UNC13B and TOE1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		UNC13B	TOE1
Gene Name		unc-13 homolog B (C. elegans)	target of EGR1, member 1 (nuclear)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Junction Neuromuscular Junction Terminal Bouton Presynaptic Active Zone	Nucleus Nucleoplasm Nucleolus Nuclear Speck
	Molecular Function	Signal Transducer Activity Receptor Activity Protein Binding Diacylglycerol Binding Metal Ion Binding	Nucleic Acid Binding Protein Binding Metal Ion Binding
	Biological Process	Apoptotic Process Signal Transduction Synaptic Transmission Neurotransmitter Secretion Neuromuscular Junction Development Excretion Positive Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Transmission, Glutamatergic Intracellular Signal Transduction Regulation Of Short-term Neuronal Synaptic Plasticity Innervation Positive Regulation Of Inhibitory Postsynaptic Membrane Potential
Pathways		Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Parkinson's disease ( 21812969)
Protein-Protein Interactions		9 interactors: DOC2A DOC2B RIMS1 RPH3AL SPTBN2 STX1A STX1B STX2 TOE1	25 interactors: ABCF3 AGGF1 AP2A1 APLP1 CA12 HNRNPF IK IL7R LSM4 PPP1CA PRCC RAB40C RBM39 RBM8A RPS3A SF3B2 SF3B3 SH3GL3 SQSTM1 SRSF6 SUMO1 U2AF1 UNC13B WDR77 WDR83
Entrez ID		10497	114034
HPRD ID		05785	18212
Ensembl ID		ENSG00000198722	ENSG00000132773
Uniprot IDs		B1AM27 F8W8M9 O14795 Q4LE73	B4DEM6 Q96GM8
PDB IDs			2FC6
Enriched GO Terms of Interacting Partners?		Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Synaptic Vesicle Exocytosis Neurotransmitter Transport Secretion By Cell Secretion Synaptic Vesicle Transport Exocytosis Regulation Of Exocytosis Establishment Of Vesicle Localization Vesicle Localization Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Secretion Vesicle-mediated Transport Establishment Of Organelle Localization Regulation Of Vesicle-mediated Transport Membrane Fusion Cell-cell Signaling Organelle Localization Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Cellular Localization Establishment Of Localization In Cell Positive Regulation Of Membrane Potential Calcium Ion-dependent Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Synaptic Transmission Vesicle Fusion Cellular Localization Regulation Of Neurotransmitter Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Organelle Fusion Positive Regulation Of Secretion Vesicle Docking Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Calcium Ion-dependent Exocytosis Of Neurotransmitter Membrane Docking Transport Intracellular Protein Transport Membrane Depolarization Protein Localization Positive Regulation Of Neurotransmitter Secretion Glutamate Secretion Cellular Protein Localization Protein Transport Vesicle Organization Establishment Of Protein Localization Intracellular Transport Regulation Of Synaptic Vesicle Exocytosis	MRNA Metabolic Process RNA Processing MRNA Processing RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA 3'-end Processing RNA 3'-end Processing RNA Metabolic Process Termination Of RNA Polymerase II Transcription Gene Expression Nucleobase-containing Compound Metabolic Process MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Nuclear Export MRNA Transport Nitrogen Compound Metabolic Process RNA Transport Regulation Of Alternative MRNA Splicing, Via Spliceosome Cellular Localization Nuclear-transcribed MRNA Catabolic Process RNA Localization MRNA Catabolic Process Cytoplasmic Transport Establishment Of Localization In Cell Intracellular Transport RNA Catabolic Process Positive Regulation Of Synaptic Vesicle Priming Positive Regulation Of Synaptic Vesicle Exocytosis Interleukin-7-mediated Signaling Pathway Regulation Of MRNA Splicing, Via Spliceosome Nucleocytoplasmic Transport Cellular Metabolic Process Nuclear Transport Negative Regulation Of Hyaluronan Biosynthetic Process Cellular Response To Norepinephrine Stimulus Regulation Of Epithelial Cell Proliferation Regulation Of MRNA Processing PML Body Organization Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Negative Regulation Of T Cell Mediated Cytotoxicity Cellular Process
Tagcloud ?		accn1 ago arises cgg description disturbed eef1a2 fmr1 fmrp fragile gabrd hes1 inherited intelligence interactive lending lymphoblastoid lymphoblasts males microarrays morphogenesis neurodevelopment overrepresentation ppp1r9b retardation syndrome transcriptome trinucleotide untranslated
Tagcloud (Difference) ?		accn1 ago arises cgg description disturbed eef1a2 fmr1 fmrp fragile gabrd hes1 inherited intelligence interactive lending lymphoblastoid lymphoblasts males microarrays morphogenesis neurodevelopment overrepresentation ppp1r9b retardation syndrome transcriptome trinucleotide untranslated
Tagcloud (Intersection) ?