TCF25 and MAGEA11

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		TCF25	MAGEA11
Name		TCF25 ribosome quality control complex subunit	MAGE family member A11
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol RQC Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body
	Molecular Function	Protein Binding	Protein Binding Histone Deacetylase Binding
	Biological Process	Regulation Of Protein K48-linked Ubiquitination Rescue Of Stalled Ribosome	Negative Regulation Of Transcription By RNA Polymerase II
Pathways		Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	None
GWAS		Blond vs. brown/black hair color ( 30531825 ) Brain morphology (MOSTest) ( 32665545 ) Brown vs. black hair color ( 30531825 ) Cutaneous squamous cell carcinoma ( 32041948 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Monobrow ( 27182965 ) Red vs. brown/black hair color ( 30531825 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Rosacea symptom severity ( 29771307 ) White matter integrity (fractional anisotropy) ( 32358547 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: TUBB3	1 novel interactors: XRN2
Interacting Genes		13 interacting genes: APPBP2 DERL1 GPRASP2 GPX7 KASH5 LRRK1 MAGEA11 NEK2 PTEN RPS10 SAT1 SHANK3 USP40	115 interacting genes: ACMSD ACSM2B ACTN1 AKR1C3 ALDH5A1 AR ARHGAP29 BCL2L11 BEX2 BIRC2 BRD1 C18orf54 C22orf39 CASP7 CAVIN3 CCDC106 CCDC14 CCDC146 CCDC185 CCDC27 CCNA2 CDC20B CDKN2B CEP76 CLUAP1 CORO1A COX7A2L CSNK2A1 CTTNBP2 DLGAP1 DNAJC10 DOCK10 ENOX2 EWSR1 FAM156A FAM161A FBXO46 GADD45GIP1 GCSH GNPDA1 HOXB5 IFI44 IL11 IL6ST ILF3 JADE3 KIAA0408 LMBR1L LNX1 MAPK3 MCRS1 MED28 MGME1 MLF1 MTA1 MXD3 MYOZ1 NCOA2 NDEL1 NDUFAF1 NDUFB9 NIF3L1 NOL4 NOS3 NSUN4 NTAQ1 OTUB2 PCBD2 PCF11 PDE4B PHYH PIK3IP1 PIN4 PLCXD3 PNKD PNKP POLR1D PPIF PPM1K PRDX3 PRKRIP1 PSMF1 RADIL RANBP10 RBM23 REX1BD SH2D4A SNX20 SNX7 SPMIP9 STAR SUCLA2 SUOX SUV39H2 TCEA2 TCEANC TCF25 TEKTL1 THEM5 TMEM123 TPM3 TRIM27 TRIM51 TRMT1 TXN2 UBE2D4 UBE3D USP20 UTP25 VTA1 WTAP ZBTB16 ZCCHC12 ZNF655 ZSWIM2
Entrez ID		22980	4110
HPRD ID		13830	02281
Ensembl ID		ENSG00000141002	ENSG00000185247
Uniprot IDs		Q9BQ70	G5E962 P43364
PDB IDs		Not available	6WJH
GO Terms Enriched among Interactors		Postsynaptic Density Assembly Postsynaptic Specialization Assembly Spindle Assembly Postsynaptic Density Organization Dendritic Spine Morphogenesis Ubiquitin-specific Protease Binding Postsynaptic Specialization Organization Spindle Organization Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Microtubule Cytoskeleton Organization Neuron Projection Organization Postsynapse Organization Negative Regulation Of Centriole-centriole Cohesion Negative Regulation Of Synaptic Vesicle Clustering Modulation Of Excitatory Postsynaptic Potential Spermidine Binding Social Behavior Membraneless Organelle Assembly Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Spermidine Acetylation Putrescine Catabolic Process Netrin Receptor Binding Derlin-1-VIMP Complex Guanylate Kinase-associated Protein Clustering Meiotic Spindle Pole Catalase Activity Regulation Of Centriole-centriole Cohesion Microtubule Organelle Assembly Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Regulation Of Cell Size Diamine N-acetyltransferase Activity Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Intercellular Bridge Microtubule-based Process Regulation Of Protein Stability Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Synapse Assembly Polyamine Catabolic Process Synaptic Receptor Adaptor Activity Meiotic Cell Cycle Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity	Mitochondrial Matrix Protein Binding Mitochondrion Catabolic Process