EXOSC7 and KIF24

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		EXOSC7	KIF24
Description		exosome component 7	kinesin family member 24
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Microtubule Protein-containing Complex
	Molecular Function	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Identical Protein Binding
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway	Microtubule-based Movement Microtubule Depolymerization Cell Projection Organization Cilium Assembly Negative Regulation Of Cilium Assembly
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	Anchoring of the basal body to the plasma membrane
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862)	Adolescent idiopathic scoliosis ( 31417091) Fruit consumption ( 32066663)
Interacting Genes		46 interacting genes: ALG13 APP C1orf35 CCDC59 DIS3 DMRTB1 DPYSL2 DXO EHMT2 EIF4ENIF1 ESRRG ESS2 EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC8 EXOSC9 HOOK1 IP6K1 KIF24 KRT31 LARP4 MIF MTREX PALS2 PRC1 PRPF6 PRRC2B PTEN RALYL RBM22 RBM7 RBPMS RPA2 RPL21 SNRNP48 SNW1 SUPT5H TFIP11 THOC1 UBE2K UNKL VIM	14 interacting genes: AP1M1 CSNK2A1 CWF19L2 EXOSC7 HSF2BP KAT5 LNX1 MYO15B NXF1 PRKAA2 PRPF6 RANBP3L RNF8 SYT6
Entrez ID		23016	347240
HPRD ID		09401	12963
Ensembl ID		ENSG00000075914	ENSG00000186638
Uniprot IDs		B2RDZ9 Q15024	Q5T7B8
PDB IDs		2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance RNA Exonuclease Activity Nuclear RNA Surveillance RNA Binding RNA Surveillance U4 SnRNA 3'-end Processing SnRNA Metabolic Process RNA Catabolic Process MRNA Metabolic Process RRNA Catabolic Process RNA Processing Poly(A)-dependent SnoRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process RNA Metabolic Process SnRNA 3'-end Processing MRNA Catabolic Process Nucleobase-containing Compound Catabolic Process 3'-5'-RNA Exonuclease Activity RRNA Processing SnRNA Processing Exoribonuclease Complex Sno(s)RNA Metabolic Process RRNA Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Nucleic Acid Metabolic Process RNA 3'-end Processing Nucleoplasm RRNA 3'-end Processing TRNA Decay Nucleobase-containing Compound Metabolic Process Nucleus Macromolecule Metabolic Process Catalytic Step 2 Spliceosome SnRNA Catabolic Process CUT Catabolic Process Macromolecule Catabolic Process Spliceosomal Complex DNA Deamination RNA Splicing Nucleolus Negative Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Maturation Of 5.8S RRNA	Protein Localization To Site Of Double-strand Break Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Aggrephagy Lipid Droplet Disassembly Double-strand Break Repair Phosphatidylethanolamine Biosynthetic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Aggrephagy Protein Localization To Vacuole Protein Targeting To Vacuole Involved In Autophagy Positive Regulation Of Macroautophagy Protein Localization To Chromosome Sperm DNA Condensation Phosphatidylcholine Biosynthetic Process Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Intracellular Protein Localization Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Signal Transduction In Response To DNA Damage Protein K6-linked Ubiquitination Phosphatidylethanolamine Metabolic Process DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Autophagy Regulation Of Macroautophagy Nucleic Acid Metabolic Process Negative Regulation Of Double-strand Break Repair Lipid Droplet Organization Negative Regulation Of DNA Repair DNA Repair Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Myoblast Differentiation Negative Regulation Of Translational Initiation Negative Regulation Of DNA Recombination Protein Targeting To Vacuole Regulation Of DNA Repair Intracellular Protein Transport Cellular Response To Glucose Starvation Histone H2AK5 Acetyltransferase Activity DNA Recombination Macromolecule Catabolic Process Nucleoplasm Establishment Of Protein Localization To Vacuole Protein Transport MRNA Metabolic Process Cellular Response To Glucose Stimulus Phosphatidylcholine Metabolic Process Protein Localization To Organelle Autophagy Cellular Response To Carbohydrate Stimulus [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
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