TCF25 and GPX7

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TCF25	GPX7
Name		TCF25 ribosome quality control complex subunit	glutathione peroxidase 7
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol RQC Complex	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Protein Binding	Catalase Activity Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Oxidoreductase Activity
	Biological Process	Regulation Of Protein K48-linked Ubiquitination Rescue Of Stalled Ribosome	Response To Oxidative Stress Cellular Response To Oxidative Stress Cellular Oxidant Detoxification
Pathways		Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Detoxification of Reactive Oxygen Species
Drugs		None	Glutathione Glutathione Glutathione disulfide Benzoyl peroxide
GWAS		Blond vs. brown/black hair color ( 30531825 ) Brain morphology (MOSTest) ( 32665545 ) Brown vs. black hair color ( 30531825 ) Cutaneous squamous cell carcinoma ( 32041948 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Monobrow ( 27182965 ) Red vs. brown/black hair color ( 30531825 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Rosacea symptom severity ( 29771307 ) White matter integrity (fractional anisotropy) ( 32358547 )	Joint mobility (Beighton score) ( 27182965 )
Interacting Genes		13 interacting genes: APPBP2 DERL1 GPRASP2 GPX7 KASH5 LRRK1 MAGEA11 NEK2 PTEN RPS10 SAT1 SHANK3 USP40	13 interacting genes: ASPH CEP70 CPEB2 CPNE7 ERO1A GET3 NCALD NTAQ1 SGTA SGTB TCF25 UBQLN2 UBQLN4
Entrez ID		22980	2882
HPRD ID		13830	13606
Ensembl ID		ENSG00000141002	ENSG00000116157
Uniprot IDs		Q9BQ70	Q96SL4
PDB IDs		Not available	2P31
GO Terms Enriched among Interactors		Postsynaptic Density Assembly Postsynaptic Specialization Assembly Spindle Assembly Postsynaptic Density Organization Dendritic Spine Morphogenesis Ubiquitin-specific Protease Binding Postsynaptic Specialization Organization Spindle Organization Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Microtubule Cytoskeleton Organization Neuron Projection Organization Postsynapse Organization Negative Regulation Of Centriole-centriole Cohesion Negative Regulation Of Synaptic Vesicle Clustering Modulation Of Excitatory Postsynaptic Potential Spermidine Binding Social Behavior Membraneless Organelle Assembly Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Spermidine Acetylation Putrescine Catabolic Process Netrin Receptor Binding Derlin-1-VIMP Complex Guanylate Kinase-associated Protein Clustering Meiotic Spindle Pole Catalase Activity Regulation Of Centriole-centriole Cohesion Microtubule Organelle Assembly Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Regulation Of Cell Size Diamine N-acetyltransferase Activity Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Intercellular Bridge Microtubule-based Process Regulation Of Protein Stability Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Synapse Assembly Polyamine Catabolic Process Synaptic Receptor Adaptor Activity Meiotic Cell Cycle Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity	TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of ERAD Pathway Regulation Of Proteolysis Regulation Of ERAD Pathway Protein Insertion Into ER Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Establishment Of Protein Localization To Membrane Positive Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Response To Endoplasmic Reticulum Stress Protein-N-terminal Glutamine Amidohydrolase Activity Negative Regulation Of Cytoplasmic Translational Elongation Protein Insertion Into Membrane Peptidyl-aspartic Acid 3-dioxygenase Activity Cellular Response To Calcium Ion Protein Targeting To Membrane Negative Regulation Of G Protein-coupled Receptor Internalization Protein-N-terminal Asparagine Amidohydrolase Activity Nuclear Proteasome Complex Autophagosome GET Complex Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway RQC Complex Negative Regulation Of Autophagosome Maturation Regulation Of Protein Catabolic Process BAT3 Complex Binding Negative Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Proteasomal Protein Catabolic Process Activation Of Store-operated Calcium Channel Activity Cytosolic Proteasome Complex Negative Regulation Of Translational Elongation Positive Regulation Of Store-operated Calcium Channel Activity Regulation Of Sequestering Of Calcium Ion Response To Calcium Ion Regulation Of Protein-containing Complex Disassembly Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein K48-linked Ubiquitination Cellular Response To Hypoxia Thiol Oxidase Activity Negative Regulation Of ERAD Pathway Cellular Response To Decreased Oxygen Levels