MAPK9 and PRKD1

Number of citations of the paper that reports this interaction (PubMedID 11948398)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		MAPK9	PRKD1
Description		mitogen-activated protein kinase 9	protein kinase D1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Nuclear Speck Schaffer Collateral - CA1 Synapse	Autophagosome Membrane Nucleus Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Cell-cell Junction Cell Cortex Membrane Z Disc Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Activity MAP Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Heat Shock Protein Binding Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity Phosphatidylinositol 3-kinase Activator Activity
	Biological Process	MAPK Cascade Protein Phosphorylation JNK Cascade Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Reactive Oxygen Species Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Regulation Of MRNA Stability Response To Cadmium Ion Rhythmic Process Modulation Of Chemical Synaptic Transmission MRNA Destabilization Protein Localization To Tricellular Tight Junction Positive Regulation Of Podosome Assembly Cellular Senescence Inflammatory Response To Wounding Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Apoptotic Signaling Pathway	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Immune System Process Apoptotic Process Inflammatory Response Golgi Organization Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Nervous System Development Positive Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril Sphingolipid Biosynthetic Process Cell Differentiation Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell-cell Adhesion Mediated By Cadherin Innate Immune Response Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Size Negative Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Positive Regulation Of Protein Export From Nucleus Vascular Endothelial Growth Factor Receptor Signaling Pathway Golgi Vesicle Transport Defense Response To Gram-negative Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Sarcomere Organization Transepithelial Transport Cellular Response To Hydroperoxide Response To Norepinephrine Cellular Response To Norepinephrine Stimulus Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of NLRP3 Inflammasome Complex Assembly Cellular Response To Angiotensin Cellular Response To Phorbol 13-acetate 12-myristate Cellular Response To Endothelin Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Integrin-mediated Signaling Pathway
Pathways		Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors Signaling by ALK fusions and activated point mutants	Sphingolipid de novo biosynthesis
Drugs		Minocycline N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide Fostamatinib Halicin	Bryostatin 1 Fostamatinib
Diseases
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576)	Academic attainment (English) ( 33594131) Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 20935630 23669352 25673413 28552196 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) California verbal learning test score ( 31596458) Carotid plaque burden ( 28282560) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Childhood body mass index ( 26604143) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Daytime nap ( 33568662) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hip circumference ( 28552196) Household income (MTAG) ( 31844048) IgM levels ( 28628107) Intelligence (MTAG) ( 29326435) Neurociticism ( 29500382) Obesity-related traits ( 23251661) Schizophrenia ( 30285260 29483656 25056061 34099189) Spatial processing ( 31596458) Systolic blood pressure ( 30224653) Type 2 diabetes ( 30130595) Urinary sodium excretion ( 31409800) Waist circumference ( 28552196 25673412) Weight ( 28552196)
Interacting Genes		111 interacting genes: ACP5 AKT1 ARRB1 ARRB2 ATF2 ATF7 BCL2L1 BCL2L11 BTRC C1orf105 C1orf94 CASP3 CBLL2 CCDC33 CDC16 CDC25B CDC25C CEP126 CEP44 CLU CTBP1 CTNNB1 DCX DTX3 DUSP10 DUSP16 DUSP19 DUSP4 EEF2K EFHC2 EGFR ELK1 ELK3 ENKD1 FBXO7 GFAP GOLGA6A GRB2 GSC2 H3-3A HDAC9 HSF1 IHO1 IRS1 ITGB3BP JDP2 JUN JUNB JUND KLHL8 KPNA3 L3MBTL3 LHX3 LMAN2 LNX1 LNX2 LZTS1 MACF1 MAP2K4 MAP2K7 MAP3K1 MAP3K10 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAPK5 MAPKBP1 MAPT MCRS1 MED12L MEOX1 MLIP NCF1 NCSTN NFATC3 NFATC4 NHSL2 PAX5 PBX4 PICK1 POU6F2 PPARG PRKD1 PSEN1 RB1 RPS6KB1 RSPO4 SAXO1 SDCBP SF3B4 SH3BP5 SHMT1 SMAD2 SMAD3 SMCO3 SSU72 TCP10L TEX11 TOB1 TP53 TRAF2 TUSC2 WDR62 XPNPEP1 XPO7 ZBTB25 ZC2HC1C ZFTRAF1 ZNF138 ZNF559 ZNHIT1	33 interacting genes: ABL1 ADAP1 AKAP13 BTK C1QBP COPS2 COPS5 COPS7A EGFR EPAS1 HDAC5 HDAC7 IBTK IGF1R JUN KIDINS220 MAPK8 MAPK9 MT2A NOS1 PLCG1 PLCG2 PPP1R14A PRKCE PRKCH RACK1 SPRY2 SRC SYK TFAP2A TP53 USP28 YWHAQ
Entrez ID		5601	5587
HPRD ID		04206	05668
Ensembl ID		ENSG00000050748	ENSG00000184304
Uniprot IDs		D7R525 P45984	F8WBA3 Q15139
PDB IDs		3E7O 3NPC 7CML 7N8T 8ELC
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Intracellular Signal Transduction MAPK Cascade Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Protein Kinase Binding Cellular Developmental Process Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway Nucleus Positive Regulation Of Transcription By RNA Polymerase II JNK Cascade JUN Kinase Binding Programmed Cell Death Cell Death Negative Regulation Of Apoptotic Process Cytoplasm Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Population Proliferation Regulation Of Macromolecule Metabolic Process Protein Binding Negative Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process	Intracellular Signaling Cassette Fc Receptor Signaling Pathway Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Assembly Cytosol Positive Regulation Of Cell Migration Regulation Of Apoptotic Process Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Protein Metabolic Process Regulation Of Protein Modification Process Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Enzyme Binding Signal Transduction Regulation Of Protein-containing Complex Assembly Negative Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein-containing Complex Negative Regulation Of Macromolecule Metabolic Process Protein Phosphorylation Regulation Of Post-translational Protein Modification Positive Regulation Of Intracellular Signal Transduction Kinase Activity Protein Kinase C Binding Response To Lipid Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Positive Regulation Of Epithelial Cell Migration Protein Kinase Activity Cell Activation Regulation Of Protein Neddylation Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Motility Cellular Response To Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Immune Response-regulating Signaling Pathway Regulation Of Locomotion Positive Regulation Of Programmed Cell Death
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