SIK2

Description		salt inducible kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Lipid Biosynthetic Process Intracellular Signal Transduction ERAD Pathway Regulation Of Insulin Receptor Signaling Pathway Protein Autophosphorylation
Pathways
Drugs		Fostamatinib
Diseases
GWAS		A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Asthma ( 34103634 30929738 31361310 31619474 32296059) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Eosinophil percentage of white cells ( 32888494) Fish- and plant-related diet ( 32066663) Household income (MTAG) ( 31844048) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Primary sclerosing cholangitis ( 23603763 27992413) Triglyceride levels ( 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		8 interacting genes: APP CRTC2 CRTC3 EP300 FBXW7 GABARAPL2 HDAC5 IRS1
Entrez ID		23235
HPRD ID		12348
Ensembl ID		ENSG00000170145
Uniprot IDs		Q9H0K1
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Oxygen-containing Compound Cellular Response To CAMP Positive Regulation Of Transcription By RNA Polymerase II Protein Tetramerization Response To CAMP CAMP Response Element Binding Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Catabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Generation Of Precursor Metabolites And Energy Response To Purine-containing Compound Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Insulin Receptor Binding Regulation Of Establishment Of Protein Localization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Leukocyte Activation Protein Homooligomerization Positive Regulation Of Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Macromolecule Metabolic Process Homeostatic Process Cell Activation Protein Complex Oligomerization Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Protein Kinase C Binding Protein-containing Complex Positive Regulation Of Gene Expression, Epigenetic Regulation Of Glycolytic Process Gluconeogenesis Transcription Coactivator Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Negative Regulation Of Metabolic Process Myeloid Cell Development Chemical Homeostasis Response To Light Stimulus Positive Regulation Of Establishment Of Protein Localization Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Regulation Of Carbohydrate Catabolic Process Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway
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