TTLL12 and FILNC1

Number of citations of the paper that reports this interaction (PubMedID 28978906)
44

Data Source:
BioGRID (unspecified method)

		TTLL12	FILNC1
Description		tubulin tyrosine ligase like 12	FOXO induced long non-coding RNA 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Midbody
	Molecular Function	Nucleotide Binding Tubulin-tyrosine Ligase Activity Protein Binding ATP Binding Histone H4K20me2 Reader Activity Histone H4K20 Trimethyltransferase Activity
	Biological Process	Immune System Process Chromatin Organization Regulation Of Mitotic Cell Cycle Innate Immune Response Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways		Carboxyterminal post-translational modifications of tubulin
Drugs
Diseases
GWAS		Molar-incisor hypomineralization ( 23918034) Monocyte count ( 27863252 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494)	Heel bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		10 interacting genes: CEBPA CSNK2A2 DNAJB1 EEF1A1 EEF1A2 FAM222B FILNC1 LCOR PRR35 SUMO2	88 interacting genes: AAAS ABCC1 ACTN1 ACTR2 AHSA1 AIMP2 AKAP8 ALDH1B1 AP1B1 AP3D1 ARAP1 ARF6 ATP2A2 CAND1 CCT6B CLPX CNDP2 COPG1 DDX24 DNM1 DNM1L DPM1 DYNC1H1 EEF1D EEF2 ERLIN1 GALK1 GMPS GSTO1 HDLBP HNRNPA0 HNRNPD HSPA1A IDH1 KTN1 LAMC1 LAS1L MAP1S MCM3 MRPL4 MSH2 MTHFD1L MYL12A NIBAN2 NKRF NOP56 NPEPPSP1 NSF NUP153 OASL OGT PCAT1 PDCD4 PES1 PFAS PLS3 PPME1 PSMC2 PSMC4 PSMD14 PSMD5 PURA QNG1 RIGI RO60 RPL13A RPS5 RPSA SART1 STT3B STXBP2 TAGLN2 TIMM50 TMEM126A TMX3 TRIP13 TTLL12 TTN U2AF1 UBA52 UBE4A VPS35 WARS1 XPO1 XPOT XRCC6 YWHAB ZCCHC8
Entrez ID		23170	100132735
HPRD ID		13782
Ensembl ID		ENSG00000100304	ENSG00000231426
Uniprot IDs		Q14166
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Catabolic Process Eukaryotic Translation Elongation Factor 1 Complex Regulation Of Chaperone-mediated Autophagy Cytoplasmic Side Of Lysosomal Membrane Translation Elongation Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Translational Elongation Positive Regulation Of Lipid Kinase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Response To Vitamin B2 C/EBP Complex Regulation Of Protein Metabolic Process Regulation Of Autophagy Kinase Binding CHOP-C/EBP Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Liver Development Protein Kinase CK2 Complex Positive Regulation Of Protein Folding Positive Regulation Of Proteasomal Protein Catabolic Process White Fat Cell Proliferation Regulation Of Lipid Kinase Activity Histone Deacetylase Binding Regeneration Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex	RNA Binding Cytosol ATP Hydrolysis Activity Nucleotide Binding Cadherin Binding Ribonucleoprotein Complex Ficolin-1-rich Granule Lumen ATP Binding Extracellular Exosome Proteasome Accessory Complex Cytoplasm Translation Intracellular Transport Proteasome Regulatory Particle, Base Subcomplex Secretory Granule Lumen Nucleoplasm Actin Filament Binding Macromolecule Metabolic Process Nucleolus Mitochondrion-derived Vesicle Intracellular Protein Transport Organelle Localization Cellular Localization Establishment Of Localization In Cell Proteasome Complex Nucleobase-containing Compound Metabolic Process Actin Filament Network Formation ATP-dependent Protein Disaggregase Activity Proteasome-activating Activity LncRNA Binding Membrane Coat Ribosome Cytoplasmic Translation Establishment Of Organelle Localization Double-stranded DNA Binding Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Establishment Of Protein Localization ATP-dependent Protein Folding Chaperone Cellular Component Assembly Regulation Of Cytoplasmic Translation
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