EXOSC7 and IP6K1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EXOSC7	IP6K1
Gene Name		exosome component 7	inositol hexakisphosphate kinase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Exosome (RNase Complex) Nucleus Nucleolus Cytosol	Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding	Inositol Hexakisphosphate 5-kinase Activity ATP Binding Inositol-1,4,5-trisphosphate 3-kinase Activity Inositol Hexakisphosphate 1-kinase Activity Inositol Hexakisphosphate 3-kinase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing RNA Catabolic Process Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Synthesis of IPs in the nucleus Synthesis of pyrophosphates in the cytosol Inositol phosphate metabolism
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		14 interactors: APP DIS3 DXO EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC8 EXOSC9 IP6K1 MPP6 SKIV2L2	6 interactors: CACNA1A COPS2 DDB1 EXOSC7 GPS1 RAB3IL1
Entrez ID		23016	9807
HPRD ID		09401	07379
Ensembl ID		ENSG00000075914	ENSG00000176095
Uniprot IDs		B2RDZ9 Q15024	Q92551
PDB IDs		2NN6
Enriched GO Terms of Interacting Partners?		RRNA Processing RRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Ribonucleoprotein Complex Biogenesis MRNA Metabolic Process NcRNA Metabolic Process Nuclear MRNA Surveillance RNA Surveillance Aromatic Compound Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Maturation Of 5.8S RRNA Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis RRNA Catabolic Process RNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Catabolic Process Nucleobase-containing Compound Metabolic Process DNA Deamination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Gene Expression Cellular Metabolic Process Histone MRNA Catabolic Process Intracellular MRNA Localization DNA Modification Positive Regulation Of Cell Growth Histone MRNA Metabolic Process RNA Processing Positive Regulation Of Growth Regulation Of Growth Metabolic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Regulation Of Cell Growth Nuclear Polyadenylation-dependent TRNA Catabolic Process Synaptic Growth At Neuromuscular Junction Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing RNA 3'-end Processing	Cullin Deneddylation Protein Deneddylation Cerebellar Molecular Layer Development Protein Modification By Small Protein Removal Vestibular Nucleus Development Positive Regulation By Virus Of Viral Protein Levels In Host Cell Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Gamma-aminobutyric Acid Secretion Regulation Of Acetylcholine Secretion, Neurotransmission Rhythmic Synaptic Transmission UV-damage Excision Repair Positive Regulation Of Viral Release From Host Cell Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Negative Regulation Of Hormone Biosynthetic Process Pons Development Histone H2A Monoubiquitination Cerebellar Purkinje Cell Differentiation Histone H2A Ubiquitination Cerebellar Purkinje Cell Layer Morphogenesis Nucleotide-excision Repair, DNA Damage Removal Aromatic Compound Catabolic Process Histone Monoubiquitination Reflex Positive Regulation Of Viral Genome Replication Regulation Of Viral Release From Host Cell Behavioral Response To Pain Neuromuscular Synaptic Transmission
Tagcloud ?			2c acetyl adapt begun conversely cues demethylase depend dissociation epigenetic epigenetically fundamental h3k9 h3k9me3 hexakisphosphate influences inositol ip7 jmjd2c jumonji knockout lysine modifications pyrophosphate pyrophosphates repression rnai translates trimethyl
Tagcloud (Difference) ?			2c acetyl adapt begun conversely cues demethylase depend dissociation epigenetic epigenetically fundamental h3k9 h3k9me3 hexakisphosphate influences inositol ip7 jmjd2c jumonji knockout lysine modifications pyrophosphate pyrophosphates repression rnai translates trimethyl
Tagcloud (Intersection) ?