UNC13B and STX1B

Number of citations of the paper that reports this interaction (PubMedID 8999968)
0

Data Source:
BioGRID (two hybrid, biochemical)

		UNC13B	STX1B
Description		unc-13 homolog B	syntaxin 1B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Synaptic Vesicle Membrane Neuromuscular Junction Presynaptic Membrane Terminal Bouton Synapse Presynaptic Active Zone	Nucleus Nuclear Lamina Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Endomembrane System Membrane Axon SNARE Complex Neuromuscular Junction Presynaptic Active Zone Membrane Presynapse
	Molecular Function	Calcium Ion Binding Protein Binding Calmodulin Binding Phospholipid Binding Zinc Ion Binding Syntaxin-1 Binding Diacylglycerol Binding GTP-dependent Protein Binding Small GTPase Binding Metal Ion Binding	SNARE Binding Signaling Receptor Binding SNAP Receptor Activity Protein Binding Protein Kinase Binding
	Biological Process	Exocytosis Chemical Synaptic Transmission Positive Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Transmission, Glutamatergic Positive Regulation Of Apoptotic Process Positive Regulation Of Protein Secretion Acrosomal Vesicle Exocytosis Dense Core Granule Priming Cellular Response To Glucose Stimulus Positive Regulation Of Inhibitory Postsynaptic Potential Neuronal Dense Core Vesicle Exocytosis	Positive Regulation Of Neurotransmitter Secretion Neurotransmitter Transport Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Regulation Of Gene Expression Regulation Of Synaptic Vesicle Priming Negative Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Docking Calcium Ion-regulated Exocytosis Of Neurotransmitter Regulation Of Synaptic Activity Spontaneous Neurotransmitter Secretion Negative Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Spontaneous Neurotransmitter Secretion Negative Regulation Of Macropinocytosis Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle	Toxicity of botulinum toxin type C (botC) LGI-ADAM interactions
Drugs
Diseases
GWAS		Parkinson's disease ( 21812969)	Adult body size ( 32376654) Body mass index ( 31453325) Body mass index variance ( 31453325) Dementia with Lewy bodies ( 29263008) Hip circumference ( 31453325) Hip circumference variance ( 31453325) Juvenile myoclonic epilepsy ( 30531953) Low density lipoprotein cholesterol levels ( 32154731) Parkinson's disease ( 25064009 32201043) Psoriasis ( 25574825) Response to metformin (IC50) ( 28173075) Waist circumference ( 31453325) Waist circumference variance ( 31453325) Walking pace ( 33128006)
Interacting Genes		12 interacting genes: CFAP298 CLK1 DOC2A DOC2B PDCL2 RIMS1 RPH3AL SPTBN2 STX1A STX1B STX2 TOE1	30 interacting genes: ABHD16A ACBD5 AQP6 BET1 EBP ERGIC3 FAM161B FAM209A FAM81A FBXO28 FGA GJA8 GPR152 KCNN4 MMGT1 NAPB SNAP23 SNAP29 SNAP47 SNCA STX2 STX4 STXBP1 TMEM167B TXLNA UBE2I UNC13B VAMP1 VAMP2 VAMP5
Entrez ID		10497	112755
HPRD ID		05785	18126
Ensembl ID		ENSG00000198722	ENSG00000099365
Uniprot IDs		A0A1B0GUS7 A0A1B0GVW8 O14795	P61266
PDB IDs
Enriched GO Terms of Interacting Partners?		Exocytosis Synaptic Vesicle Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Secretion By Cell Vesicle-mediated Transport In Synapse Calcium-ion Regulated Exocytosis Neurotransmitter Transport Regulated Exocytosis Spontaneous Neurotransmitter Secretion Regulation Of Calcium Ion-dependent Exocytosis Secretion Regulation Of Regulated Secretory Pathway SNARE Complex Positive Regulation Of Regulated Secretory Pathway Synaptic Vesicle Docking Signal Release Vesicle Docking Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Exocytosis Vesicle-mediated Transport Organelle Localization By Membrane Tethering Positive Regulation Of Exocytosis Positive Regulation Of Vesicle Fusion Membrane Docking Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Vesicle-mediated Transport Presynaptic Active Zone Membrane Regulation Of Secretion By Cell Positive Regulation Of Secretion By Cell Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Secretion Regulation Of Secretion Regulation Of Vesicle Fusion SNAP Receptor Activity Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Membrane Fusion Modulation Of Excitatory Postsynaptic Potential SNARE Binding Presynapse Calcium Ion-regulated Exocytosis Of Neurotransmitter Intracellular Protein Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Establishment Of Localization In Cell Regulation Of Synaptic Vesicle Priming Regulation Of Neurotransmitter Secretion Vesicle Fusion Organelle Membrane Fusion Synaptic Vesicle Membrane Organization	SNAP Receptor Activity SNARE Complex Syntaxin Binding Exocytosis Synaptic Vesicle Priming Vesicle-mediated Transport Vesicle Fusion Organelle Membrane Fusion SNARE Complex Assembly Secretion Secretion By Cell Organelle Fusion Membrane Fusion Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Vesicle Organization Membrane Organization Synaptic Vesicle Membrane Organization SNARE Binding Organelle Localization By Membrane Tethering Membrane Docking Regulation Of Synaptic Vesicle Priming Establishment Of Localization In Cell Membrane Protein-containing Complex Organization Syntaxin-1 Binding Vesicle Docking Positive Regulation Of Protein Transport Protein-containing Complex Assembly Positive Regulation Of Protein Localization Positive Regulation Of Secretion By Cell Positive Regulation Of Exocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Regulation Of Exocytosis Positive Regulation Of Secretion Positive Regulation Of Establishment Of Protein Localization Synaptic Vesicle Exocytosis Calcium-ion Regulated Exocytosis Transport Vesicle Cellular Component Assembly Regulated Exocytosis Cornified Envelope Assembly Neuronal Dense Core Vesicle Exocytosis Cellular Localization Presynapse Regulation Of Secretion By Cell Establishment Of Protein Localization Dense Core Granule Exocytosis Positive Regulation Of Transport Synaptic Vesicle Membrane
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