UNC13B and SPTBN2

Number of citations of the paper that reports this interaction (PMID 9704016)
14

Data Source:
HPRD (two hybrid)

		UNC13B	SPTBN2
Gene Name		unc-13 homolog B (C. elegans)	spectrin, beta, non-erythrocytic 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Junction Neuromuscular Junction Terminal Bouton Presynaptic Active Zone	Extracellular Space Cytoplasm Cytosol Spectrin Apical Plasma Membrane Cell Junction Neuronal Cell Body
	Molecular Function	Signal Transducer Activity Receptor Activity Protein Binding Diacylglycerol Binding Metal Ion Binding	Actin Binding Structural Constituent Of Cytoskeleton Phospholipid Binding
	Biological Process	Apoptotic Process Signal Transduction Synaptic Transmission Neurotransmitter Secretion Neuromuscular Junction Development Excretion Positive Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Transmission, Glutamatergic Intracellular Signal Transduction Regulation Of Short-term Neuronal Synaptic Plasticity Innervation Positive Regulation Of Inhibitory Postsynaptic Membrane Potential	Axon Guidance Synapse Assembly Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cerebellar Purkinje Cell Layer Morphogenesis Adult Behavior Multicellular Organism Growth Actin Filament Capping
Pathways		Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses	Interaction between L1 and Ankyrins Axon guidance MHC class II antigen presentation L1CAM interactions NCAM signaling for neurite out-growth Adaptive Immune System
Drugs
Diseases
GWAS		Parkinson's disease ( 21812969)	Bipolar disorder ( 21926972)
Protein-Protein Interactions		9 interactors: DOC2A DOC2B RIMS1 RPH3AL SPTBN2 STX1A STX1B STX2 TOE1	9 interactors: ACTA1 ACTB ACTR1A APC CELSR3 DCTN1 MINK1 SPTA1 UNC13B
Entrez ID		10497	6712
HPRD ID		05785	05404
Ensembl ID		ENSG00000198722	ENSG00000173898
Uniprot IDs		B1AM27 F8W8M9 O14795 Q4LE73	O15020
PDB IDs			1WJM 1WYQ
Enriched GO Terms of Interacting Partners?		Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Synaptic Vesicle Exocytosis Neurotransmitter Transport Secretion By Cell Secretion Synaptic Vesicle Transport Exocytosis Regulation Of Exocytosis Establishment Of Vesicle Localization Vesicle Localization Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Secretion Vesicle-mediated Transport Establishment Of Organelle Localization Regulation Of Vesicle-mediated Transport Membrane Fusion Cell-cell Signaling Organelle Localization Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Cellular Localization Establishment Of Localization In Cell Positive Regulation Of Membrane Potential Calcium Ion-dependent Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Synaptic Transmission Vesicle Fusion Cellular Localization Regulation Of Neurotransmitter Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Organelle Fusion Positive Regulation Of Secretion Vesicle Docking Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Calcium Ion-dependent Exocytosis Of Neurotransmitter Membrane Docking Transport Intracellular Protein Transport Membrane Depolarization Protein Localization Positive Regulation Of Neurotransmitter Secretion Glutamate Secretion Cellular Protein Localization Protein Transport Vesicle Organization Establishment Of Protein Localization Intracellular Transport Regulation Of Synaptic Vesicle Exocytosis	Organelle Organization Nervous System Development Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis System Development Neuron Development Cell Development Cell Morphogenesis Multicellular Organismal Development Anatomical Structure Development Neuron Differentiation Cell Projection Organization Axon Development Immune System Process Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Developmental Process Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Differentiation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Generation Of Neurons Neurogenesis Homotypic Cell-cell Adhesion Regulation Of Protein Complex Assembly T Cell Differentiation In Thymus Cellular Component Assembly Positive Regulation Of Synaptic Vesicle Priming Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cell Differentiation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Cytoskeleton Organization Negative Regulation Of Protein Complex Disassembly Cell Adhesion Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Regulation Of Protein Depolymerization Positive Regulation Of Synaptic Vesicle Exocytosis Skeletal Muscle Fiber Adaptation Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Locomotion Single Organismal Cell-cell Adhesion Axonogenesis G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Complex Disassembly Actin Cytoskeleton Organization Response To Stimulus Regulation Of Cell Adhesion Vesicle-mediated Transport
Tagcloud ?		accn1 ago arises cgg description disturbed eef1a2 fmr1 fmrp fragile gabrd hes1 inherited intelligence interactive lending lymphoblastoid lymphoblasts males microarrays morphogenesis neurodevelopment overrepresentation ppp1r9b retardation syndrome transcriptome trinucleotide untranslated
Tagcloud (Difference) ?		accn1 ago arises cgg description disturbed eef1a2 fmr1 fmrp fragile gabrd hes1 inherited intelligence interactive lending lymphoblastoid lymphoblasts males microarrays morphogenesis neurodevelopment overrepresentation ppp1r9b retardation syndrome transcriptome trinucleotide untranslated
Tagcloud (Intersection) ?