TTLL12 and EEF1A2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TTLL12	EEF1A2
Description		tubulin tyrosine ligase like 12	eukaryotic translation elongation factor 1 alpha 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Midbody	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Eukaryotic Translation Elongation Factor 1 Complex Membrane Synapse Cytoplasmic Side Of Lysosomal Membrane
	Molecular Function	Nucleotide Binding Tubulin-tyrosine Ligase Activity Protein Binding ATP Binding Histone H4K20me2 Reader Activity Histone H4K20 Trimethyltransferase Activity	Nucleotide Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Translation Factor Activity, RNA Binding Hydrolase Activity Protein Kinase Binding Metal Ion Binding
	Biological Process	Immune System Process Chromatin Organization Regulation Of Mitotic Cell Cycle Innate Immune Response Negative Regulation Of Type I Interferon-mediated Signaling Pathway	Translation Translational Elongation Positive Regulation Of Apoptotic Process Positive Regulation Of Lipid Kinase Activity Regulation Of Chaperone-mediated Autophagy
Pathways		Carboxyterminal post-translational modifications of tubulin	Eukaryotic Translation Elongation
Drugs			Plitidepsin
Diseases
GWAS		Molar-incisor hypomineralization ( 23918034) Monocyte count ( 27863252 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Prostate cancer ( 23535732) Serum metabolite levels ( 33031748)
Interacting Genes		10 interacting genes: CEBPA CSNK2A2 DNAJB1 EEF1A1 EEF1A2 FAM222B FILNC1 LCOR PRR35 SUMO2	12 interacting genes: CHRM4 ERG HUNK LINC00941 MAPK6 PKNOX1 SMN1 STK11 SUMO2 TSPY1 TTLL12 UBE3A
Entrez ID		23170	1917
HPRD ID		13782	04265
Ensembl ID		ENSG00000100304	ENSG00000101210
Uniprot IDs		Q14166	Q05639
PDB IDs			3C5J 8B6Z
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Catabolic Process Eukaryotic Translation Elongation Factor 1 Complex Regulation Of Chaperone-mediated Autophagy Cytoplasmic Side Of Lysosomal Membrane Translation Elongation Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Translational Elongation Positive Regulation Of Lipid Kinase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Response To Vitamin B2 C/EBP Complex Regulation Of Protein Metabolic Process Regulation Of Autophagy Kinase Binding CHOP-C/EBP Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Liver Development Protein Kinase CK2 Complex Positive Regulation Of Protein Folding Positive Regulation Of Proteasomal Protein Catabolic Process White Fat Cell Proliferation Regulation Of Lipid Kinase Activity Histone Deacetylase Binding Regeneration Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex
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