MAPK9 and NCSTN

Number of citations of the paper that reports this interaction (PubMedID 18667537)
50

Data Source:
BioGRID (enzymatic study)

		MAPK9	NCSTN
Description		mitogen-activated protein kinase 9	nicastrin
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Nuclear Speck Schaffer Collateral - CA1 Synapse	Golgi Membrane Lysosome Lysosomal Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Focal Adhesion Synaptic Vesicle Endosome Membrane Endomembrane System Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Azurophil Granule Membrane Sarcolemma Melanosome Presynaptic Membrane Extracellular Exosome Gamma-secretase Complex Synaptic Membrane Secretory Vesicle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Activity MAP Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Endopeptidase Activity Protein Binding Peptidase Activity Protein-macromolecule Adaptor Activity Aspartic Endopeptidase Activity, Intramembrane Cleaving ATPase Binding Endopeptidase Activator Activity Growth Factor Receptor Binding
	Biological Process	MAPK Cascade Protein Phosphorylation JNK Cascade Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Reactive Oxygen Species Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Regulation Of MRNA Stability Response To Cadmium Ion Rhythmic Process Modulation Of Chemical Synaptic Transmission MRNA Destabilization Protein Localization To Tricellular Tight Junction Positive Regulation Of Podosome Assembly Cellular Senescence Inflammatory Response To Wounding Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Apoptotic Signaling Pathway	Myeloid Cell Homeostasis Proteolysis Membrane Protein Ectodomain Proteolysis G Protein-coupled Dopamine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Notch Signaling Pathway Notch Receptor Processing Learning Or Memory Protein Processing Cerebellum Development Central Nervous System Myelination Adult Behavior Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation T Cell Proliferation Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Amyloid Precursor Protein Catabolic Process Amyloid-beta Metabolic Process Epithelial Cell Proliferation Neuron Apoptotic Process Cellular Response To Calcium Ion Regulation Of Long-term Synaptic Potentiation Short-term Synaptic Potentiation
Pathways		Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors Signaling by ALK fusions and activated point mutants	Nuclear signaling by ERBB4 Degradation of the extracellular matrix Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells Neutrophil degranulation NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation TGFBR3 PTM regulation
Drugs		Minocycline N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide Fostamatinib Halicin
Diseases			Acne inversa; Hidradenitis supprativa
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576)	Post bronchodilator FEV1 in COPD ( 26634245)
Interacting Genes		111 interacting genes: ACP5 AKT1 ARRB1 ARRB2 ATF2 ATF7 BCL2L1 BCL2L11 BTRC C1orf105 C1orf94 CASP3 CBLL2 CCDC33 CDC16 CDC25B CDC25C CEP126 CEP44 CLU CTBP1 CTNNB1 DCX DTX3 DUSP10 DUSP16 DUSP19 DUSP4 EEF2K EFHC2 EGFR ELK1 ELK3 ENKD1 FBXO7 GFAP GOLGA6A GRB2 GSC2 H3-3A HDAC9 HSF1 IHO1 IRS1 ITGB3BP JDP2 JUN JUNB JUND KLHL8 KPNA3 L3MBTL3 LHX3 LMAN2 LNX1 LNX2 LZTS1 MACF1 MAP2K4 MAP2K7 MAP3K1 MAP3K10 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAPK5 MAPKBP1 MAPT MCRS1 MED12L MEOX1 MLIP NCF1 NCSTN NFATC3 NFATC4 NHSL2 PAX5 PBX4 PICK1 POU6F2 PPARG PRKD1 PSEN1 RB1 RPS6KB1 RSPO4 SAXO1 SDCBP SF3B4 SH3BP5 SHMT1 SMAD2 SMAD3 SMCO3 SSU72 TCP10L TEX11 TOB1 TP53 TRAF2 TUSC2 WDR62 XPNPEP1 XPO7 ZBTB25 ZC2HC1C ZFTRAF1 ZNF138 ZNF559 ZNHIT1	11 interacting genes: ABL1 APH1A APH1B APP BACE1 MAPK9 PSEN1 PSEN2 PSENEN SPP1 TMED10
Entrez ID		5601	23385
HPRD ID		04206	05584
Ensembl ID		ENSG00000050748	ENSG00000162736
Uniprot IDs		D7R525 P45984	A0A8V8TPQ8 A0A8V8TPR8 B4DR82 Q92542
PDB IDs		3E7O 3NPC 7CML 7N8T 8ELC	2N7Q 2N7R 4UIS 5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC 6LQG 6LR4 7C9I 7D8X 7Y5T 7Y5X 7Y5Z 8IM7 8K8E 8KCO 8KCP 8KCS 8KCT 8KCU 8OQY 8OQZ 8X52 8X53 8X54
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Intracellular Signal Transduction MAPK Cascade Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Protein Kinase Binding Cellular Developmental Process Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway Nucleus Positive Regulation Of Transcription By RNA Polymerase II JNK Cascade JUN Kinase Binding Programmed Cell Death Cell Death Negative Regulation Of Apoptotic Process Cytoplasm Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Population Proliferation Regulation Of Macromolecule Metabolic Process Protein Binding Negative Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process	Gamma-secretase Complex Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process Amyloid-beta Metabolic Process Amyloid Precursor Protein Metabolic Process Notch Receptor Processing Membrane Protein Proteolysis Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Protein Processing Protein Maturation Membrane Protein Intracellular Domain Proteolysis Synaptic Membrane Enzyme Binding Positive Regulation Of Proteolysis Endopeptidase Activator Activity Modulation Of Chemical Synaptic Transmission Golgi Apparatus Protein Metabolic Process Endoplasmic Reticulum Early Endosome Presynaptic Membrane Synaptic Vesicle Golgi Membrane Astrocyte Activation Involved In Immune Response Neuron Projection Organization Plasma Membrane Regulation Of Proteolysis Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Cellular Response To Amyloid-beta Negative Regulation Of Axonogenesis Aspartic Endopeptidase Activity, Intramembrane Cleaving Response To Amyloid-beta Cell Surface Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Cytokine Production Cellular Response To Manganese Ion Positive Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Learning Or Memory Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Transport Neuron Projection Maintenance Endoplasmic Reticulum Membrane Endosome Membrane Signal Transduction
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?