UNC13B and RIMS1

Number of citations of the paper that reports this interaction (PubMedID 12163476)
62

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		UNC13B	RIMS1
Description		unc-13 homolog B	regulating synaptic membrane exocytosis 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Synaptic Vesicle Membrane Neuromuscular Junction Presynaptic Membrane Terminal Bouton Synapse Presynaptic Active Zone	Cytosol Plasma Membrane Membrane Presynaptic Membrane Cell Projection Synapse Presynaptic Active Zone Presynaptic Active Zone Cytoplasmic Component
	Molecular Function	Calcium Ion Binding Protein Binding Calmodulin Binding Phospholipid Binding Zinc Ion Binding Syntaxin-1 Binding Diacylglycerol Binding GTP-dependent Protein Binding Small GTPase Binding Metal Ion Binding	RNA Binding Protein Binding Zinc Ion Binding GTPase Regulator Activity Small GTPase Binding Metal Ion Binding Structural Constituent Of Presynaptic Active Zone
	Biological Process	Exocytosis Chemical Synaptic Transmission Positive Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Transmission, Glutamatergic Positive Regulation Of Apoptotic Process Positive Regulation Of Protein Secretion Acrosomal Vesicle Exocytosis Dense Core Granule Priming Cellular Response To Glucose Stimulus Positive Regulation Of Inhibitory Postsynaptic Potential Neuronal Dense Core Vesicle Exocytosis	Neurotransmitter Transport Intracellular Protein Transport Exocytosis Visual Perception Positive Regulation Of Gene Expression Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Calcium-ion Regulated Exocytosis Cell Differentiation Regulated Exocytosis Secretion Regulation Of Neurotransmitter Secretion Maintenance Of Presynaptic Active Zone Structure Acrosomal Vesicle Exocytosis Membrane Fusion Protein-containing Complex Assembly Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation
Drugs
Diseases			Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Parkinson's disease ( 21812969)	Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 33263727 31043756) Chronotype ( 30696823) Cognitive performance ( 20125193) LDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Lung cancer ( 28604730) Lung cancer in never smokers ( 28604730) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278) Response to mTOR inhibitor (rapamycin) ( 24009623) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260 29483656 25056061) Squamous cell lung carcinoma ( 28604730) Total cholesterol levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Triglyceride levels ( 32203549)
Interacting Genes		12 interacting genes: CFAP298 CLK1 DOC2A DOC2B PDCL2 RIMS1 RPH3AL SPTBN2 STX1A STX1B STX2 TOE1	16 interacting genes: CACNA1B CACNA1C CAMK2A ERC1 ERC2 RAB10 RAB26 RAB27A RAB37 RAB3A RNF10 SNAP25 STX1A SYT1 UNC13B YWHAH
Entrez ID		10497	22999
HPRD ID		05785	09435
Ensembl ID		ENSG00000198722	ENSG00000079841
Uniprot IDs		A0A1B0GUS7 A0A1B0GVW8 O14795	B7Z7W2 B7Z9Z3 Q3ZCW0 Q86UR5
PDB IDs			2CSS
Enriched GO Terms of Interacting Partners?		Exocytosis Synaptic Vesicle Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Secretion By Cell Vesicle-mediated Transport In Synapse Calcium-ion Regulated Exocytosis Neurotransmitter Transport Regulated Exocytosis Spontaneous Neurotransmitter Secretion Regulation Of Calcium Ion-dependent Exocytosis Secretion Regulation Of Regulated Secretory Pathway SNARE Complex Positive Regulation Of Regulated Secretory Pathway Synaptic Vesicle Docking Signal Release Vesicle Docking Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Exocytosis Vesicle-mediated Transport Organelle Localization By Membrane Tethering Positive Regulation Of Exocytosis Positive Regulation Of Vesicle Fusion Membrane Docking Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Vesicle-mediated Transport Presynaptic Active Zone Membrane Regulation Of Secretion By Cell Positive Regulation Of Secretion By Cell Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Secretion Regulation Of Secretion Regulation Of Vesicle Fusion SNAP Receptor Activity Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Membrane Fusion Modulation Of Excitatory Postsynaptic Potential SNARE Binding Presynapse Calcium Ion-regulated Exocytosis Of Neurotransmitter Intracellular Protein Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Establishment Of Localization In Cell Regulation Of Synaptic Vesicle Priming Regulation Of Neurotransmitter Secretion Vesicle Fusion Organelle Membrane Fusion Synaptic Vesicle Membrane Organization	Regulated Exocytosis Exocytosis Regulation Of Secretion By Cell Regulation Of Secretion Regulation Of Transport Calcium-ion Regulated Exocytosis Synapse Regulation Of Exocytosis Positive Regulation Of Regulated Secretory Pathway Secretion By Cell Presynaptic Membrane Positive Regulation Of Exocytosis Secretion Regulation Of Neurotransmitter Secretion Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Vesicle-mediated Transport Synaptic Vesicle Exocytosis Vesicle-mediated Transport Maintenance Of Presynaptic Active Zone Structure Regulation Of Calcium Ion-dependent Exocytosis Presynaptic Active Zone Presynaptic Active Zone Organization Regulation Of Regulated Secretory Pathway Synaptic Vesicle Membrane Synaptic Vesicle Docking Positive Regulation Of Synaptic Transmission Positive Regulation Of Secretion By Cell Modulation Of Chemical Synaptic Transmission Vesicle Docking Myosin V Binding Positive Regulation Of Secretion Positive Regulation Of Calcium Ion-dependent Exocytosis Synaptic Vesicle Priming Syntaxin-1 Binding Positive Regulation Of Neurotransmitter Secretion Organelle Localization By Membrane Tethering Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Membrane Docking Vesicle-mediated Transport In Synapse Exocytic Vesicle Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Neurotransmitter Transport Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Maintenance Of Synapse Structure Establishment Of Vesicle Localization Organelle Localization Protein Transport Clathrin-sculpted Glutamate Transport Vesicle Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Regulation Of Vesicle Fusion
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