TCF25 and USP40

Number of citations of the paper that reports this interaction (PubMedID 35605301)
0

Data Source:
BioGRID (two hybrid)

		TCF25	USP40
Description		TCF25 ribosome quality control complex subunit	ubiquitin specific peptidase 40
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol RQC Complex	Nucleus Cytosol
	Molecular Function	Protein Binding	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Regulation Of Protein K48-linked Ubiquitination Rescue Of Stalled Ribosome	Proteolysis Protein Deubiquitination Regulation Of Protein Stability
Pathways		Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Brain morphology (MOSTest) ( 32665545) Brown vs. black hair color ( 30531825) Cutaneous squamous cell carcinoma ( 32041948) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Monobrow ( 27182965) Red vs. brown/black hair color ( 30531825) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Rosacea symptom severity ( 29771307) White matter integrity (fractional anisotropy) ( 32358547)	Bilirubin levels ( 21646302 31319653 31801373 32084209) Crohn's disease ( 22412388) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair greying ( 26926045)
Interacting Genes		13 interacting genes: APPBP2 DERL1 GPRASP2 GPX7 KASH5 LRRK1 MAGEA11 NEK2 PTEN RPS10 SAT1 SHANK3 USP40	45 interacting genes: A2M ACSF2 ADH5 AHSA1 ALDOB APOM C1QA CLN8 COMMD6 DDB1 DDB2 EEF1A1 EEF1D EPB41L1 HCG11 HEBP2 HINT1 HSPA8 IL11RA ITGA6 LDHB LRP2 MT2A MTRNR2L1 NORAD OCLN OS9 PMS2P1 PSTK RACK1 RNF7 RPL30 RPS18 RPS20 RPS3A SLC12A1 SLC2A5 SRSF2 STT3A TCF25 TOMM20 TPT1 TRAPPC8 UBC VAPA
Entrez ID		22980	55230
HPRD ID		13830	07166
Ensembl ID		ENSG00000141002	ENSG00000085982
Uniprot IDs		Q9BQ70	A0A7I2YQ75 C9JK14 Q9NVE5
PDB IDs
Enriched GO Terms of Interacting Partners?		Postsynaptic Density Assembly Postsynaptic Specialization Assembly Spindle Assembly Postsynaptic Density Organization Dendritic Spine Morphogenesis Ubiquitin-specific Protease Binding Postsynaptic Specialization Organization Spindle Organization Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Microtubule Cytoskeleton Organization Neuron Projection Organization Postsynapse Organization Negative Regulation Of Centriole-centriole Cohesion Negative Regulation Of Synaptic Vesicle Clustering Modulation Of Excitatory Postsynaptic Potential Spermidine Binding Social Behavior Membraneless Organelle Assembly Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Spermidine Acetylation Putrescine Catabolic Process Netrin Receptor Binding Derlin-1-VIMP Complex Guanylate Kinase-associated Protein Clustering Meiotic Spindle Pole Catalase Activity Regulation Of Centriole-centriole Cohesion Microtubule Organelle Assembly Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Regulation Of Cell Size Diamine N-acetyltransferase Activity Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Intercellular Bridge Microtubule-based Process Regulation Of Protein Stability Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Synapse Assembly Polyamine Catabolic Process Synaptic Receptor Adaptor Activity Meiotic Cell Cycle Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity	Extracellular Exosome Translation Cytosolic Small Ribosomal Subunit Cytosolic Ribosome Ribosome Cytoplasmic Translation Translational Elongation Eukaryotic Translation Elongation Factor 1 Complex Small Ribosomal Subunit Cul4B-RING E3 Ubiquitin Ligase Complex Fructose Binding Cadherin Binding Protein Metabolic Process Host-mediated Activation Of Viral Genome Replication UV-damage Excision Repair Host-mediated Perturbation Of Viral Genome Replication Ribonucleoprotein Complex Insulin-like Growth Factor I Binding Response To Redox State Cul4A-RING E3 Ubiquitin Ligase Complex Import Across Plasma Membrane Structural Constituent Of Ribosome
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