MAPK9 and CDC25B

Number of citations of the paper that reports this interaction (PMID 15629715)
99

Data Source:
BioGRID (enzymatic study)

		MAPK9	CDC25B
Gene Name		mitogen-activated protein kinase 9	cell division cycle 25B
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol	Spindle Pole Nucleoplasm Cytoplasm Centrosome Cytosol
	Molecular Function	JUN Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Mitogen-activated Protein Kinase Kinase Kinase Binding	Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Positive Regulation Of Protein Phosphorylation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Protein Targeting To Mitochondrion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Stress JNK Cascade JUN Phosphorylation Central Nervous System Development Response To Mechanical Stimulus Response To Toxic Substance Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cell Morphogenesis Involved In Differentiation Response To Amine Neuron Projection Development Positive Regulation Of Prostaglandin Biosynthetic Process Regulation Of Protein Ubiquitination Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Chemokine Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To UV TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Response To Drug Regulation Of Circadian Rhythm Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of JNK Cascade Response To Cadmium Ion Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Stress-activated MAPK Cascade Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Signaling Pathway	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Oocyte Maturation Protein Phosphorylation Mitotic Nuclear Division Female Meiosis I Positive Regulation Of Cell Proliferation Positive Regulation Of Cytokinesis Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Mitotic Cell Cycle Cell Division
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Innate Immune System TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Oxidative Stress Induced Senescence Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling MAPK targets/ Nuclear events mediated by MAP kinases	Cyclin A/B1 associated events during G2/M transition G2/M Transition S Phase Cyclin A:Cdk2-associated events at S phase entry Mitotic G2-G2/M phases Cyclin B2 mediated events Cell Cycle, Mitotic
Drugs			Double Oxidized Cysteine Cysteinesulfonic Acid Methyl Mercury Ion
Diseases
GWAS
Protein-Protein Interactions		70 interactors: ACP5 ARRB1 ARRB2 ATF2 ATF7 BAZ1B BCL2L11 C1orf94 CASP3 CCDC33 CDC25B CDC25C CEP44 CLU CTBP1 CTNNB1 CYHR1 DUSP16 DUSP19 DUSP4 EEF2K EFHC2 ELK1 ELK3 GRB2 H3F3A HDAC9 HSF1 IRS1 JDP2 JUN JUNB JUND KIAA1377 L3MBTL3 LMAN2 LNX1 MACF1 MAP2K4 MAP2K7 MAP3K1 MAP3K10 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAPK5 MAPKBP1 MEOX1 NCF1 NFATC3 NFATC4 PRKD1 RB1 RPS6KB1 SF3B4 SH3BP5 SHMT1 SMAD2 SMAD3 SMCO3 SSU72 TEX11 TOB1 TP53 TRAF2 TUSC2 WDR62 XPNPEP1 XPO7 ZBTB25	25 interactors: AR AURKA BRSK1 BRSK2 CDC14A CDK1 CDK2 CHEK1 CREBBP CSNK2A1 CSNK2B ESR1 FHL3 KAT2B MAPK14 MAPK9 MAPKAPK2 MELK PGR SFN YWHAB YWHAE YWHAH YWHAQ YWHAZ
Entrez ID		5601	994
HPRD ID		04206	00307
Ensembl ID		ENSG00000050748	ENSG00000101224
Uniprot IDs		P45984	B3KS38 B4DIG0 B4DRC3 G8JLH2 P30305 Q6MZW8
PDB IDs		3E7O 3NPC	1CWR 1CWS 1CWT 1QB0 1YM9 1YMD 1YMK 1YML 1YS0 2A2K 2IFD 2IFV 2UZQ 3FQT 3FQU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Response To Stress Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process MAPK Cascade Intracellular Signal Transduction Regulation Of Kinase Activity Apoptotic Process Regulation Of Protein Kinase Activity Signal Transduction By Phosphorylation Negative Regulation Of Cellular Metabolic Process Programmed Cell Death Cell Death Death Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of MAPK Cascade Positive Regulation Of Cellular Biosynthetic Process Developmental Process Regulation Of Cellular Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Neuron Death Positive Regulation Of Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Defense Response Cellular Metabolic Process Cellular Response To Stress Regulation Of Signaling Regulation Of Gene Expression Anatomical Structure Development Cell Differentiation Positive Regulation Of Phosphorylation Signal Transduction Toll-like Receptor 4 Signaling Pathway Immune System Process Transcription From RNA Polymerase II Promoter Regulation Of Catalytic Activity Regulation Of JUN Kinase Activity Signaling	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Cycle Intrinsic Apoptotic Signaling Pathway G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Mitochondrion Organization Apoptotic Signaling Pathway Apoptotic Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Transport Programmed Cell Death Cell Cycle Process Cell Death Death Multicellular Organismal Development Developmental Process System Development Signaling Anatomical Structure Development Regulation Of Apoptotic Process Cell Communication Phosphorylation Cellular Response To Stimulus Regulation Of Mitochondrion Organization Regulation Of Establishment Of Protein Localization Regulation Of Cell Death Positive Regulation Of Apoptotic Signaling Pathway Signal Transduction Phosphate-containing Compound Metabolic Process Protein Phosphorylation Cell Cycle Checkpoint Regulation Of Protein Localization Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Intracellular Signal Transduction DNA Damage Checkpoint Regulation Of Intracellular Transport Regulation Of Signal Transduction Cellular Response To Stress Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transport Mitotic Cell Cycle Regulation Of Cellular Localization Histone Phosphorylation G2 DNA Damage Checkpoint Response To Stimulus
Tagcloud ?		abeta1 autophagic autophagosomes autophagy bcl2 beclin becn1 buildup digested elevation favor favoring flux hamper incompletely jnk1 jnk2 lc3 lysosomal mapk8 modifying monomers neuroblastoma oligomers phosphorylating profound sk turn vacuoles	anticancer box constituent contrary elucidated exhibits forkhead foxm1 g2 garnered glioma gliomas inactivation m1 medicinal natural nevertheless oncogenic p21cip1 p27kip1 plumbagin plumbago quinonoid root sifoxm1 survivin transactivation transfection zeylanica
Tagcloud (Difference) ?		abeta1 autophagic autophagosomes autophagy bcl2 beclin becn1 buildup digested elevation favor favoring flux hamper incompletely jnk1 jnk2 lc3 lysosomal mapk8 modifying monomers neuroblastoma oligomers phosphorylating profound sk turn vacuoles	anticancer box constituent contrary elucidated exhibits forkhead foxm1 g2 garnered glioma gliomas inactivation m1 medicinal natural nevertheless oncogenic p21cip1 p27kip1 plumbagin plumbago quinonoid root sifoxm1 survivin transactivation transfection zeylanica
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