PI4KB and NCS1

Number of citations of the paper that reports this interaction (PMID 11526106)
37

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		PI4KB	NCS1
Gene Name		phosphatidylinositol 4-kinase, catalytic, beta	neuronal calcium sensor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Mitochondrial Outer Membrane Endosome Cytosol Plasma Membrane Rough Endoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Cell Junction Axon Dendrite Dense Core Granule Golgi Cisterna Membrane Intracellular Membrane-bounded Organelle Postsynaptic Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	1-phosphatidylinositol 4-kinase Activity Protein Binding ATP Binding	Magnesium Ion Binding Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Protein Kinase Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Receptor-mediated Endocytosis Signal Transduction Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling	Regulation Of Neuron Projection Development Positive Regulation Of Exocytosis Phosphatidylinositol-mediated Signaling Calcium Ion Transmembrane Transport
Pathways		Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Phospholipid metabolism PI Metabolism
Drugs
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033)
Protein-Protein Interactions		4 interactors: NCS1 YWHAB YWHAG YWHAQ	9 interactors: ADRBK1 DRD2 DRD3 DRD5 DTX2 IL1RAPL1 KCND2 NBL1 PI4KB
Entrez ID		5298	23413
HPRD ID		11805	04500
Ensembl ID		ENSG00000143393	ENSG00000107130
Uniprot IDs		Q9UBF8	P62166
PDB IDs			1G8I 2LCP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Positive Regulation Of Transport Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Localization Positive Regulation Of Intracellular Transport Apoptotic Signaling Pathway Positive Regulation Of Organelle Organization Protein Targeting Regulation Of Intracellular Transport Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Establishment Of Protein Localization Nervous System Development Regulation Of Protein Localization Membrane Organization Intracellular Protein Transport Regulation Of Organelle Organization Apoptotic Process Programmed Cell Death Cell Death Death Cellular Response To Insulin Stimulus Positive Regulation Of Signal Transduction Cellular Protein Localization Protein Transport Response To Insulin Regulation Of Apoptotic Process Establishment Of Protein Localization Negative Regulation Of Protein Dephosphorylation System Development Cellular Response To Peptide Hormone Stimulus Intracellular Transport Regulation Of Cell Death Generation Of Neurons Cellular Response To Peptide Neurogenesis Multicellular Organismal Development Anatomical Structure Development Transport Protein Localization Response To Peptide Hormone Establishment Of Localization In Cell	Synaptic Transmission, Dopaminergic Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Dopamine Receptor Signaling Pathway Response To Amphetamine Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Dopamine Receptor Signaling Pathway Receptor Internalization Negative Regulation Of Blood Pressure Response To Cocaine Response To Amine Regulation Of Adenylate Cyclase Activity Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Cyclase Activity Neuron-neuron Synaptic Transmission Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway Receptor Metabolic Process Associative Learning Blood Circulation Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of CAMP Biosynthetic Process Response To Ammonium Ion Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Receptor-mediated Endocytosis Regulation Of CAMP Metabolic Process Positive Regulation Of Renal Sodium Excretion Response To Histamine G-protein Coupled Receptor Internalization Arachidonic Acid Secretion Behavioral Response To Cocaine Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Ion Transmembrane Transport Regulation Of Neurotransmitter Uptake Prepulse Inhibition Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Learning Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Synaptic Transmission, Dopaminergic G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Alkaloid Negative Regulation Of Secretion By Cell Regulation Of Renal Sodium Excretion Negative Regulation Of Adenylate Cyclase Activity Regulation Of Dopamine Secretion Negative Regulation Of Lyase Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Signaling Regulation Of Excretion
Tagcloud ?		1q address akt3 amplified cascades copy cosmic encodes encoding enzymes evident extending iiibeta isozyme issue localize mutational neu numerically oncogenes phosphatidylinositol phosphoinositide pi3kc2b pip5k1a quartet resource signalling structurally uncommon	17a 17f 1bb augment bet bipolarization car cars cd161 cd28 cd3zeta costimulator exception expand generates hematologic icos il1r nonlymphoid notable note persist persistence redirected redirection rorc th1 th17 transferred
Tagcloud (Difference) ?		1q address akt3 amplified cascades copy cosmic encodes encoding enzymes evident extending iiibeta isozyme issue localize mutational neu numerically oncogenes phosphatidylinositol phosphoinositide pi3kc2b pip5k1a quartet resource signalling structurally uncommon	17a 17f 1bb augment bet bipolarization car cars cd161 cd28 cd3zeta costimulator exception expand generates hematologic icos il1r nonlymphoid notable note persist persistence redirected redirection rorc th1 th17 transferred
Tagcloud (Intersection) ?