GMNN and HOXD10

Number of citations of the paper that reports this interaction (PMID 14973489)
53

Data Source:
HPRD (in vitro)

		GMNN	HOXD10
Gene Name		geminin, DNA replication inhibitor	homeobox D10
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus
	Molecular Function	Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding Repressing Transcription Factor Binding	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding
	Biological Process	Mitotic Cell Cycle Protein Complex Assembly Negative Regulation Of DNA Replication Organ Morphogenesis Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated	Transcription, DNA-templated Single Fertilization Skeletal Muscle Tissue Development Adult Locomotory Behavior Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Spinal Cord Motor Neuron Cell Fate Specification Embryonic Limb Morphogenesis Forelimb Morphogenesis Hindlimb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Skeletal System Morphogenesis Peripheral Nervous System Neuron Development Neuromuscular Process
Pathways		DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Removal of licensing factors from origins CDT1 association with the CDC6:ORC:origin complex Association of licensing factors with the pre-replicative complex Cell Cycle, Mitotic Assembly of the pre-replicative complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: ARNT AURKA CASP3 CCDC146 CDKN1A CDKN2A CDT1 CSNK2A1 HDAC1 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KAT7 MCM6 NCF1 PHC1 REPIN1 SCMH1 SIX3 SMARCA4 ZNF439	5 interactors: CREBBP EP300 GMNN HMGB1 PBX1
Entrez ID		51053	3236
HPRD ID		06783	00867
Ensembl ID		ENSG00000112312	ENSG00000128710
Uniprot IDs		O75496	P28358
PDB IDs		1T6F 1UII 2LP0 2WVR 4BRY
Enriched GO Terms of Interacting Partners?		Anterior/posterior Pattern Specification Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Macromolecule Biosynthetic Process Pattern Specification Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Embryonic Morphogenesis Anatomical Structure Morphogenesis Gene Expression Embryonic Organ Development Embryonic Organ Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Embryo Development Proximal/distal Pattern Formation Embryonic Skeletal System Morphogenesis Regulation Of Cell Cycle Multicellular Organismal Development Negative Regulation Of Cell Cycle Developmental Process Skeletal System Morphogenesis Organ Morphogenesis Regulation Of Cell Cycle Process Embryonic Limb Morphogenesis Embryonic Skeletal System Development Regulation Of Metabolic Process Limb Morphogenesis Skeletal System Development Metabolic Process Chromatin Modification Limb Development Organ Development System Development Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Phase Transition Positive Regulation Of Transcription, DNA-templated	N-terminal Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia N-terminal Protein Amino Acid Modification Regulation Of Cellular Response To Heat Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Negative Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To Heat Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Type I Interferon Production Chromatin Modification Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Type I Interferon Production Regulation Of Transcription, DNA-templated Histone H2B Acetylation Negative Regulation Of Apoptotic Cell Clearance Regulation Of Nucleic Acid-templated Transcription Cellular Response To Oxygen Levels Regulation Of RNA Biosynthetic Process Response To Heat Histone Acetylation Regulation Of RNA Metabolic Process Internal Peptidyl-lysine Acetylation Positive Regulation Of Binding Peptidyl-lysine Acetylation Chromatin Organization Internal Protein Amino Acid Acetylation Negative Regulation Of Cellular Metabolic Process Protein Acetylation Immune System Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Notch Signaling Pathway Innate Immune Response Regulation Of Gene Expression Anatomical Structure Development Stem Cell Maintenance Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Regulation Of Nitrogen Compound Metabolic Process
Tagcloud ?			10b 4t1 antagomir delivered delivering efficaciously endosome escape get h6l9 hinder histidines impede lip liposomal liposomes lysosome lysosomes lytic meantime micrornas mimicking paclitaxel ph5 prominently protonated ptx reach stunt
Tagcloud (Difference) ?			10b 4t1 antagomir delivered delivering efficaciously endosome escape get h6l9 hinder histidines impede lip liposomal liposomes lysosome lysosomes lytic meantime micrornas mimicking paclitaxel ph5 prominently protonated ptx reach stunt
Tagcloud (Intersection) ?