UNC13B and TOE1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		UNC13B	TOE1
Description		unc-13 homolog B	target of EGR1, exonuclease
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Synaptic Vesicle Membrane Neuromuscular Junction Presynaptic Membrane Terminal Bouton Synapse Presynaptic Active Zone	Nucleus Nucleoplasm Nucleolus Cytoplasm Cajal Body Nuclear Body Nuclear Speck
	Molecular Function	Calcium Ion Binding Protein Binding Calmodulin Binding Phospholipid Binding Zinc Ion Binding Syntaxin-1 Binding Diacylglycerol Binding GTP-dependent Protein Binding Small GTPase Binding Metal Ion Binding	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding Poly(A)-specific Ribonuclease Activity Protein Binding Zinc Ion Binding SnRNA Binding Metal Ion Binding
	Biological Process	Exocytosis Chemical Synaptic Transmission Positive Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Transmission, Glutamatergic Positive Regulation Of Apoptotic Process Positive Regulation Of Protein Secretion Acrosomal Vesicle Exocytosis Dense Core Granule Priming Cellular Response To Glucose Stimulus Positive Regulation Of Inhibitory Postsynaptic Potential Neuronal Dense Core Vesicle Exocytosis	RNA Metabolic Process SnRNA 3'-end Processing
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle
Drugs
Diseases
GWAS		Parkinson's disease ( 21812969)
Interacting Genes		12 interacting genes: CFAP298 CLK1 DOC2A DOC2B PDCL2 RIMS1 RPH3AL SPTBN2 STX1A STX1B STX2 TOE1	27 interacting genes: ABCF3 AGGF1 ANXA1 AP2A1 APLP1 CA12 HNRNPF IK IL7R LSM4 OGT PPP1CA PRCC RAB40C RBM39 RBM8A RPS3A SF3B2 SF3B3 SH3GL3 SQSTM1 SRSF6 SUMO1 U2AF1 UNC13B WDR77 WDR83
Entrez ID		10497	114034
HPRD ID		05785	18212
Ensembl ID		ENSG00000198722	ENSG00000132773
Uniprot IDs		A0A1B0GUS7 A0A1B0GVW8 O14795	B4DP23 Q96GM8
PDB IDs			2FC6
Enriched GO Terms of Interacting Partners?		Exocytosis Synaptic Vesicle Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Secretion By Cell Vesicle-mediated Transport In Synapse Calcium-ion Regulated Exocytosis Neurotransmitter Transport Regulated Exocytosis Spontaneous Neurotransmitter Secretion Regulation Of Calcium Ion-dependent Exocytosis Secretion Regulation Of Regulated Secretory Pathway SNARE Complex Positive Regulation Of Regulated Secretory Pathway Synaptic Vesicle Docking Signal Release Vesicle Docking Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Exocytosis Vesicle-mediated Transport Organelle Localization By Membrane Tethering Positive Regulation Of Exocytosis Positive Regulation Of Vesicle Fusion Membrane Docking Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Vesicle-mediated Transport Presynaptic Active Zone Membrane Regulation Of Secretion By Cell Positive Regulation Of Secretion By Cell Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Secretion Regulation Of Secretion Regulation Of Vesicle Fusion SNAP Receptor Activity Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Membrane Fusion Modulation Of Excitatory Postsynaptic Potential SNARE Binding Presynapse Calcium Ion-regulated Exocytosis Of Neurotransmitter Intracellular Protein Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Establishment Of Localization In Cell Regulation Of Synaptic Vesicle Priming Regulation Of Neurotransmitter Secretion Vesicle Fusion Organelle Membrane Fusion Synaptic Vesicle Membrane Organization	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing Spliceosomal Complex MRNA Processing MRNA Metabolic Process Catalytic Step 2 Spliceosome RNA Metabolic Process Nucleoplasm Nuclear Speck Regulation Of RNA Splicing RNA Processing Nucleic Acid Metabolic Process Macromolecule Metabolic Process U2-type Precatalytic Spliceosome Nucleobase-containing Compound Metabolic Process Protein-RNA Complex Assembly Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome RS Domain Binding Regulation Of MRNA Processing Glutamatergic Synapse Cadherin Binding Involved In Cell-cell Adhesion RNA Binding Transition Metal Ion Binding U2-type Prespliceosome Assembly U12-type Spliceosomal Complex U2 SnRNP Membraneless Organelle Assembly U2-type Spliceosomal Complex Regulation Of Programmed Cell Death Alpha-2B Adrenergic Receptor Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Synaptic Vesicle Priming Oocyte Axis Specification
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