EXOSC7 and EXOSC2

Number of citations of the paper that reports this interaction (PMID 11719186)
268

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (in vivo, two hybrid)

		EXOSC7	EXOSC2
Gene Name		exosome component 7	exosome component 2
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Gene Ontology Annotations	Cellular Component	Exosome (RNase Complex) Nucleus Nucleolus Cytosol	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding 7S RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing RNA Catabolic Process Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Gene Expression Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: APP DIS3 DXO EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC8 EXOSC9 IP6K1 MPP6 SKIV2L2	16 interactors: DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 GALNT13 KHSRP MPP6 MRPL48 RNF8 SKIV2L2 ST6GALNAC1 UPF1 ZNF408
Entrez ID		23016	23404
HPRD ID		09401	03758
Ensembl ID		ENSG00000075914	ENSG00000130713
Uniprot IDs		B2RDZ9 Q15024	B3KQW2 Q13868
PDB IDs		2NN6	2NN6
Enriched GO Terms of Interacting Partners?		RRNA Processing RRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Ribonucleoprotein Complex Biogenesis MRNA Metabolic Process NcRNA Metabolic Process Nuclear MRNA Surveillance RNA Surveillance Aromatic Compound Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Maturation Of 5.8S RRNA Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis RRNA Catabolic Process RNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Catabolic Process Nucleobase-containing Compound Metabolic Process DNA Deamination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Gene Expression Cellular Metabolic Process Histone MRNA Catabolic Process Intracellular MRNA Localization DNA Modification Positive Regulation Of Cell Growth Histone MRNA Metabolic Process RNA Processing Positive Regulation Of Growth Regulation Of Growth Metabolic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Regulation Of Cell Growth Nuclear Polyadenylation-dependent TRNA Catabolic Process Synaptic Growth At Neuromuscular Junction Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing RNA 3'-end Processing	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Processing RRNA Metabolic Process MRNA Catabolic Process RNA Catabolic Process Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process Ribonucleoprotein Complex Biogenesis MRNA Metabolic Process Aromatic Compound Catabolic Process NcRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis DNA Deamination Catabolic Process RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Maturation Of 5.8S RRNA Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Nitrogen Compound Metabolic Process Nuclear MRNA Surveillance RNA Surveillance Histone MRNA Catabolic Process DNA Modification RRNA Catabolic Process Histone MRNA Metabolic Process Isotype Switching Metabolic Process Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response DNA Metabolic Process Immunoglobulin Production Histone H2A K63-linked Ubiquitination Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Positive Regulation Of Cell Growth MRNA Transport RNA Transport RNA Localization Leukocyte Activation Involved In Immune Response
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