MAPK9 and TUSC2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MAPK9	TUSC2
Gene Name		mitogen-activated protein kinase 9	tumor suppressor candidate 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol	Mitochondrion
	Molecular Function	JUN Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Positive Regulation Of Protein Phosphorylation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Protein Targeting To Mitochondrion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Stress JNK Cascade JUN Phosphorylation Central Nervous System Development Response To Mechanical Stimulus Response To Toxic Substance Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cell Morphogenesis Involved In Differentiation Response To Amine Neuron Projection Development Positive Regulation Of Prostaglandin Biosynthetic Process Regulation Of Protein Ubiquitination Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Chemokine Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To UV TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Response To Drug Regulation Of Circadian Rhythm Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of JNK Cascade Response To Cadmium Ion Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Stress-activated MAPK Cascade Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Signaling Pathway	Natural Killer Cell Differentiation Phagocytosis Inflammatory Response Cell Cycle Cell-cell Signaling Cell Proliferation Interleukin-15 Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-10 Production Cell Maturation Regulation Of Mitochondrial Membrane Potential Response To Defense-related Host Reactive Oxygen Species Production Neutrophil Mediated Killing Of Gram-negative Bacterium Chemokine (C-C Motif) Ligand 5 Production Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Innate Immune System TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Oxidative Stress Induced Senescence Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling MAPK targets/ Nuclear events mediated by MAP kinases
Drugs
Diseases
GWAS
Protein-Protein Interactions		70 interactors: ACP5 ARRB1 ARRB2 ATF2 ATF7 BAZ1B BCL2L11 C1orf94 CASP3 CCDC33 CDC25B CDC25C CEP44 CLU CTBP1 CTNNB1 CYHR1 DUSP16 DUSP19 DUSP4 EEF2K EFHC2 ELK1 ELK3 GRB2 H3F3A HDAC9 HSF1 IRS1 JDP2 JUN JUNB JUND KIAA1377 L3MBTL3 LMAN2 LNX1 MACF1 MAP2K4 MAP2K7 MAP3K1 MAP3K10 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAPK5 MAPKBP1 MEOX1 NCF1 NFATC3 NFATC4 PRKD1 RB1 RPS6KB1 SF3B4 SH3BP5 SHMT1 SMAD2 SMAD3 SMCO3 SSU72 TEX11 TOB1 TP53 TRAF2 TUSC2 WDR62 XPNPEP1 XPO7 ZBTB25	3 interactors: MAPK9 MDFI RBPMS
Entrez ID		5601	11334
HPRD ID		04206	06134
Ensembl ID		ENSG00000050748	ENSG00000114383
Uniprot IDs		P45984	O75896
PDB IDs		3E7O 3NPC
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Response To Stress Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process MAPK Cascade Intracellular Signal Transduction Regulation Of Kinase Activity Apoptotic Process Regulation Of Protein Kinase Activity Signal Transduction By Phosphorylation Negative Regulation Of Cellular Metabolic Process Programmed Cell Death Cell Death Death Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of MAPK Cascade Positive Regulation Of Cellular Biosynthetic Process Developmental Process Regulation Of Cellular Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Neuron Death Positive Regulation Of Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Defense Response Cellular Metabolic Process Cellular Response To Stress Regulation Of Signaling Regulation Of Gene Expression Anatomical Structure Development Cell Differentiation Positive Regulation Of Phosphorylation Signal Transduction Toll-like Receptor 4 Signaling Pathway Immune System Process Transcription From RNA Polymerase II Promoter Regulation Of Catalytic Activity Regulation Of JUN Kinase Activity Signaling	Positive Regulation Of Protein Phosphorylation JNK Cascade Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of JNK Cascade Positive Regulation Of Protein Metabolic Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Stress-activated MAPK Cascade Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Regulation Of Phosphorus Metabolic Process MAPK Cascade Regulation Of Intracellular Protein Transport Signal Transduction By Phosphorylation JUN Phosphorylation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Prostaglandin Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Intracellular Transport Positive Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of MAPK Cascade Regulation Of Protein Transport Regulation Of SMAD Protein Import Into Nucleus Trophoblast Giant Cell Differentiation Regulation Of Signaling Positive Regulation Of Icosanoid Secretion Regulation Of Establishment Of Protein Localization Cytoplasmic Sequestering Of Transcription Factor Dorsal/ventral Axis Specification Positive Regulation Of Transport Positive Regulation Of Fatty Acid Transport Positive Regulation Of Metabolic Process Cytoplasmic Sequestering Of Protein Regulation Of Protein Localization Positive Regulation Of Macrophage Derived Foam Cell Differentiation Release Of Cytochrome C From Mitochondria Positive Regulation Of Fatty Acid Metabolic Process Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Fatty Acid Transport
Tagcloud ?		abeta1 autophagic autophagosomes autophagy bcl2 beclin becn1 buildup digested elevation favor favoring flux hamper incompletely jnk1 jnk2 lc3 lysosomal mapk8 modifying monomers neuroblastoma oligomers phosphorylating profound sk turn vacuoles	3beta accelerated balanced catastrophe crypt cyclins cytochrome dysregulated exhibiting follicles fus1 gammah2ax gi gsk hair individualized irradiation maintaining nfkappab parp1 prdx1 prone radioprotective radiosensitivity radiotherapy reentrance ros sod2 untimely
Tagcloud (Difference) ?		abeta1 autophagic autophagosomes autophagy bcl2 beclin becn1 buildup digested elevation favor favoring flux hamper incompletely jnk1 jnk2 lc3 lysosomal mapk8 modifying monomers neuroblastoma oligomers phosphorylating profound sk turn vacuoles	3beta accelerated balanced catastrophe crypt cyclins cytochrome dysregulated exhibiting follicles fus1 gammah2ax gi gsk hair individualized irradiation maintaining nfkappab parp1 prdx1 prone radioprotective radiosensitivity radiotherapy reentrance ros sod2 untimely
Tagcloud (Intersection) ?