EXOSC7 and SNRNP48

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		EXOSC7	SNRNP48
Description		exosome component 7	small nuclear ribonucleoprotein U11/U12 subunit 48
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex	Nucleus Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex Cytosol
	Molecular Function	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway	MRNA Processing RNA Splicing
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay	mRNA Splicing - Minor Pathway
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862)	BMI x environmental factors (excluding physical activity) interaction ( 33654129) BMI x environmental factors (including physical activity) interaction ( 33654129) Height ( 31562340) Obesity-related traits ( 23251661)
Interacting Genes		46 interacting genes: ALG13 APP C1orf35 CCDC59 DIS3 DMRTB1 DPYSL2 DXO EHMT2 EIF4ENIF1 ESRRG ESS2 EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC8 EXOSC9 HOOK1 IP6K1 KIF24 KRT31 LARP4 MIF MTREX PALS2 PRC1 PRPF6 PRRC2B PTEN RALYL RBM22 RBM7 RBPMS RPA2 RPL21 SNRNP48 SNW1 SUPT5H TFIP11 THOC1 UBE2K UNKL VIM	14 interacting genes: CDCA7L ENKD1 EXOSC7 GPX4 GRN HUNK LUC7L2 MRPS27 PRPF6 SRSF8 SUPT5H TFIP11 UBASH3A UTP14A
Entrez ID		23016	154007
HPRD ID		09401	12858
Ensembl ID		ENSG00000075914	ENSG00000168566
Uniprot IDs		B2RDZ9 Q15024	Q6IEG0
PDB IDs		2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P	2VY4 2VY5 8R7N 8Y6O 9GBW 9GC0 9GCL
Enriched GO Terms of Interacting Partners?		Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance RNA Exonuclease Activity Nuclear RNA Surveillance RNA Binding RNA Surveillance U4 SnRNA 3'-end Processing SnRNA Metabolic Process RNA Catabolic Process MRNA Metabolic Process RRNA Catabolic Process RNA Processing Poly(A)-dependent SnoRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process RNA Metabolic Process SnRNA 3'-end Processing MRNA Catabolic Process Nucleobase-containing Compound Catabolic Process 3'-5'-RNA Exonuclease Activity RRNA Processing SnRNA Processing Exoribonuclease Complex Sno(s)RNA Metabolic Process RRNA Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Nucleic Acid Metabolic Process RNA 3'-end Processing Nucleoplasm RRNA 3'-end Processing TRNA Decay Nucleobase-containing Compound Metabolic Process Nucleus Macromolecule Metabolic Process Catalytic Step 2 Spliceosome SnRNA Catabolic Process CUT Catabolic Process Macromolecule Catabolic Process Spliceosomal Complex DNA Deamination RNA Splicing Nucleolus Negative Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Maturation Of 5.8S RRNA	RNA Binding Nuclear Speck
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