injury Chemical Homeostasis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Metabolic Process Glucose Homeostasis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Insulin Stimulus Collateral Sprouting Axon Midline Choice Point Recognition Retrograde Protein Transport, ER To Cytosol Regulation Of Catalytic Activity Cellular Localization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Protein Deubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hydrolase Activity Axon Choice Point Recognition Protein Hexamerization Protein Homooligomerization Regulation Of Binding Golgi Vesicle Transport Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Response To Insulin Positive Regulation Of Proteolysis Neuron Remodeling Cellular Response To Peptide Hormone Stimulus Aggresome Assembly Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Peptide Positive Regulation Of Fatty Acid Beta-oxidation Translesion Synthesis Positive Regulation Of Transcription, DNA-templated Defense Response Negative Regulation Of Proteolysis	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Phosphate-containing Compound Metabolic Process Phosphorylation Intracellular Signal Transduction Cellular Response To Insulin Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Cell Death Response To Insulin Cellular Response To Peptide Hormone Stimulus Regulation Of Apoptotic Process Cellular Response To Peptide Regulation Of Protein Localization Regulation Of Mitochondrion Organization Apoptotic Signaling Pathway Regulation Of Cell Death Response To Organonitrogen Compound Protein Targeting Regulation Of Intracellular Transport Response To Peptide Hormone Cellular Response To Organic Substance Cellular Response To Organonitrogen Compound Regulation Of Signaling Response To Peptide Insulin Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway Cellular Response To Hormone Stimulus Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Cell Cycle Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Signaling Cell Communication Response To Organic Substance Mitotic Cell Cycle Phase Transition Positive Regulation Of Transport Regulation Of Protein Kinase Activity Cell Cycle Phase Transition Intracellular Transport Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Negative Regulation Of Lipid Biosynthetic Process Regulation Of Kinase Activity
Tagcloud ?		43delta abrogated adipocyte amp ampk autophagosome autophagosomes autophagy belonging coordinated deacetylation determinant elusive hdac6 hormones indispensable interplay k53q k53r lys lysosome mimetic nonacetylatable nutrients pool restores switch threonine uncover	autocrine calcitonin cgrp cofactor competes costimulatory creb crtc3 engagement enhancing exhibits glycoprotein herpesvirus hsv lymphotoxin macrophage macrophages mediator modulates nerves neuroimmunological neuropeptide shape sphingosine sphk1 stimulatory sustained tlr4
Tagcloud (Difference) ?		43delta abrogated adipocyte amp ampk autophagosome autophagosomes autophagy belonging coordinated deacetylation determinant elusive hdac6 hormones indispensable interplay k53q k53r lys lysosome mimetic nonacetylatable nutrients pool restores switch threonine uncover	autocrine calcitonin cgrp cofactor competes costimulatory creb crtc3 engagement enhancing exhibits glycoprotein herpesvirus hsv lymphotoxin macrophage macrophages mediator modulates nerves neuroimmunological neuropeptide shape sphingosine sphk1 stimulatory sustained tlr4
Tagcloud (Intersection) ?