TCF25 and LRRK1

Number of citations of the paper that reports this interaction (PubMedID 29513927)
77

Data Source:
BioGRID (pull down)

		TCF25	LRRK1
Description		TCF25 ribosome quality control complex subunit	leucine rich repeat kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol RQC Complex	Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Protein K48-linked Ubiquitination Rescue Of Stalled Ribosome	Positive Regulation Of Signal Transduction Intracellular Signal Transduction Osteoclast Development Bone Resorption Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction
Pathways		Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Brain morphology (MOSTest) ( 32665545) Brown vs. black hair color ( 30531825) Cutaneous squamous cell carcinoma ( 32041948) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Monobrow ( 27182965) Red vs. brown/black hair color ( 30531825) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Rosacea symptom severity ( 29771307) White matter integrity (fractional anisotropy) ( 32358547)	Central corneal thickness ( 28171582 29760442 31798171 32528159) Corneal structure ( 23291589) Height ( 28552196) Systemic lupus erythematosus ( 33272962)
Interacting Genes		13 interacting genes: APPBP2 DERL1 GPRASP2 GPX7 KASH5 LRRK1 MAGEA11 NEK2 PTEN RPS10 SAT1 SHANK3 USP40	53 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CDK1 CDK5RAP2 CHGB CIMIP4 CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TIRAP VGLL4
Entrez ID		22980	79705
HPRD ID		13830	14319
Ensembl ID		ENSG00000141002	ENSG00000154237
Uniprot IDs		Q9BQ70	Q38SD2
PDB IDs			8E04 8E05 8E06 8FAC
Enriched GO Terms of Interacting Partners?		Postsynaptic Density Assembly Postsynaptic Specialization Assembly Spindle Assembly Postsynaptic Density Organization Dendritic Spine Morphogenesis Ubiquitin-specific Protease Binding Postsynaptic Specialization Organization Spindle Organization Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Microtubule Cytoskeleton Organization Neuron Projection Organization Postsynapse Organization Negative Regulation Of Centriole-centriole Cohesion Negative Regulation Of Synaptic Vesicle Clustering Modulation Of Excitatory Postsynaptic Potential Spermidine Binding Social Behavior Membraneless Organelle Assembly Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Spermidine Acetylation Putrescine Catabolic Process Netrin Receptor Binding Derlin-1-VIMP Complex Guanylate Kinase-associated Protein Clustering Meiotic Spindle Pole Catalase Activity Regulation Of Centriole-centriole Cohesion Microtubule Organelle Assembly Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Regulation Of Cell Size Diamine N-acetyltransferase Activity Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Intercellular Bridge Microtubule-based Process Regulation Of Protein Stability Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Synapse Assembly Polyamine Catabolic Process Synaptic Receptor Adaptor Activity Meiotic Cell Cycle Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity	Protein Tyrosine Kinase Activity Protein Kinase Activity Kinase Activity Adenyl-nucleotide Exchange Factor Activity Regulation Of Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Post-translational Protein Modification Negative Regulation Of Apoptotic Process Regulation Of Protein Catabolic Process Regulation Of Protein Ubiquitination Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Catabolic Process Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Nucleotide Binding Protein-folding Chaperone Binding Positive Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Golgi Organization Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Metabolic Process Regulation Of Protein-containing Complex Assembly T Cell Anergy Mitotic Cytokinesis Regulation Of Heart Growth Transferase Activity ATP Binding T Cell Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of JNK Cascade Protein Phosphorylation Positive Regulation Of T Cell Anergy T Cell Tolerance Induction Protein Folding Chaperone Complex Positive Regulation Of Protein Polymerization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Protein Metabolic Process Phosphorylation Cytoskeleton-dependent Cytokinesis Chaperone-mediated Autophagy Regulation Of Organ Growth Regulation Of Signal Transduction Regulation Of T Cell Anergy
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