SCMH1 and GMNN

Number of citations of the paper that reports this interaction (PubMedID 14973489)
0

Data Source:
HPRD (in vitro)

		SCMH1	GMNN
Description		Scm polycomb group protein homolog 1	geminin DNA replication inhibitor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Transcription Repressor Complex
	Molecular Function	Chromatin Binding Protein Binding Histone Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of DNA-templated Transcription Heterochromatin Formation Negative Regulation Of DNA-templated Transcription	Regulation Of DNA Replication Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Animal Organ Morphogenesis Regulation Of DNA-templated DNA Replication Initiation Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Protein-containing Complex Assembly DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-templated DNA Replication
Pathways			Assembly of the pre-replicative complex Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs		Mercaptoethanol
Diseases
GWAS		Adventurousness ( 30643258) Appendicular lean mass ( 33097823) Atrial fibrillation ( 29892015 30061737) General risk tolerance (MTAG) ( 30643258) Height ( 18391952 20881960 23563607 25282103) Hip circumference adjusted for BMI ( 34021172) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Rapid response to perioperative phenylephrine (change in mean arterial pressure) ( 33168928)	Metabolite levels ( 23823483)
Interacting Genes		23 interacting genes: EWSR1 FXR1 FXR2 GMNN HK1 HPCAL4 LYPLA2 LZTR1 MAGEA12 MAML3 MOB4 PCBD1 PHC1 PHC2 POLR2M RNF2 SFMBT1 SFMBT2 TMEM11 TOB1 TSC1 UBQLN1 UBQLN4	34 interacting genes: ARNT AURKA CASP3 CDC20 CDKN1A CDKN2A CDT1 CEBPA CSNK2A1 FZR1 GLIS2 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KANK2 KAT7 LNX1 MCM6 NCF1 PHC1 PTPN11 REPIN1 RNF2 SAPCD2 SCMH1 SIX3 SMARCA4 ZNF250 ZNF439
Entrez ID		22955	51053
HPRD ID		11540	06783
Ensembl ID		ENSG00000010803	ENSG00000112312
Uniprot IDs		A0A8Q3SHN2 A0A8Q3SHR9 B3KMZ7 B4DWE6 Q96GD3	O75496
PDB IDs		2P0K	1T6F 1UII 2LP0 2WVR 4BRY 7KLZ
Enriched GO Terms of Interacting Partners?		PcG Protein Complex PRC1 Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sex Chromatin Chromatin Binding Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Metabolic Process Histone Binding Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Transcription Corepressor Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Translation Regulator Activity Negative Regulation Of Biosynthetic Process Nucleus Positive Regulation Of MRNA Catabolic Process Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Gene Expression Positive Regulation Of MRNA Metabolic Process Aggresome Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Glucosamine Kinase Activity Memory T Cell Differentiation Negative Regulation Of Macroautophagy Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Store-operated Calcium Channel Activity Polyubiquitin Modification-dependent Protein Binding Maintenance Of ER Location Negative Regulation Of Catabolic Process Nucleoplasm Heterochromatin 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Perinuclear Region Of Cytoplasm Regulation Of Macroautophagy Regulation Of MRNA Stability Regulation Of RNA Stability	Negative Regulation Of Cell Cycle Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Cell Cycle DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Anterior/posterior Pattern Specification Nucleus Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regionalization DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Skeletal System Morphogenesis Regulation Of Cell Cycle Process Proximal/distal Pattern Formation Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Embryonic Skeletal System Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Embryonic Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Chromatin Binding Regulation Of DNA-templated DNA Replication Initiation Regulation Of Mitotic Cell Cycle Phase Transition Chromatin Embryonic Organ Morphogenesis Regulation Of Mitotic Cell Cycle Nuclear Body Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Process Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process
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