EXOSC7 and EXOSC9

Number of citations of the paper that reports this interaction (PMID 11719186)
268

Data Source:
HPRD (in vivo, two hybrid)

		EXOSC7	EXOSC9
Gene Name		exosome component 7	exosome component 9
Image
Gene Ontology Annotations	Cellular Component	Exosome (RNase Complex) Nucleus Nucleolus Cytosol	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding AU-rich Element Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing RNA Catabolic Process Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process RRNA Processing Immune Response Gene Expression Positive Regulation Of Cell Growth Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: APP DIS3 DXO EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC8 EXOSC9 IP6K1 MPP6 SKIV2L2	17 interactors: CHMP4B CSNK2A1 DDX39A DDX39B DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 MPP6 SKIV2L2 UBE2I ZDHHC17
Entrez ID		23016	5393
HPRD ID		09401	07315
Ensembl ID		ENSG00000075914	ENSG00000123737
Uniprot IDs		B2RDZ9 Q15024	B4DXG8 Q06265
PDB IDs		2NN6	2NN6
Enriched GO Terms of Interacting Partners?		RRNA Processing RRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Ribonucleoprotein Complex Biogenesis MRNA Metabolic Process NcRNA Metabolic Process Nuclear MRNA Surveillance RNA Surveillance Aromatic Compound Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Maturation Of 5.8S RRNA Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis RRNA Catabolic Process RNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Catabolic Process Nucleobase-containing Compound Metabolic Process DNA Deamination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Gene Expression Cellular Metabolic Process Histone MRNA Catabolic Process Intracellular MRNA Localization DNA Modification Positive Regulation Of Cell Growth Histone MRNA Metabolic Process RNA Processing Positive Regulation Of Growth Regulation Of Growth Metabolic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Regulation Of Cell Growth Nuclear Polyadenylation-dependent TRNA Catabolic Process Synaptic Growth At Neuromuscular Junction Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing RNA 3'-end Processing	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Processing RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Ribosome Biogenesis Ribonucleoprotein Complex Biogenesis MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process NcRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Maturation Of 5.8S RRNA Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process DNA Deamination RNA Phosphodiester Bond Hydrolysis RNA Metabolic Process CUT Catabolic Process Catabolic Process Nuclear MRNA Surveillance Gene Expression RNA Surveillance Nucleobase-containing Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis RRNA Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Modification Nitrogen Compound Metabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Cellular Metabolic Process TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Localization SnoRNA Metabolic Process RRNA 3'-end Processing Intracellular MRNA Localization Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA Processing Positive Regulation Of Cell Growth Metabolic Process Isotype Switching
Tagcloud ?			balance compartment degradation differentiation done enriched epidermal exosome grhl3 loss maintain maintaining maintains maintenance mammalian necessary pm premature prevent prevents progenitor proliferative promotes regulating renewal reside retain transcript understood
Tagcloud (Difference) ?			balance compartment degradation differentiation done enriched epidermal exosome grhl3 loss maintain maintaining maintains maintenance mammalian necessary pm premature prevent prevents progenitor proliferative promotes regulating renewal reside retain transcript understood
Tagcloud (Intersection) ?